Solute carriers as potential oncodrivers or suppressors: their key functions in malignant tumor formation

Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells

(2020) Alagesan Seetha et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Quercetin overcomes colon cancer cells resistance to chemotherapy by inhibiting solute carrier family 1, member 5 transporter

(2020) Yuanyuan Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

JPH203, a newly developed anti-cancer drug, shows a preincubation inhibitory effect on L-type amino acid transporter 1 function

(2020) Kentaro Okunushi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme

(2020) Azizah M. Malebari et al.   Pharmaceuticals

Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells

(2019) Xiaowen Guan et al.   AAPS Journal

MiR-223-3p promotes cell proliferation and metastasis by downregulating SLC4A4 in clear cell renal cell carcinoma

(2019) Wen Xiao et al.   Aging-US

Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis

(2019) G. Comito et al.   ONCOGENE

Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling

(2019) Kexin Sun et al.   EBioMedicine

γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity

(2019) Alessandro Corti et al.   Scientific Reports

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

(2019) Cristina Toffalori et al.   NATURE MEDICINE

Targeting the hepcidin-ferroportin pathway in anaemia of chronic kidney disease

(2019) Matthew Sheetz et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

SLC5A1 promotes growth and proliferation of pancreatic carcinoma via glucose-dependent AMPK/mTOR signaling

(2019) Hui-Feng Gao et al.   Cancer Management and Research

Sotagliflozin: First Global Approval

(2019) Anthony Markham et al.   DRUGS

Analysis of miRNA–mRNA network reveals miR-140-5p as a suppressor of breast cancer glycolysis via targeting GLUT1

(2019) Yunjie He et al.   Epigenomics

Furosemide use and survival in patients with esophageal or gastric cancer: a population-based cohort study

(2019) Peipei Liu et al.   BMC CANCER

Reserpine induces apoptosis and cell cycle arrest in hormone independent prostate cancer cells through mitochondrial membrane potential failure

(2018) Manjula Devi Ramamoorthy et al.   Anti-Cancer Agents in Medicinal Chemistry

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

(2018) Xianmin Mu et al.   CELL CYCLE

MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer

(2018) Ying Zhang et al.   Molecular Cancer

Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression

(2018) Furong Wang et al.   Oncogenesis

Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6)

(2018) Emre Karakus et al.   Frontiers in Pharmacology

Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer

(2018) Sara Bisetto et al.   Frontiers in Oncology

Anti‐tumor effects of antibodies to L‐type amino‐acid transporter 1 ( LAT 1) bound to human and monkey LAT 1 with dual avidity modes

(2018) Shiho Ueda et al.   CANCER SCIENCE

Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas

(2018) Xiudong Guan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro

(2018) Tao Jiang et al.   OncoTargets and Therapy

Tumor Microenvironment-Induced Immunometabolic Reprogramming of Natural Killer Cells

(2018) Andrea M. Chambers et al.   Frontiers in Immunology

Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876

(2018) Yibao Ma et al.   Cancers

Activation of Nuclear Factor−κB by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter SLC26A3

(2017) Anoop Kumar et al.   GASTROENTEROLOGY

Solute Carrier Family 39 Member 6 Gene Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-Kinase Signaling, and Up-regulating Genes That Regulate Metastasis

(2017) Xinxin Cheng et al.   GASTROENTEROLOGY

Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake

(2017) Kosuke Kaji et al.   INTERNATIONAL JOURNAL OF CANCER

Flipping a citrate switch on liver cancer cells

(2017) Jeffrey M. Peters   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells

(2017) Zhihui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genotypes of SLC22A4 and SLC22A5 regulatory loci are predictive of the response of chronic myeloid leukemia patients to imatinib treatment

(2017) Monika Jaruskova et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway

(2017) Jia-Xing Zhang et al.   Molecular Cancer

Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study

(2017) Jing Zhao et al.   MOLECULAR CARCINOGENESIS

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

(2017) J Feng et al.   ONCOGENE

A Novel Homozygous SLC2A9 Mutation Associated with Renal-Induced Hypouricemia

(2016) Martin Windpessl et al.   AMERICAN JOURNAL OF NEPHROLOGY

KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells

(2016) Schammim Ray Amith et al.   BIOCHEMICAL PHARMACOLOGY

Metabolic scavenging by cancer cells: when the going gets tough, the tough keep eating

(2016) Evdokia Michalopoulou et al.   BRITISH JOURNAL OF CANCER

Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential

(2016) Wen-Lian Chen et al.   CANCER CELL

Probenecid Sensitizes Neuroblastoma Cancer Stem Cells to Cisplatin

(2016) Denise Campos-Arroyo et al.   CANCER INVESTIGATION

Glutamate release inhibitor, Riluzole, inhibited proliferation of human hepatocellular carcinoma cells by elevated ROS production

(2016) Hyang Sook Seol et al.   CANCER LETTERS

The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4

(2016) Céline Pinheiro et al.   CELL CYCLE

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer

(2016) Heidi Griesmann et al.   GUT

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of monocarboxylate transporter 1 suppresses the proliferation of glioblastoma stem cells

(2016) Tetsuya Takada et al.   Journal of Physiological Sciences

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Knockdown of SLC34A2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Invasion

(2016) Yanhua Li et al.   ONCOLOGY RESEARCH

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

(2016) Q Qu et al.   Cell Death & Disease

Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation

(2016) Jianmin Wang et al.   Oncotarget

Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2

(2016) Emily Yun-Chia Chang et al.   PLoS One

Low pH increases the yield of exosome isolation

(2015) Jae-Jun Ban et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions

(2015) Ashish Gurav et al.   BIOCHEMICAL JOURNAL

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

(2015) Ming-zhe Ma et al.   CANCER LETTERS

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

Increased expression ofSolute carrier family 12 member 5via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer

(2015) Lixia Xu et al.   GUT

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

(2015) Yun-Yong Park et al.   HEPATOLOGY

Deregulated SLC2A1 Promotes Tumor Cell Proliferation and Metastasis in Gastric Cancer

(2015) Shiyan Yan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Down-Regulation of SLC8A1 as a Putative Apoptosis Evasion Mechanism by Modulation of Calcium Levels in Penile Carcinoma

(2015) Juan J. Muñoz et al.   JOURNAL OF UROLOGY

Anti-angiogenic Effects of Bumetanide Revealed by DCE-MRI with a Biodegradable Macromolecular Contrast Agent in a Colon Cancer Model

(2015) Anthony S. Malamas et al.   PHARMACEUTICAL RESEARCH

miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma

(2015) Junwei Lian et al.   Oncotarget

Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARγ/OCTN2 pathway

(2014) Qiang Qu et al.   ANTI-CANCER DRUGS

Feeding the Critically Ill Patient

(2014) Stephen A. McClave et al.   CRITICAL CARE MEDICINE

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resveratrol and its major sulfated conjugates are substrates of organic anion transporting polypeptides (OATPs): Impact on growth of ZR-75-1 breast cancer cells

(2014) Juliane Riha et al.   MOLECULAR NUTRITION & FOOD RESEARCH

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

Reduced Organic Anion Transporter Expression Is a Risk Factor for Hepatocellular Carcinoma in Chronic Hepatitis C Patients: A Propensity Score Matching Study

(2014) Yutaka Yasui et al.   ONCOLOGY

Role of the Na+/K+/2Cl-cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma

(2014) Atsushi Shiozaki   WORLD JOURNAL OF GASTROENTEROLOGY

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

The association between the expression of solute carrier transporters and the prognosis of pancreatic cancer

(2013) Beatrice Mohelnikova-Duchonova et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells

(2013) I. B. Barsoum et al.   CANCER RESEARCH

Cancer metabolism, stemness and tumor recurrence

(2013) Joseph M. Curry et al.   CELL CYCLE

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma

(2013) Rita Sattler et al.   JOURNAL OF NEUROSURGERY

The SLC22 family with transporters of organic cations, anions and zwitterions

(2013) Hermann Koepsell   MOLECULAR ASPECTS OF MEDICINE

TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells

(2013) Daniel S Straus   Molecular Cancer

Glucose transporter-1 expression in CD133+ laryngeal carcinoma Hep-2 cells

(2013) XIAO-HONG CHEN et al.   Molecular Medicine Reports

EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors

(2013) Jiangong Ren et al.   PROSTATE

Effect on the Expression of MMP-2, MT-MMP in Laryngeal Carcinoma Hep-2 Cell Line by Antisense Glucose Transporter-1

(2012) Ying-Ying Xu et al.   ARCHIVES OF MEDICAL RESEARCH

Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions

(2012) Hiroshi Arakawa et al.   BIOCHEMICAL PHARMACOLOGY

Caveolin-1 Increases Aerobic Glycolysis in Colorectal Cancers by Stimulating HMGA1-MediatedGLUT3Transcription

(2012) Tae-Kyu Ha et al.   CANCER RESEARCH

SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival

(2012) M. Hassanein et al.   CLINICAL CANCER RESEARCH

Impact of Tumor Microenvironment and Epithelial Phenotypes on Metabolism in Breast Cancer

(2012) H. A. Brauer et al.   CLINICAL CANCER RESEARCH

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Antiproliferative Effects of Fluoxetine on Colon Cancer Cells and in a Colonic Carcinogen Mouse Model

(2012) Vinicius Kannen et al.   PLoS One

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

H+-myo-Inositol Transporter SLC2A13 as a Potential Marker for Cancer Stem Cells in an Oral Squamous Cell Carcinoma

(2011) D. G. Lee et al.   CURRENT CANCER DRUG TARGETS

Ca2+Influx through Reverse Mode Na+/Ca2+Exchange Is Critical for Vascular Endothelial Growth Factor-mediated Extracellular Signal-regulated Kinase (ERK) 1/2 Activation and Angiogenic Functions of Human Endothelial Cells

(2011) Petros Andrikopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate

(2011) E Babu et al.   ONCOGENE

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

(2011) D. A. Chan et al.   Science Translational Medicine

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

(2010) Giuliano Ciarimboli et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of PTEN Binding Adapter Protein NHERF1 from Plasma Membrane in Glioblastoma Contributes to PTEN Inactivation

(2010) J. R. Molina et al.   CANCER RESEARCH

Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells

(2010) Monzavi-Karbassi   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of a Novel Transport-independent Function of PiT1/SLC20A1 in the Regulation of TNF-induced Apoptosis

(2010) Christine Salaün et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

(2010) D S Wheeler et al.   ONCOGENE

Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers

(2009) S Irshad et al.   CELL DEATH AND DIFFERENTIATION

cGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment

(2009) Darren D Browning et al.   Future Medicinal Chemistry

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

(2009) E. Delpire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Promoter Hypermethylation Mediates Downregulation of Thiamine Receptor SLC19A3 in Gastric Cancer

(2009) Xin Liu et al.   TUMOR BIOLOGY

Life-threatening toxicities in a patient with UGT1A1*6/*28 and SLCO1B1*15/*15 genotypes after irinotecan-based chemotherapy

(2008) Hiroshi Takane et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Regulation of Prostaglandin Transporters in Colorectal Neoplasia

(2008) V. R. Holla et al.   Cancer Prevention Research

Significance of Organic Cation Transporter 3 (SLC22A3) Expression for the Cytotoxic Effect of Oxaliplatin in Colorectal Cancer

(2008) S. Yokoo et al.   DRUG METABOLISM AND DISPOSITION

Organic Anion Transporter 2 (SLC22A7) Is a Facilitative Transporter of cGMP

(2008) C. D. Cropp et al.   MOLECULAR PHARMACOLOGY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of iron metabolism-related genes in diethylnitrosamine-induced mouse liver tumors

(2008) Pilju Youn et al.   TOXICOLOGY LETTERS