Combatting intracellular pathogens using bacteriophage delivery

Phage therapy efficacy: a review of the last 10 years of preclinical studies

(2020) Luís D. R. Melo et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Phage penetration of eukaryotic cells: practical implications

(2020) Maciej Żaczek et al.   Future Virology

Development of a Bacteriophage Cocktail to Constrain the Emergence of Phage-Resistant Pseudomonas aeruginosa

(2020) Yuhui Yang et al.   Frontiers in Microbiology

The Yersinia Phage X1 Administered Orally Efficiently Protects a Murine Chronic Enteritis Model Against Yersinia enterocolitica Infection

(2020) Yibing Xue et al.   Frontiers in Microbiology

Bacteriophage ZCSE2 is a Potent Antimicrobial against Salmonella enterica Serovars: Ultrastructure, Genomics and Efficacy

(2020) Ahmed Mohamed et al.   Viruses-Basel

Bacteriophage K1F targets Escherichia coli K1 in cerebral endothelial cells and influences the barrier function

(2020) Christian Møller-Olsen et al.   Scientific Reports

Examination of the Use of Bacteriophage as an Additive and Determining Its Best Application Method to Control Listeria monocytogenes in a Cooked-Meat Model System

(2020) Hanie Ahmadi et al.   Frontiers in Microbiology

Polymersomes Eradicating Intracellular Bacteria

(2020) Federico Fenaroli et al.   ACS Nano

Antimycobacterial Potential of Mycobacteriophage Under Disease-Mimicking Conditions

(2020) Yeswanth Chakravarthy Kalapala et al.   Frontiers in Microbiology

Unlocking the next generation of phage therapy: the key is in the receptors

(2020) Fernando L Gordillo Altamirano et al.   CURRENT OPINION IN BIOTECHNOLOGY

Phage Therapy in the Postantibiotic Era

(2019) Fernando L. Gordillo Altamirano et al.   CLINICAL MICROBIOLOGY REVIEWS

Fighting Pathogenic Bacteria on Two Fronts: Phages and Antibiotics as Combined Strategy

(2019) Thaysa Leite Tagliaferri et al.   Frontiers in Cellular and Infection Microbiology

Environmental structure drives resistance to phages and antibiotics during phage therapy and to invading lysogens during colonisation

(2019) Jorge A. Moura de Sousa et al.   Scientific Reports

Biomimetic hydroxyapatite nanocrystals are an active carrier for Salmonella bacteriophages

(2019) Andrea Fulgione et al.   International Journal of Nanomedicine

Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria

(2019) Kaitlyn E. Kortright et al.   Cell Host & Microbe

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Biodistribution of Liposome-Encapsulated Bacteriophages and Their Transcytosis During Oral Phage Therapy

(2019) Jennifer Otero et al.   Frontiers in Microbiology

Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages

(2019) Daniel J. Greenwood et al.   SCIENCE

Killing from the inside: Intracellular role of T3SS in the fate of Pseudomonas aeruginosa within macrophages revealed by mgtC and oprF mutants

(2019) Preeti Garai et al.   PLoS Pathogens

Safety and Tolerability of Bacteriophage Therapy for Chronic Rhinosinusitis Due to Staphylococcus aureus

(2019) Mian Li Ooi et al.   JAMA Otolaryngology-Head & Neck Surgery

Prophylaxis of Mycobacterium tuberculosis H37Rv Infection in a Preclinical Mouse Model via Inhalation of Nebulized Bacteriophage D29

(2019) Nicholas B. Carrigy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genomic and Proteomic Characterizations of Sfin-1, a Novel Lytic Phage Infecting Multidrug-Resistant Shigella spp. and Escherichia coli C

(2019) SK Tousif Ahamed et al.   Frontiers in Microbiology

Phage therapy as a renewed therapeutic approach to mycobacterial infections: a comprehensive review

(2019) Taher Azimi et al.   Infection and Drug Resistance

Microencapsulation of Enteric Bacteriophages in a pH-Responsive Solid Oral Dosage Formulation Using a Scalable Membrane Emulsification Process

(2019) Vinner et al.   Pharmaceutics

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

(2019) Kevin Yehl et al.   CELL

Phages amid antimicrobial resistance

(2019) Juliet Roshini Mohan Raj et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Evaluation of the Activity of a Combination of Three Bacteriophages Alone or in Association with Antibiotics on Staphylococcus aureus Embedded in Biofilm or Internalized in Osteoblasts

(2019) Camille Kolenda et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Type I-F CRISPR-Cas resistance against virulent phages results in abortive infection and provides population-level immunity

(2019) Bridget N. J. Watson et al.   Nature Communications

Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection

(2019) Sarah E. Rowe et al.   Nature Microbiology

Advances in Biomaterials for Drug Delivery

(2018) Owen S. Fenton et al.   ADVANCED MATERIALS

Design of a Broad-Range Bacteriophage Cocktail That Reduces Pseudomonas aeruginosa Biofilms and Treats Acute Infections in Two Animal Models

(2018) Francesca Forti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of the Efficiency of Lytic Mycobacteriophage D29 on the Model of M. tuberculosis-Infected Macrophage RAW 264 Cell Line

(2018) M. B. Lapenkova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Vibrio cholerae Outer Membrane Vesicles Inhibit Bacteriophage Infection

(2018) Tamara Reyes-Robles et al.   JOURNAL OF BACTERIOLOGY

Contribution of the Immune Response to Phage Therapy

(2018) Oleg Krut et al.   JOURNAL OF IMMUNOLOGY

Shigella Phages Isolated during a Dysentery Outbreak Reveal Uncommon Structures and Broad Species Diversity

(2018) Sarah M. Doore et al.   JOURNAL OF VIROLOGY

Engineering T7 bacteriophage as a potential DNA vaccine targeting delivery vector

(2018) Hai Xu et al.   Virology Journal

Liposome Entrapment of Bacteriophages Improves Wound Healing in a Diabetic Mouse MRSA Infection

(2018) Sanjay Chhibber et al.   Frontiers in Microbiology

Inhaled bacteriophage-loaded polymeric microparticles ameliorate acute lung infections

(2018) Rachit Agarwal et al.   Nature Biomedical Engineering

Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy

(2018) Sazid Hussain et al.   Nature Biomedical Engineering

Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments

(2018) R. Trastoy et al.   CLINICAL MICROBIOLOGY REVIEWS

Nanoencapsulation of Bacteriophages in Liposomes Prepared Using Microfluidic Hydrodynamic Flow Focusing

(2018) Salvatore Cinquerrui et al.   Frontiers in Microbiology

The great escape: how cationic polyplexes overcome the endosomal barrier

(2018) Tanja Bus et al.   Journal of Materials Chemistry B

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

(2018) Patrick Jault et al.   LANCET INFECTIOUS DISEASES

Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System

(2018) Jonas Van Belleghem et al.   Viruses-Basel

Engineered K1F bacteriophages kill intracellular Escherichia coli K1 in human epithelial cells

(2018) Christian Møller-Olsen et al.   Scientific Reports

Particle engineering for intracellular delivery of vancomycin to methicillin-resistant Staphylococcus aureus (MRSA)-infected macrophages

(2017) Yihua Pei et al.   JOURNAL OF CONTROLLED RELEASE

Isolation and Characterization of Listeria phages for Control of Growth of Listeria monocytogenes in Milk

(2017) Sunhee Lee et al.   Korean Journal for Food Science of Animal Resources

Persistent bacterial infections and persister cells

(2017) Robert A. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers

(2017) Sophie Nguyen et al.   mBio

Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells

(2017) Timo A. Lehti et al.   Nature Communications

Evaluation of lytic bacteriophages for control of multidrug-resistant Salmonella Typhimurium

(2017) Lae-seung Jung et al.   Annals of Clinical Microbiology and Antimicrobials

Bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomized, placebo-controlled, double-blind clinical trial

(2017) Lorenz Leitner et al.   BMC Urology

Microencapsulation with alginate/CaCO3: A strategy for improved phage therapy

(2017) Joan Colom et al.   Scientific Reports

The Presence of Two Receptor-Binding Proteins Contributes to the Wide Host Range of Staphylococcal Twort-Like Phages

(2016) Ippei Takeuchi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Targeting the hard to reach: challenges and novel strategies in the treatment of intracellular bacterial infections

(2016) Nor Fadhilah Kamaruzzaman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

(2016) Nazila Kamaly et al.   CHEMICAL REVIEWS

Characterization of differential pore-forming activities of ESAT-6 proteins fromMycobacterium tuberculosisandMycobacterium smegmatis

(2016) Xiuli Peng et al.   FEBS LETTERS

Fluorescent Reporter DS6A Mycobacteriophages Reveal Unique Variations in Infectibility and Phage Production in Mycobacteria

(2016) Oren Mayer et al.   JOURNAL OF BACTERIOLOGY

In vitro evaluation of a novel bacteriophage cocktail as a preventative for bovine coliform mastitis

(2016) J. Porter et al.   JOURNAL OF DAIRY SCIENCE

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Genetically manipulated phages with improved pH resistance for oral administration in veterinary medicine

(2016) Franklin L. Nobrega et al.   Scientific Reports

Broad-Spectrum Antimicrobial Star Polycarbonates Functionalized with Mannose for Targeting Bacteria Residing inside Immune Cells

(2016) Chuan Yang et al.   Advanced Healthcare Materials

Bacteriophage T4 Infection of Stationary Phase E. coli: Life after Log from a Phage Perspective

(2016) Daniel Bryan et al.   Frontiers in Microbiology

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

(2016) Shafiqul Alam Sarker et al.   EBioMedicine

Encapsulation of Bacteriophage in Liposome Accentuates Its Entry in to Macrophage and Shields It from Neutralizing Antibodies

(2016) Saloni Singla et al.   PLoS One

Experimental Phage Therapy for Burkholderia pseudomallei Infection

(2016) Ong Guang-Han et al.   PLoS One

Mycobacterial escape from macrophage phagosomes to the cytoplasm represents an alternate adaptation mechanism

(2016) Shilpa V. Jamwal et al.   Scientific Reports

A first step toward liposome-mediated intracellular bacteriophage therapy

(2015) Anita Nieth et al.   Expert Opinion on Drug Delivery

Mammalian Host-Versus-Phage immune response determines phage fate in vivo

(2015) Katarzyna Hodyra-Stefaniak et al.   Scientific Reports

Targeting glioblastoma via intranasal administration of Ff bacteriophages

(2015) Eyal Dor-On et al.   Frontiers in Microbiology

Bacteriophage-aided intracellular killing of engulfed methicillin-resistant Staphylococcus aureus (MRSA) by murine macrophages

(2014) Sandeep Kaur et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bacteriophage-based synthetic biology for the study of infectious diseases

(2014) Robert J Citorik et al.   CURRENT OPINION IN MICROBIOLOGY

Factors Affecting Phage D29 Infection: A Tool to Investigate Different Growth States of Mycobacteria

(2014) Benjamin M. C. Swift et al.   PLoS One

Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

(2014) S. Helaine et al.   SCIENCE

Probing the Endocytic Pathways of the Filamentous Bacteriophage in Live Cells Using Ratiometric pH Fluorescent Indicator

(2014) Ye Tian et al.   Advanced Healthcare Materials

Chlamydia bacteriophages

(2013) Joanna Śliwa-Dominiak et al.   ARCHIVES OF MICROBIOLOGY

A review of the biomaterials technologies for infection-resistant surfaces

(2013) Davide Campoccia et al.   BIOMATERIALS

Biopolymer-Based Nanoparticles for Drug/Gene Delivery and Tissue Engineering

(2013) Sachiko Nitta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic modifications to temperate Enterococcus faecalis phage  Ef11 that abolish the establishment of lysogeny and sensitivity to repressor, and increase host range and productivity of lytic infection

(2013) H. Zhang et al.   MICROBIOLOGY-SGM

Lysogenic Conversion and Phage Resistance Development in Phage Exposed Escherichia coli Biofilms

(2013) Pieter Moons et al.   Viruses-Basel

CRISPR-Cas and restriction–modification systems are compatible and increase phage resistance

(2013) Marie-Ève Dupuis et al.   Nature Communications

Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response

(2013) Sarah Schmidt Grant et al.   Virulence

A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens

(2013) Xavier Wittebole et al.   Virulence

Entry of Listeria monocytogenes in Mammalian Epithelial Cells: An Updated View

(2013) J. Pizarro-Cerda et al.   Cold Spring Harbor Perspectives in Medicine

Chlamydial Intracellular Survival Strategies

(2013) R. J. Bastidas et al.   Cold Spring Harbor Perspectives in Medicine

Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model

(2013) Gabriela Trigo et al.   PLoS Neglected Tropical Diseases

Engineered phage-based therapeutic materials inhibit Chlamydia trachomatis intracellular infection

(2012) Shanta Raj Bhattarai et al.   BIOMATERIALS

Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling

(2012) Eric C. Freeman et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

A Method for Generation Phage Cocktail with Great Therapeutic Potential

(2012) Jingmin Gu et al.   PLoS One

The Bimodal Lifestyle of Intracellular Salmonella in Epithelial Cells: Replication in the Cytosol Obscures Defects in Vacuolar Replication

(2012) Preeti Malik-Kale et al.   PLoS One

Cellular Internalization Mechanism and Intracellular Trafficking of Filamentous M13 Phages Displaying a Cell-Penetrating Transbody and TAT Peptide

(2012) Aeyung Kim et al.   PLoS One

Intracellular staphylococcus aureus: Live-in and let die

(2012) Martin Fraunholz et al.   Frontiers in Cellular and Infection Microbiology

Targeted delivery of antibiotics to intracellular chlamydial infections using PLGA nanoparticles

(2011) Udaya S. Toti et al.   BIOMATERIALS

Contribution of bacterial outer membrane vesicles to innate bacterial defense

(2011) Andrew J Manning et al.   BMC MICROBIOLOGY

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

The Role of Reactive-Oxygen-Species in Microbial Persistence and Inflammation

(2011) Ralee Spooner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antimicrobial Actions of Reactive Oxygen Species

(2011) F. C. Fang   mBio

Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin againstStaphylococcus aureus

(2010) Sandrine Lemaire et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The complete genome sequence and proteomics of Yersinia pestis phage Yep-phi

(2010) X. Zhao et al.   JOURNAL OF GENERAL VIROLOGY

Restriction–modification systems and bacteriophage invasion: Who wins?

(2010) Farida N. Enikeeva et al.   JOURNAL OF THEORETICAL BIOLOGY

Role of the Mycobacterium tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth

(2009) S. Ramon-Garcia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional Genomic Analysis of Two Staphylococcus aureus Phages Isolated from the Dairy Environment

(2009) P. Garcia et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Salmonella- the ultimate insider.Salmonellavirulence factors that modulate intracellular survival

(2009) J. Antonio Ibarra et al.   CELLULAR MICROBIOLOGY

Site-specific recombination of T2 phage using IP008 long tail fiber genes provides a targeted method for expanding host range while retaining lytic activity

(2009) Faezeh Mahichi et al.   FEMS MICROBIOLOGY LETTERS

Quality-Controlled Small-Scale Production of a Well-Defined Bacteriophage Cocktail for Use in Human Clinical Trials

(2009) Maya Merabishvili et al.   PLoS One

Virulent Bacteriophage for Efficient Biocontrol of Listeria monocytogenes in Ready-To-Eat Foods

(2008) S. Guenther et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Microencapsulation of Bacteriophage Felix O1 into Chitosan-Alginate Microspheres for Oral Delivery

(2008) Y. Ma et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cellular responses to reactive oxygen species-induced DNA damage and aging

(2008) Catharina Bertram et al.   BIOLOGICAL CHEMISTRY

A freeze-dried formulation of bacteriophage encapsulated in biodegradable microspheres

(2008) U. Puapermpoonsiri et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

PEGylation of bacteriophages increases blood circulation time and reduces T-helper type 1 immune response

(2008) Kwang-Pyo Kim et al.   Microbial Biotechnology

Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats

(2007) Wassana Wijagkanalan et al.   JOURNAL OF CONTROLLED RELEASE