4.3 Review

Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives

Journal

JOURNAL OF MEDICAL MICROBIOLOGY
Volume 62, Issue -, Pages 1107-1123

Publisher

MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.048975-0

Keywords

-

Categories

Funding

  1. Canadian Institutes of Health Research (CIHR) MOP [64308]
  2. George G. Harris Fellowship Program
  3. NSERC

Ask authors/readers for more resources

Colorectal cancer (CRC) is the third most common form of cancer. Diverse therapies such as chemotherapy, immunotherapy and radiation have shown beneficial effects, but are limited because of their safety and toxicity. Probiotic formulations have shown great promise in CRC as preventive and early stage therapeutics. This review highlights the importance of a balanced intestinal microbiota and summarizes the recent developments in probiotics for treating CRC. Specifically, this report describes evidence of the role of probiotics in modulating the microbiota, in improving the physico-chemical conditions of the gut and in reducing oxidative stress. It also discusses the mechanisms of probiotics in inhibiting tumour progression, in producing anticancer compounds and in modulating the host immune response. Even though some of these effects were observed in several clinical trials, when probiotic formulations were used as a supplement to CRC therapies, the application of probiotics as biotherapeutics against CRC still needs further investigation.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available