Next-generation probiotics: a promising approach towards designing personalized medicine

Recombinant Lactococcus lactis co-expressing dendritic cell target peptide and E. tenella 3-1E protein: immune response and efficacy against homologous challenge

(2020) Guanghao Li et al.   FOOD AND AGRICULTURAL IMMUNOLOGY

An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway

(2020) Lishan Zeng et al.   Journal of Translational Medicine

Engineered Recombinant Escherichia coli Probiotic Strains Integrated with F4 and F18 Fimbriae Cluster Genes in the Chromosome and Their Assessment of Immunogenic Efficacy in Vivo

(2020) Bingming Ou et al.   ACS Synthetic Biology

High protection of mice against Brucella abortus by oral immunization with recombinant probiotic Lactobacillus casei vector vaccine, expressing the outer membrane protein OMP19 of Brucella species

(2020) Elham Mohammadi et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Engineered and wild-type L. lactis promote anti-inflammatory cytokine signalling in inflammatory bowel disease patient’s mucosa

(2019) Saša Simčič et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

TRAIL Expressing Recombinant Lactococcus lactis Induces Apoptosis in Human Colon Adenocarcinoma SW480 and HCT116 Cells

(2019) Ebrahim Bohlul et al.   JOURNAL OF APPLIED MICROBIOLOGY

In vitro assessment of pediococci- and lactobacilli-induced cholesterol-lowering effect using digitally enhanced high-performance thin-layer chromatography and confocal microscopy

(2019) Rohawi Nur Syakila et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Genetically engineered probiotic Saccharomyces cerevisiae strains mature human dendritic cells and stimulate Gag-specific memory CD8+ T cells ex vivo

(2019) Mariana L. Palma et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recombinant lactococcus lactis secreting viral protein 1 of enterovirus 71 and its immunogenicity in mice

(2019) Pengwei Xu et al.   BIOTECHNOLOGY LETTERS

Potential roles of gut microbiome and metabolites in modulating ALS in mice

(2019) Eran Blacher et al.   NATURE

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

(2019) Clea Bárcena et al.   NATURE MEDICINE

Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis

(2019) Eduard Ansaldo et al.   SCIENCE

Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

(2019) Chandran Ramakrishna et al.   Nature Communications

Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy

(2019) Lian He et al.   Journal of Biological Engineering

Expression of Human ACE2 in Lactobacillus and Beneficial Effects in Diabetic Retinopathy in Mice

(2019) Amrisha Verma et al.   Molecular Therapy-Methods & Clinical Development

Preliminary safety assessment of a new Bacteroides fragilis isolate

(2019) Huizi Tan et al.   FOOD AND CHEMICAL TOXICOLOGY

The first clinical use of a recombinant Lactococcus lactis expressing human papillomavirus type 16 E7 oncogene oral vaccine: A phase I safety and immunogenicity trial in healthy women volunteers

(2019) Amir Hossein Mohseni et al.   MOLECULAR CANCER THERAPEUTICS

Impact of oral probiotic Lactobacillus acidophilus vaccine strains on the immune response and gut microbiome of mice

(2019) Zaid Abdo et al.   PLoS One

Engineered commensal bacteria prevent systemic inflammation-induced memory impairment and amyloidogenesis via producing GLP-1

(2018) Tingtao Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recombinant Probiotics Expressing Angiotensin-(1-7) Improves Glucose Metabolism and Diabetes-Induced Renal and Retinal Injury

(2018) QIUHONG LI et al.   DIABETES

Gut commensalParabacteroides goldsteiniiplays a predominant role in the anti-obesity effects of polysaccharides isolated fromHirsutella sinensis

(2018) Tsung-Ru Wu et al.   GUT

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Gut Microbiota: An Integral Moderator in Health and Disease

(2018) Qingqing Feng et al.   Frontiers in Microbiology

Lactobacillus Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens

(2018) Jonathan S. LeCureux et al.   mSphere

Genome Editing with CRISPR-Cas9 in Lactobacillus plantarum Revealed That Editing Outcomes Can Vary Across Strains and Between Methods

(2018) Ryan T. Leenay et al.   Biotechnology Journal

The Human Gut Microbiome – A Potential Controller of Wellness and Disease

(2018) Zhi Y. Kho et al.   Frontiers in Microbiology

The Genus Enterococcus: Between Probiotic Potential and Safety Concerns—An Update

(2018) Hasna Hanchi et al.   Frontiers in Microbiology

Safety aspects of next generation probiotics

(2018) Maria H Saarela   Current Opinion in Food Science

Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants

(2018) S Graspeuntner et al.   CLINICAL INFECTIOUS DISEASES

Reactivity toward Bifidobacterium longum and Enterococcus hirae demonstrate robust CD8 + T cell response and better prognosis in HBV-related hepatocellular carcinoma

(2017) Yihui Rong et al.   EXPERIMENTAL CELL RESEARCH

Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics

(2017) Mireia Lopez-Siles et al.   ISME Journal

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

(2017) Anna Heintz-Buschart et al.   MOVEMENT DISORDERS

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid

(2017) María V. Selma et al.   Frontiers in Microbiology

Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic

(2017) Rebeca Martín et al.   Frontiers in Microbiology

Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

(2017) Paul W. O’Toole et al.   Nature Microbiology

The Human Microbiota in Health and Disease

(2017) Baohong Wang et al.   Engineering

Allogeneic stem cell transplantation for HIV-positive patients with hematologic malignancies

(2016) Victor E. Mulanovich et al.   AIDS

Genetic Determinants of the Gut Microbiome in UK Twins

(2016) Julia K. Goodrich et al.   Cell Host & Microbe

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

(2016) Filipe De Vadder et al.   Cell Metabolism

Akkermansia MuciniphilaProtects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation inApoe−/−MiceCLINICAL PERSPECTIVE

(2016) Jin Li et al.   CIRCULATION

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

(2016) Romain Daillère et al.   IMMUNITY

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

(2016) J-Y Yang et al.   Mucosal Immunology

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

A novel strain of Bacteroides fragilis enhances phagocytosis and polarises M1 macrophages

(2016) Huimin Deng et al.   Scientific Reports

Impact of oral consumption of heat-treated Bacteroides xylanisolvens DSM 23964 on the level of natural TFα-specific antibodies in human adults

(2016) P. Ulsemer et al.   Beneficial Microbes

Bacteroides fragilis Lipopolysaccharide and Inflammatory Signaling in Alzheimer’s Disease

(2016) Walter J. Lukiw   Frontiers in Microbiology

The Common Gut Microbe Eubacterium hallii also Contributes to Intestinal Propionate Formation

(2016) Christina Engels et al.   Frontiers in Microbiology

Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota

(2016) Jonathan M. Pitt et al.   OncoImmunology

Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

(2016) Shanthadevi Udayappan et al.   npj Biofilms and Microbiomes

Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of Diabetes

(2015) Franklin F. Duan et al.   DIABETES

Regulatory categories of probiotics across the globe: A review representing existing and recommended categorization

(2015) A Baldi et al.   Indian Journal of Medical Microbiology

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

(2015) Marc Schneeberger et al.   Scientific Reports

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

From Stool Transplants to Next-Generation Microbiota Therapeutics

(2014) Elaine O. Petrof et al.   GASTROENTEROLOGY

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

A Novel Regulatory T Cell Population in the Gut

(2014) Caitlin Sedwick   PLOS BIOLOGY

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

(2013) Laura Wrzosek et al.   BMC BIOLOGY

Specific humoral immune response to the Thomsen-Friedenreich tumor antigen (CD176) in mice after vaccination with the commensal bacterium Bacteroides ovatus D-6

(2013) Philippe Ulsemer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Faecalibacterium prausnitzii and human intestinal health

(2013) S Miquel et al.   CURRENT OPINION IN MICROBIOLOGY

Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8

(2013) MASAHIDE SHINNOH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives

(2013) I. Kahouli et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Designing probiotics with respect to the native microbiome

(2012) Abolfazl Barzegari et al.   Future Microbiology

IgA production in the large intestine is modulated by a different mechanism than in the small intestine: Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells

(2012) Tsutomu Yanagibashi et al.   IMMUNOBIOLOGY

Recombinant Probiotic Expressing Listeria Adhesion Protein Attenuates Listeria monocytogenes Virulence In Vitro

(2012) Ok Kyung Koo et al.   PLoS One

Bacteroides uniformis CECT 7771 Ameliorates Metabolic and Immunological Dysfunction in Mice with High-Fat-Diet Induced Obesity

(2012) Paola Gauffin Cano et al.   PLoS One

Mucosal Vaccination and Therapy with Genetically Modified Lactic Acid Bacteria

(2012) Jerry Wells   Annual Review of Food Science and Technology

Preliminary Safety Evaluation of a New Bacteroides xylanisolvens Isolate

(2011) Philippe Ulsemer et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhanced Wound Healing by Recombinant Escherichia coli Nissle 1917 via Human Epidermal Growth Factor Receptor in Human Intestinal Epithelial Cells: Therapeutic Implication Using Recombinant Probiotics

(2011) Hye Jin Choi et al.   INFECTION AND IMMUNITY

Inhibition of the cytotoxic effect of Clostridium difficile in vitro by Clostridium butyricum MIYAIRI 588 strain

(2011) T. D. H. Woo et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Intragastric administration of a superoxide dismutase-producing recombinant Lactobacillus casei BL23 strain attenuates DSS colitis in mice

(2010) Laurie Watterlot et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats

(2009) R. K. Le Leu et al.   CARCINOGENESIS

Beneficial effects of Bacteroides fragilis polysaccharides on the immune system

(2009) Erin et al.   Frontiers in Bioscience-Landmark

Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

(2008) Jerry M. Wells et al.   NATURE REVIEWS MICROBIOLOGY