Design, synthesis and evaluation of novel cinnamic acid derivatives bearing N-benzyl pyridinium moiety as multifunctional cholinesterase inhibitors for Alzheimer’s disease

Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

(2017) Ashley I. Bush   JOURNAL OF ALZHEIMERS DISEASE

Design, synthesis and biological evaluation of novel donepezil–coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease

(2016) Sai-Sai Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ferulic acid–carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents

(2016) Lei Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

(2016) Wanli Pan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New cinnamic – N -benzylpiperidine and cinnamic – N , N -dibenzyl( N -methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

(2016) Martín Estrada et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease

(2016) Wei Xu et al.   MedChemComm

Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors

(2015) Chaolei Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel marine-derived indole-based 1,2,4-oxadiazoles derivatives as multifunctional neuroprotective agents

(2015) Cheng-Shi Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protective effects of ferulic acid and related polyphenols against glyoxal- or methylglyoxal-induced cytotoxicity and oxidative stress in isolated rat hepatocytes

(2015) Abdullah Al Maruf et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Multifunctional tacrine–trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties

(2015) Sai-Sai Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors

(2015) Farzaneh Baharloo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure-activity relationship study of benzofuran-based chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitors

(2015) Manizheh Mostofi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Curcumin Analogs as Inhibitors of β -Amyloid Peptide Aggregation: Potential Therapeutic and Diagnostic Agents for Alzheimer's Disease

(2015) Syed Abbas Bukhari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants

(2015) Antonella Sgarbossa et al.   Nutrients

Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer’s disease

(2014) Jin-Shuai Lan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Tacrine-Grafted Ugi Adducts as Multipotent Anti-Alzheimer Drugs: A Synthetic Renewal in Tacrine-Ferulic Acid Hybrids

(2014) Mohamed Benchekroun et al.   ChemMedChem

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

(2014) Angel Agis-Torres et al.   Current Neuropharmacology

Preparation, In Vitro Screening and Molecular Modelling of Monoquaternary Compounds Related to the Selective Acetylcholinesterase Inhibitor BW284c51

(2014) Ondrej Benek et al.   Medicinal Chemistry

Alzheimer's disease and epigenetic diet

(2014) Zeynep Sezgin et al.   NEUROCHEMISTRY INTERNATIONAL

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Curcumin as a Potential Treatment for Alzheimer's Disease: A Study of the Effects of Curcumin on Hippocampal Expression of Glial Fibrillary Acidic Protein

(2013) Yunliang Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Multi-Target Compounds Acting in the Central Nervous System Designed From Natural Products

(2013) X. Chen et al.   CURRENT MEDICINAL CHEMISTRY

Memantine in Patients with Moderate to Severe Alzheimer's Disease: Meta-Analyses Using Realistic Definitions of Response

(2013) David Wilkinson et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Design, synthesis and evaluation of novel tacrine–coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease

(2013) Sai-Sai Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

(2013) Chuanjun Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel tacrine–rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease

(2013) Su-Yi Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

(2012) Huang Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, molecular modeling and evaluation of novel N′-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aβ aggregation

(2012) Eda Özturan Özer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties

(2012) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-Target-Directed Ligands in Alzheimer's Disease Treatment

(2011) M. Bajda et al.   CURRENT MEDICINAL CHEMISTRY

Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

(2011) Carles Galdeano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

REVIEW: Curcumin and Alzheimer's Disease

(2010) Tsuyoshi Hamaguchi et al.   CNS Neuroscience & Therapeutics

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

(2010) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Beneficial Catalytic Immunity to Aβ Peptide

(2010) Sudhir Paul et al.   REJUVENATION RESEARCH

Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation

(2009) Brian C. Magliaro et al.   BRAIN RESEARCH

Ferulic acid and its therapeutic potential as a hormetin for age-related diseases

(2008) Eugenio Barone et al.   BIOGERONTOLOGY

Acetylcholinesterase Inhibitors as Disease-Modifying Therapies for Alzheimers Disease

(2008) D. Munoz-Torrero   CURRENT MEDICINAL CHEMISTRY

Bis-(−)-nor-meptazinols as Novel Nanomolar Cholinesterase Inhibitors with High Inhibitory Potency on Amyloid-β Aggregation

(2008) Qiong Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY