Article
Pharmacology & Pharmacy
Binxin Cui, Lin Lin, Bangmao Wang, Wentian Liu, Chao Sun
Summary: This review focuses on the therapeutic potential and mechanisms of S. boulardii as a probiotic, and summarizes its potential efficacy in various liver diseases and future prospects.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Food Science & Technology
Adam Staniszewski, Monika Kordowska-Wiater
Summary: The paper discusses the concept of probiotic yeasts and their application in functional foods, emphasizing their positive impact on health, and pointing out future research directions.
Review
Microbiology
Nicanor Austriaco
Summary: Currently, orally delivered vaccines have advantages over injected vaccines, but approved oral vaccines are limited to diseases that affect the gastrointestinal tract or crucial life cycle stages in the gut. All approved oral vaccines involve live-attenuated or inactivated pathogens. This mini-review explores the potential and challenges of yeast oral vaccine delivery systems for animal and human infectious diseases.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Food Science & Technology
Adam Staniszewski, Monika Kordowska-Wiater
Summary: One approach to maintaining a healthy microbiota in the human gastrointestinal tract is through the consumption of probiotics. This study examined the probiotic potential of yeast strains isolated from Polish wines. The tested strains belonged to six different species and were evaluated for their probiotic properties, safety, enzymatic activity, and antioxidant properties. The results showed that certain strains of H. uvarum, M. pulcherrima, and S. cerevisiae exhibited promising probiotic characteristics.
Article
Biochemical Research Methods
Pedro A. Baldera-Aguayo, Arden Lee, Virginia W. Cornish
Summary: Antibiotic resistance is a global health threat, and developing new tetracycline analogue therapeutics is urgent. By engineering yeast, researchers have successfully produced the fungal tetracycline TAN-1612 and significantly increased its yield. This study marks an important step in combating antibiotic resistance.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Nathalie Le Floc'h, Caroline Stephanie Achard, Francis Amann Eugenio, Emmanuelle Apper, Sylvie Combes, Helene Quesnel
Summary: Feeding sows with live yeast Saccharomyces cerevisiae var. boulardii (SB) can influence the fecal microbiota of sows and their piglets, but does not have an effect on their health and performance.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Food Science & Technology
Jimmy G. Hernandez-Gomez, Argelia Lopez-Bonilla, Gabriela Trejo-Tapia, Sandra V. Avila-Reyes, Antonio R. Jimenez-Aparicio, Humberto Hernandez-Sanchez
Summary: The study evaluated the BSH activity in six probiotic strains, including five lactic acid bacteria and one probiotic yeast. Results showed that Lactobacillus plantarum DGIA1 and Saccharomyces boulardii exhibited excellent deconjugation activities against bile acids, with the yeast showing BSH activity for the first time. This finding highlights the potential of these probiotic strains in regulating cholesterol levels.
Article
Medicine, General & Internal
Jaime Altcheh, Mabel V. Carosella, Ana Ceballos, Ulises D'Andrea, Sandra M. Jofre, Carolina Marotta, Domingo Mugeri, Liliana Sabbaj, Adriana Soto, Constant Josse, Francois Montestruc, Lynne V. McFarland
Summary: This study compared the efficacy and safety of two probiotics for pediatric acute diarrhea. The results showed that Saccharomyces boulardii CNCM I-745 demonstrated better efficacy than a four-strain mixture of Bacillus clausii for reducing the duration of diarrhea.
Article
Biotechnology & Applied Microbiology
Yerin Jin, Sora Yu, Jing-Jing Liu, Eun Ju Yun, Jae Won Lee, Yong-Su Jin, Kyoung Heon Kim
Summary: In this study, the probiotic yeast S. boulardii was engineered to produce health-beneficial neoagarooligosaccharides (NAOSs) by expressing an endo-type beta-agarase, BpGH16A, derived from a human gut bacterium Bacteroides plebeius. The results suggest that engineered S. boulardii can be considered a microbial cell factory for producing useful substances in the human gut, with successful production of health-benefiting NeoDP4 from agarose.
MICROBIAL CELL FACTORIES
(2021)
Review
Biotechnology & Applied Microbiology
Jyoti Prakash Tamang, Sonam Lama
Summary: This review article provides information on the presence of potential probiotic yeasts in some traditional fermented foods and beverages.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Pedro Pais, Jorge Oliveira, Vanda Almeida, Melike Yilmaz, Pedro T. Monteiro, Miguel C. Teixeira
Summary: The study found that S. cerevisiae var. boulardii exhibited higher survival capability and acetate biosynthesis in an intestinal-like medium compared to S. cerevisiae, possibly related to its probiotic activity. Analysis of a genomic database for S. cerevisiae var. boulardii suggested a potential link between variations in transcription factor binding sites and transcriptomic patterns.
Article
Food Science & Technology
Shohreh Nasiri Poroj, Mohaddeseh Larypoor, Mohammad Reza Fazeli, Farid Shariatmadari
Summary: This study investigated the reduction of aflatoxin by yeast strains isolated from fermented products and titanium dioxide nanoparticles. The selected yeast strains showed probiotic and antimicrobial activity, as well as enhanced aflatoxin reduction when combined with TiO2-NPs.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biology
Nina Okuka, Verena Schuh, Ulrike Krammer, Snezana Polovina, Mirjana Sumarac-Dumanovic, Neda Milinkovic, Ksenija Velickovic, Brizita Djordjevic, Alexander Haslberger, Nevena Dj. Ivanovic
Summary: This study investigates the effect of a novel probiotic approach combined with hypocholesterolemic octacosanol on the expression of specific miRNAs and mRNAs associated with obesity. The results show that this approach has a regulatory effect on the expression of certain miRNAs and mRNAs, which are important for obesity onset and control.
Review
Fisheries
Juana Cristina del Valle, Maria Cecilia Bonadero, Analia Veronica Fernandez-Gimenez
Summary: Aquaculture is the fastest-growing food production area in the world. The use of probiotics, prebiotics, synbiotics, and parabiotics as alternatives to regular feed has been proven to improve the growth, immunity, and gut health of cultured species. Yeasts, particularly Saccharomyces cerevisiae, have shown health stimulating effects in various cultured species. However, the research on the application of S. cerevisiae in aquaculture has not been fully integrated, and this review aims to fill that gap and provide insights for future investigations.
Article
Biology
Abraham Majak Gut, Todor Vasiljevic, Thomas Yeager, Osaana N. Donkor
Summary: The study focused on comparing adhesion properties and antibacterial metabolites produced by Kluyveromyces lactis and Saccharomyces unisporus isolated from traditional kefir grains with Saccharomyces boulardii strains. It was found that Kluyveromyces lactis and Saccharomyces unisporus have anti-Salmonella effects comparable to Saccharomyces boulardii strains, indicating their potential in controlling Salmonella infection.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
M. R. S. Ribeiro, D. R. Oliveira, M. V. Caliari, D. C. Cara Machado, M. E. R. Andrade, V. N. Cardoso, F. dos Santos Martins, J. R. Nicoli, M. A. Gomes
Summary: This study evaluated the effect of treatment with the probiotic Saccharomyces boulardii with or without metronidazole in experimental giardiasis, finding a significant reduction in parasitic load and protection against intestinal mucosal damage and oxidative stress. The results suggest the potential use of S. boulardii as an alternative treatment for giardiasis, especially in cases of resistance or intolerance to conventional treatment.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Environmental Sciences
Giuseppina Di Martino, Salvatore Pasqua, Bruno Douradinha, Francesco Monaco, Chiara Di Bartolo, Pier Giulio Conaldi, Danilo D'Apolito
Summary: The study evaluated and validated the efficacy of disinfectants to reduce pharmaceutical hospital surfaces' contaminations. Testing three commercial disinfectants on representative samples, the study developed a successful disinfection procedure decreasing microbial load and preventing propagation of microorganisms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biotechnology & Applied Microbiology
Spencer S. Santos, Vivian C. Miranda, Luisa M. Trindade, Valbert N. Cardoso, Diego C. Reis, Geovanni D. Cassali, Jacques R. Nicoli, Denise C. Cara, Flaviano S. Martins
Summary: This study evaluated the probiotic effect of Bifidobacterium longum subsp. longum 5(1A) in a murine model of food allergy. The results showed that oral administration of this probiotic prevented weight loss, reduced immune reactions, and improved intestinal permeability. The dose of 10^8 CFU showed the best protective effect, and the use of live bacteria was necessary to achieve these beneficial effects.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Biochemistry & Molecular Biology
Maria Giovanna Francipane, Bruno Douradinha, Cinzia Maria Chinnici, Giovanna Russelli, Pier Giulio Conaldi, Gioacchin Iannolo
Summary: Glioblastoma (GBM) is an aggressive neurological tumor with no effective long-term treatment options. The discovery of Zika virus (ZIKV) having oncolytic effects against GBM has led to hopes for new therapeutic approaches, but further research on its mechanisms of action is necessary for potential clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mariangela Pampalone, Giampiero Vitale, Salvatore Gruttadauria, Giandomenico Amico, Gioacchin Iannolo, Bruno Douradinha, Alessandra Mularoni, Pier Giulio Conaldi, Giada Pietrosi
Summary: This study demonstrates the potential usefulness of hA-MSCs in treating carbapenem-resistant bacterial infections in ascites, with significant effects on bacterial load and immune factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Quesia S. Damaceno, Bruno Gallotti, Isabela M. M. Reis, Yasmim C. P. Totte, Gabriella B. Assis, Henrique C. Figueiredo, Tales F. Silva, Vasco Azevedo, Jacques R. Nicoli, Flaviano S. Martins
Summary: Breast milk contains beneficial bacteria that can positively influence the health of newborns. The study identified 77 bacteria belonging to four genera, including Staphylococcus, Streptococcus, Leuconostoc, and Lacticaseibacillus. Two potential probiotics, Lacticaseibacillus rhamnosus and Leuconostoc mesenteroides, were selected and found to colonize the gastrointestinal tract in germ-free mice and maintain viability after spray-drying.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Gastroenterology & Hepatology
Ester Badami, Rosalia Busa, Bruno Douradinha, Giovanna Russelli, Vitale Miceli, Alessia Gallo, Giovanni Zito, Pier Giulio Conaldi, Gioacchin Iannolo
Summary: This review summarizes the current knowledge on the association between miRNA, HCV, and HCC, with a focus on diagnostic perspectives and potential implications for therapeutic approaches.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Letter
Dermatology
Maria Cecilia Campos Canesso, Puebla Cassini-Vieira, Camila Francisco Moreira, Suzanne Luong, Milene Alvarenga Rachid, Flaviano Santos Martins, Mauro Martins Teixeira, Angelica Thomas Vieira, Charles Reay Mackay, Luciola Silva Barcelos
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Vivian C. Miranda, Ramon O. Souza, Monica F. Quintanilha, Bruno Gallotti, Helder C. Assis, Ana Maria C. Faria, Jacques R. Nicoli, Denise C. Cara, Flaviano S. Martins
Summary: This study aimed to evaluate the probiotic and postbiotic potential of Akkermansia muciniphila BAA-835 in an ovalbumin food allergy model. The results showed that treatment with viable A. muciniphila could alleviate weight loss, decrease serum levels of allergy-related antibodies, reduce intestinal injury and inflammation, and modify the gut microbiota composition. Additionally, the administration of inactivated bacteria also had a postbiotic effect by reducing allergy-related immune responses. These findings suggest that A. muciniphila BAA-835 has both probiotic and postbiotic properties in the prevention and treatment of food allergies.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Virology
Bruno Douradinha
JOURNAL OF VIROLOGY
(2023)
Editorial Material
Parasitology
Bruno Douradinha
Summary: The pro-apoptotic action of peroxynitrite may contribute to the attenuated protection mediated by malarial sporozoite.
TRENDS IN PARASITOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bruno Douradinha
Summary: Plasmodium sporozoites can inhibit apoptosis in host hepatocytes, ensuring parasite survival. However, attenuated sporozoites are unable to prevent apoptosis, leading to exposure of parasite antigens to immune cells, thus providing protection against Malaria. This protection mechanism may involve hydrogen peroxide-induced apoptosis. The hypothesis is supported by the relationship between Plasmodium, hydrogen peroxide, and apoptosis described in published studies.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2023)
Article
Immunology
Alberto Cagigi, Bruno Douradinha
Summary: This article extensively explores the history, mechanisms, strengths, and limitations of genetic vaccines, and highlights ongoing research for potential enhancement of both DNA and mRNA vaccines.
EXPERT REVIEW OF VACCINES
(2023)
Article
Biochemistry & Molecular Biology
Nicola Cuscino, Ayesha Fatima, Vincenzo Di Pilato, Matteo Bulati, Caterina Alfano, Elisa Monaca, Giuseppina Di Mento, Daniele Di Carlo, Francesca Cardinale, Francesco Monaco, Gian Maria Rossolini, Asif M. Khan, Pier Giulio Conaldi, Bruno Douradinha
Summary: Research conducted a reverse vaccinology approach to identify potential multiepitope vaccine candidates against carbapenem-resistant Klebsiella pneumoniae. Bioinformatics tools were used to analyze their antigenicity and other characteristics, and demonstrated their interaction with immune receptors. A recombinant vaccine was produced using a codon optimization cloning strategy, and immunization simulations showed induced immune responses.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Surgery
Eline Lima Borges, Gilmara Lopes Amorim, Marina Barcelos de Miranda, Flaviano dos Santos Martins, Antonio Carlos Martins Guedes, Kinulpe Honorato Sampaio, Josimare Aparecida Otoni Spira, Luciola da Silva Barcelos
Summary: This study evaluated a biofilm model of Pseudomonas aeruginosa in mice with excisional cutaneous wounds. The results showed that the presence of biofilms delayed the wound healing process and raised questions about the ease of biofilm formation in chronic wounds.
ACTA CIRURGICA BRASILEIRA
(2022)