Deciphering the roles of the constitutive androstane receptor in energy metabolism

Coordinated Regulation of Nuclear Receptor CAR by CCRP/DNAJC7, HSP70 and the Ubiquitin-Proteasome System

(2014) Yoav E. Timsit et al.   PLoS One

Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5

(2014) Takashi Ashino et al.   Redox Biology

Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4α/CAR/RXR/PSF complex

(2013) Hui Peng et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation

(2013) Julia Lemmen et al.   BRAIN RESEARCH

In Vivo Deletion of CAR Resulted in High Bone Mass Phenotypes in Male Mice

(2013) Hwa Young Cho et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting Hepatocyte Nuclear Factor 4 

(2013) X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells

(2013) A A Takwi et al.   ONCOGENE

Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

(2013) S. Mutoh et al.   Science Signaling

Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression

(2013) Ryota Shizu et al.   TOXICOLOGY LETTERS

Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice

(2012) Hisashi Masuyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages

(2012) Leyuan Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nuclear Receptors Reverse McGarry's Vicious Cycle to Insulin Resistance

(2012) David D. Moore   Cell Metabolism

Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

(2012) Wei-Dong Chen et al.   HEPATOLOGY

Demethoxycurcumin Modulates Prostate Cancer Cell Proliferation via AMPK-Induced Down-regulation of HSP70 and EGFR

(2012) Chao-Ming Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor

(2012) Ryota Shizu et al.   PLoS One

Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR

(2012) Hiroki Tojima et al.   TOXICOLOGY LETTERS

Constitutive Androstane Receptor Activation Decreases Plasma Apolipoprotein B–Containing Lipoproteins and Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

(2011) Anne-Laure Sberna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter

(2011) Barbara Renga et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

(2011) Makoto Osabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism

(2011) Tenghui Chen et al.   JOURNAL OF HEPATOLOGY

Functional crosstalk of CAR–LXR and ROR–LXR in drug metabolism and lipid metabolism

(2010) Lei Xiao et al.   ADVANCED DRUG DELIVERY REVIEWS

Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells

(2010) Qianming Bai et al.   ATHEROSCLEROSIS

Constitutive androstane/active receptor is a target of retinoic acid receptor in humans

(2010) Kosuke Saito et al.   BIOCHEMICAL PHARMACOLOGY

Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor

(2010) D. Takizawa et al.   DRUG METABOLISM AND DISPOSITION

CCAAT/Enhancer-binding Protein α (C/EBPα) and Hepatocyte Nuclear Factor 4α (HNF4α) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene

(2010) Marta Benet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice

(2010) Anne Laure Sberna et al.   JOURNAL OF HEPATOLOGY

Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25-Hydroxycholesterol and 25-Hydroxycholesterol-3-sulfate

(2010) Leyuan Xu et al.   LIPIDS

Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

A Functional Cross-Talk between Liver X Receptor-  and Constitutive Androstane Receptor Links Lipogenesis and Xenobiotic Responses

(2010) Y. Zhai et al.   MOLECULAR PHARMACOLOGY

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

(2009) Tadeja Režen et al.   BMC GENOMICS

Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation

(2009) K.-y. Kim et al.   CANCER RESEARCH

Thyroid Hormone Is Necessary for Expression of Constitutive Androstane Receptor in Rat Hepatocytes

(2009) H. Ooe et al.   DRUG METABOLISM AND DISPOSITION

Early growth response 1 loops theCYP2B6promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4α

(2009) Kaoru Inoue et al.   FEBS LETTERS

Association of a single nucleotide polymorphism in the constitutive androstane receptor gene with bone mineral density

(2009) Tomohiko Urano et al.   Geriatrics & Gerontology International

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

(2009) Jie Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dependence on the Microtubule Network and 90-kDa Heat Shock Protein of Phenobarbital-Induced Nuclear Translocation of the Rat Constitutive Androstane Receptor

(2009) Y. Kanno et al.   MOLECULAR PHARMACOLOGY

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

(2009) B. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway

(2008) Yongjie Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Meter of Metabolism

(2008) Carla B. Green et al.   CELL

The Antiapoptotic Factor Growth Arrest and DNA-Damage-Inducible 45   Regulates the Nuclear Receptor Constitutive Active/Androstane Receptor-Mediated Transcription

(2008) Y. Yamamoto et al.   DRUG METABOLISM AND DISPOSITION

ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses

(2008) M. Pascual et al.   DRUG METABOLISM AND DISPOSITION

Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver

(2008) Y.-K. J. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice

(2008) David Masson et al.   JOURNAL OF LIPID RESEARCH

Nuclear Receptor Coactivator 6 Mediates the Synergistic Activation of Human Cytochrome P-450 2C9 by the Constitutive Androstane Receptor and Hepatic Nuclear Factor-4 

(2008) S. Surapureddi et al.   MOLECULAR PHARMACOLOGY

Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression

(2008) A. Roth et al.   MOLECULAR PHARMACOLOGY

PPP1R16A, The Membrane Subunit of Protein Phosphatase 1 , Signals Nuclear Translocation of the Nuclear Receptor Constitutive Active/Androstane Receptor

(2008) T. Sueyoshi et al.   MOLECULAR PHARMACOLOGY

Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes

(2008) Adrian Roth et al.   Pharmacogenetics and Genomics