Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases

Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma

(2019) Qiqing Sun et al.   Cancer Cell International

Hepatocyte nuclear factor 4α regulates the expression of intestinal epithelial Na+/H+ exchanger isoform 3

(2018) Saminathan Muthusamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Association between the DNA methylations of POMC, MC4R, and HNF4A and metabolic profiles in the blood of children aged 7–9 years

(2018) Eun Jin Kwon et al.   BMC Pediatrics

Role of conventional immunomarkers, HNF4-α and SATB2, in the differential diagnosis of pulmonary and colorectal adenocarcinomas

(2018) Mark Kriegsmann et al.   HISTOPATHOLOGY

GATA6-positive lung adenocarcinomas are associated with invasive mucinous adenocarcinoma morphology, hepatocyte nuclear factor 4α expression, and KRAS mutations

(2018) Naoki Nakajima et al.   HISTOPATHOLOGY

High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice

(2018) Dongsheng Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interleukin-35 stimulates hepatitis B virus transcription and replication by targeting transcription factor HNF4α

(2018) Na-Na Tao et al.   JOURNAL OF GENERAL VIROLOGY

Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival

(2017) Hua-Lian Hang et al.   EXPERIMENTAL CELL RESEARCH

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

(2017) R. Balfour Sartor et al.   GASTROENTEROLOGY

Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha

(2017) James M. Davison et al.   GENOME RESEARCH

Down-regulation of hepatocyte nuclear factor-4α and defective zonation in livers expressing mutant Z α1-antitrypsin

(2017) Pasquale Piccolo et al.   HEPATOLOGY

Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of β-catenin and hepatocyte nuclear factor 4α in hepatocellular carcinoma

(2017) Azusa Kitao et al.   HEPATOLOGY RESEARCH

An HNF4α–microRNA-194/192 signaling axis maintains hepatic cell function

(2017) Aoi Morimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase

(2017) Yoshifumi Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses

(2017) Jie Deng et al.   Cell Death & Disease

HNF‑4α promotes multidrug resistance of gastric cancer cells through the modulation of cell apoptosis

(2017) Yubo Ma et al.   Oncology Letters

Genomic variants link to hepatitis C racial disparities

(2017) Matthew M. Yeh et al.   Oncotarget

Increased expression of hepatocyte nuclear factor 4 alpha transcribed by promoter 2 indicates a poor prognosis in hepatocellular carcinoma

(2017) Shao-hang Cai et al.   Therapeutic Advances in Gastroenterology

The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2

(2017) Borbála Vető et al.   PLoS One

Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis

(2017) Cristina Baciu et al.   PLoS One

Conjunction of potential G-quadruplex and adjacent cis-elements in the 5′ UTR of hepatocyte nuclear factor 4-alpha strongly inhibit protein expression

(2017) Shangdong Guo et al.   Scientific Reports

Prolonged episodes of hypoglycaemia in HNF4A-MODY mutation carriers with IGT. Evidence of persistent hyperinsulinism into early adulthood

(2016) S. Bacon et al.   ACTA DIABETOLOGICA

Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium

(2016) Benjamin D. Moore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α

(2016) Xiaojun Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HNF-4alpha Negatively Regulates Hepcidin Expression Through BMPR1A in HepG2 Cells

(2016) Wencai Shi et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation

(2016) Ning Wu et al.   CANCER BIOLOGY & THERAPY

HNF-4α regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells

(2016) Shengnan Wei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha

(2016) Seema S. Desai et al.   HEPATOLOGY

Yes-associated protein/TEA domain family member and hepatocyte nuclear factor 4-alpha (HNF4α) repress reciprocally to regulate hepatocarcinogenesis in rats and mice

(2016) Wang-Yu Cai et al.   HEPATOLOGY

Hepatocyte Nuclear Factor-4 Alfa Mutation Associated with Hyperinsulinaemic Hypoglycaemia and Atypical Renal Fanconi Syndrome: Expanding the Clinical Phenotype

(2016) Nicola Improda et al.   Hormone Research in Paediatrics

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function

(2016) Benjamin D. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA methylations of MC4R and HNF4α are associated with increased triglyceride levels in cord blood of preterm infants

(2016) Eun Jin Kwon et al.   MEDICINE

Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells

(2016) Morifumi Hanawa et al.   Stem Cell Reviews and Reports

Apoptosis signal-regulating kinase 1 mediates the inhibitory effect of hepatocyte nuclear factor-4α on hepatocellular carcinoma

(2016) Cai-Feng Jiang et al.   Oncotarget

Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer

(2016) Karthikeyani Chellappa et al.   eLife

Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells

(2016) Morifumi Hanawa et al.   Stem Cell Reviews and Reports

Crosstalk of HNF4 α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids

(2016) Hong Lu   Acta Pharmaceutica Sinica B

Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury

(2016) Jiesi Xu et al.   Scientific Reports

Regulation of hepatocyte identity and quiescence

(2015) Carmen Berasain et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Resetting the transcription factor network reverses terminal chronic hepatic failure

(2015) Taichiro Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Luteolin Inhibits Hepatitis B Virus Replication through Extracellular Signal-Regulated Kinase-Mediated Down-Regulation of Hepatocyte Nuclear Factor 4α Expression

(2015) Lang Bai et al.   MOLECULAR PHARMACEUTICS

A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

(2015) Yang Xu et al.   Nature Communications

Viral non-coding RNA inhibits HNF4α expression in HCV associated hepatocellular carcinoma

(2015) Zhao Wang et al.   Infectious Agents and Cancer

HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer

(2014) Hae Ryung Chang et al.   GUT

Decreased Expression of Hepatocyte Nuclear Factor 4α (Hnf4α)/MicroRNA-122 (miR-122) Axis in Hepatitis B Virus-associated Hepatocellular Carcinoma Enhances Potential Oncogenic GALNT10 Protein Activity

(2014) Qian Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HBx Inhibits CYP2E1 Gene Expression via Downregulating HNF4α in Human Hepatoma Cells

(2014) Hongming Liu et al.   PLoS One

HNF4A immunohistochemistry facilitates distinction between primary and metastatic breast and gastric carcinoma

(2014) R. S. van der Post et al.   VIRCHOWS ARCHIV

Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents

(2013) Chad Walesky et al.   HEPATOLOGY

Quantitative proteomic analysis in HCV-induced HCC reveals sets of proteins with potential significance for racial disparity

(2013) Simon T Dillon et al.   Journal of Translational Medicine

Hepatocyte Nuclear Factor 4  and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus

(2013) X. Li et al.   JOURNAL OF VIROLOGY

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

(2013) Sonja I Berndt et al.   NATURE GENETICS

Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation

(2012) Chad Walesky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

HNF4α Antagonists Discovered by a High-Throughput Screen for Modulators of the Human Insulin Promoter

(2012) Alice Kiselyuk et al.   CHEMISTRY & BIOLOGY

Association between genetic variants in the HNF4A gene and childhood-onset Crohn’s disease

(2012) V Marcil et al.   GENES AND IMMUNITY

Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice

(2012) Jessica A. Bonzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of hepatitis B Virus replication by hepatocyte nuclear factor 4-alpha specific short hairpin RNA

(2012) Fang He et al.   LIVER INTERNATIONAL

IL1β Down-regulation of Sex Hormone-Binding Globulin Production by Decreasing HNF-4α Via MEK-1/2 and JNK MAPK Pathways

(2012) Rafael Simó et al.   MOLECULAR ENDOCRINOLOGY

Overexpression of Hepatocyte Nuclear Factor-4α Initiates Cell Cycle Entry, but Is not Sufficient to Promote β-Cell Expansion in Human Islets

(2012) Sebastian Rieck et al.   MOLECULAR ENDOCRINOLOGY

Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes

(2012) Rasmus Ribel-Madsen et al.   PLoS One

Src tyrosine kinase phosphorylation of nuclear receptor HNF4  correlates with isoform-specific loss of HNF4  in human colon cancer

(2012) K. Chellappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte Nuclear Factor (HNF) 4α Expression Distinguishes Ampullary Cancer Subtypes and Prognosis After Resection

(2011) Florian Ehehalt et al.   ANNALS OF SURGERY

An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis

(2011) Maria Hatziapostolou et al.   CELL

Hepatocyte nuclear factor 4A expression discriminates gastric involvement by metastatic breast carcinomas from primary gastric adenocarcinomas

(2011) Taiga Koyama et al.   HUMAN PATHOLOGY

The Hepatitis E Virus ORF3 Protein Regulates the Expression of Liver-Specific Genes by Modulating Localization of Hepatocyte Nuclear Factor 4

(2011) Vivek Chandra et al.   PLoS One

Hepatocyte Nuclear Factor 4  Suppresses the Development of Hepatocellular Carcinoma

(2010) B.-F. Ning et al.   CANCER RESEARCH

Glucose Control and Lipid Metabolism in African American Patients with Type 2 Diabetes Mellitus and Chronic Hepatitis C Viral Infection

(2010) Julie Samantray et al.   Endocrine Practice

HNF4α and CDH1 are associated with ulcerative colitis in a Dutch cohort

(2010) Suzanne van Sommeren et al.   INFLAMMATORY BOWEL DISEASES

Hepatocyte nuclear factor 4α contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation

(2009) Jean-Philippe Babeu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of the Nuclear Receptors HNF4α, PPARα, and LXRs in the TNFα-Mediated Inhibition of Human Apolipoprotein A-I Gene Expression in HepG2 Cells

(2009) Denis A. Mogilenko et al.   BIOCHEMISTRY

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

Hepatocyte nuclear factor 4  attenuates hepatic fibrosis in rats

(2009) H.-Y. Yue et al.   GUT

Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4α and peroxisome proliferator-activated receptor-α

(2009) Xinqin Kang et al.   HEPATOLOGY

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates

(2009) Carrie E. McCurdy et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential gene expression in normal esophagus and Barrett’s esophagus

(2009) Jacob Wang et al.   JOURNAL OF GASTROENTEROLOGY

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice

(2009) Mathieu Darsigny et al.   PLoS One

Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene

(2008) Chuan Yin et al.   HEPATOLOGY

Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel disease

(2008) Sung-Hoon Ahn et al.   INFLAMMATORY BOWEL DISEASES

Hepatocyte nuclear factor-4α promotes differentiation of intestinal epithelial cells in a coculture system

(2007) Carine R. Lussier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY