Targeting the hepcidin-ferroportin pathway in anaemia of chronic kidney disease

Current and future chemical therapies for treating anaemia in chronic kidney disease

(2017) Francesco Locatelli et al.   EXPERT OPINION ON PHARMACOTHERAPY

A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia

(2017) Saroj Vadhan-Raj et al.   Journal of Hematology & Oncology

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving Maintenance Hemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study

(2016) Robert Provenzano et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

The Labile Side of Iron Supplementation in CKD

(2015) I. Slotki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hepcidin-25 in Diabetic Chronic Kidney Disease Is Predictive for Mortality and Progression to End Stage Renal Disease

(2015) Martin Wagner et al.   PLoS One

Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats

(2014) M. Theurl et al.   HAEMATOLOGICA

Considerations and Challenges in Defining Optimal Iron Utilization in Hemodialysis

(2014) D. M. Charytan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Association between hemoglobin variability, serum ferritin levels, and adverse events/mortality in maintenance hemodialysis patients

(2014) Takahiro Kuragano et al.   KIDNEY INTERNATIONAL

A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis

(2014) Guillem Casanovas et al.   PLoS Computational Biology

Meta-analysis: Erythropoiesis-Stimulating Agents in Patients With Chronic Kidney Disease

(2013) Suetonia C. Palmer   ANNALS OF INTERNAL MEDICINE

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression

(2012) David M. Frazer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hepcidin-25 is related to cardiovascular events in chronic haemodialysis patients

(2012) Neelke C. van der Weerd et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation

(2011) Chia Chi Sun et al.   AMERICAN JOURNAL OF HEMATOLOGY

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo

(2011) I. Theurl et al.   HAEMATOLOGICA

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacokinetics of Anti-hepcidin Monoclonal Antibody Ab 12B9m and Hepcidin in Cynomolgus Monkeys

(2010) Jim J. Xiao et al.   AAPS Journal

Iron-Sensing Proteins that Regulate Hepcidin and Enteric Iron Absorption

(2010) Mitchell D. Knutson   Annual Review of Nutrition

Serum ferritin predicts prognosis in hemodialysis patients: the Nishinomiya study

(2010) Yukiko Hasuike et al.   Clinical and Experimental Nephrology

A Dual-Monoclonal Sandwich ELISA Specific for Hepcidin-25

(2010) A. M. Butterfield et al.   CLINICAL CHEMISTRY

Hepcidin targets ferroportin for degradation in hepatocytes

(2009) G. Ramey et al.   HAEMATOLOGICA

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

(2009) Guillem Casanovas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease

(2009) Daniela V. Barreto et al.   KIDNEY INTERNATIONAL

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease

(2009) Marc A. Pfeffer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Iron metabolism in the anemia of chronic disease

(2008) Günter Weiss   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Approximations of the target-mediated drug disposition model and identifiability of model parameters

(2008) Leonid Gibiansky et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS