Pharmacovigilance‐based drug repurposing: The search for inverse signals via OpenVigil identifies putative drugs against viral respiratory infections

COVID-19: Gastrointestinal manifestations and potential fecal-oral transmission

(2020) Jinyang Gu et al.   GASTROENTEROLOGY

Evidence for gastrointestinal infection of SARS-CoV-2

(2020) Fei Xiao et al.   GASTROENTEROLOGY

Selective Targeting of Virus Replication by Proton Pump Inhibitors

(2020) Susan M. Watanabe et al.   Scientific Reports

Drug repurposing in Raynaud's phenomenon through adverse event signature matching in the World Health Organization pharmacovigilance database

(2020) Putkaradze Zaza et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Outcomes in Patients With Hyperglycemia Affected by Covid-19: Can We Do More on Glycemic Control?

(2020) Celestino Sardu et al.   DIABETES CARE

Diabetes is a risk factor for the progression and prognosis of COVID-19

(2020) Weina Guo et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

(2020) Giuseppe Mancia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

(2020) Harmony R. Reynolds et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes and COVID-19

(2020) Béatrice Bouhanick et al.   THERAPIE

SARS‐CoV‐2, Testosterone and frailty in males (PROTEGGIMI): A multidimensional research project

(2020) Andrea Salonia et al.   Andrology

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications

(2020) Konstantinos Farsalinos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In silico studies on therapeutic agents for COVID-19: Drug repurposing approach

(2020) Bhumi Shah et al.   LIFE SCIENCES

Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019

(2020) Fabian Sanchis-Gomar et al.   MAYO CLINIC PROCEEDINGS

Commentary: Testosterone, a key hormone in the context of COVID-19 pandemic

(2020) Paolo Pozzilli et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

(2020) David R. Boulware et al.   NEW ENGLAND JOURNAL OF MEDICINE

Admission hyperglycemiaas a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: Data from the Spanish SEMI-COVID-19 Registry

(2020) Francisco Javier Carrasco-Sánchez et al.   ANNALS OF MEDICINE

Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19

(2020) Carina Conzelmann et al.   CLINICAL MEDICINE

Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis

(2020) Krzysztof Marciniec et al.   Pharmacological Reports

Repurposing existing drugs for COVID-19: an endocrinology perspective

(2020) Flavio A. Cadegiani   BMC Endocrine Disorders

Evidence for treatment with estradiol for women with SARS-CoV-2 infection

(2020) Ute Seeland et al.   BMC Medicine

Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

(2020) Basile Chrétien et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Design, optimization, characterization, and in vivo evaluation of sterosomes as a carrier of metformin for treatment of lung cancer

(2019) Hasnaa Osama et al.   JOURNAL OF LIPOSOME RESEARCH

Peroxisome Proliferator-Activated Receptor-gamma agonists exhibit anti-inflammatory and antiviral effects in an EcoHIV mouse model

(2019) Amila Omeragic et al.   Scientific Reports

Signal of potentially protective drug–drug interactions from spontaneous reporting systems: proceed with caution

(2019) Ippazio Cosimo Antonazzo et al.   ACTA DIABETOLOGICA

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment

(2018) Szu-Yuan Pu et al.   ANTIVIRAL RESEARCH

Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors

(2018) Jeanne M. Sisk et al.   JOURNAL OF GENERAL VIROLOGY

Activities of Thrombin and Factor Xa Are Essential for Replication of Hepatitis E Virus and Are Possibly Implicated in ORF1 Polyprotein Processing

(2018) Gayatri D. Kanade et al.   JOURNAL OF VIROLOGY

An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs

(2018) Kouichi Hosomi et al.   PLoS One

Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase

(2017) Wei-Lun Tsai et al.   Oncotarget

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

(2017) Joanne M. Donkers et al.   Scientific Reports

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus

(2017) Jie Zhou et al.   Science Advances

A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site

(2017) Marco R. Straus et al.   PLoS One

Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm

(2017) Yusuke Watanabe et al.   Scientific Reports

Good Signal Detection Practices: Evidence from IMI PROTECT

(2016) Antoni F. Z. Wisniewski et al.   DRUG SAFETY

Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion

(2016) Christopher M. Coleman et al.   JOURNAL OF VIROLOGY

Inhibition of Inflammation-Associated Olfactory Loss by Etanercept in an Inducible Olfactory Inflammation Mouse Model

(2016) Yong Gi Jung et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

(2016) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo

(2015) Wan-Yu Li et al.   ARCHIVES OF VIROLOGY

Comparison of Statistical Signal Detection Methods Within and Across Spontaneous Reporting Databases

(2015) Gianmario Candore et al.   DRUG SAFETY

A review of the current nomenclature for psychotropic agents and an introduction to the Neuroscience-based Nomenclature

(2015) Joseph Zohar et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats

(2015) P. L. M. Dalpiaz et al.   PLoS One

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

(2013) Nianshuang Wang et al.   CELL RESEARCH

Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells

(2013) Y.-H. Xun et al.   JOURNAL OF VIRAL HEPATITIS

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies Peroxisome Proliferator-Activated Receptor Gamma as an intrinsic negative regulator of viral replication

(2013) Annie Bernier et al.   Retrovirology

OpenVigil—free eyeballs on AERS pharmacovigilance data

(2012) Ruwen Böhm et al.   NATURE BIOTECHNOLOGY

Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications

(2011) Aino Soro-Paavonen et al.   JOURNAL OF HYPERTENSION

Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-γ ligand, rosiglitazone

(2010) Yuta Wakui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peroxisome proliferator-activated receptor-γ activation suppresses HIV-1 replication in an animal model of encephalitis

(2009) Raghava Potula et al.   AIDS