Peroxisome Proliferator-Activated Receptor-gamma agonists exhibit anti-inflammatory and antiviral effects in an EcoHIV mouse model

Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice

(2018) Katherine E. Olson et al.   JOURNAL OF NEUROVIROLOGY

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment

(2018) Chao-Jiang Gu et al.   PLoS Pathogens

N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders

(2017) Michael T. Nedelcovych et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peroxisome proliferator-activated receptor-gamma: potential molecular therapeutic target for HIV-1-associated brain inflammation

(2017) Amila Omeragic et al.   Journal of Neuroinflammation

HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

(2017) Christian Eggers et al.   JOURNAL OF NEUROLOGY

Mechanisms of CNS Viral Seeding by HIV + CD14 + CD16 + Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders

(2017) Mike Veenstra et al.   mBio

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

(2016) Shamsudheen Moidunny et al.   Journal of Neuroinflammation

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

The role of chemokine C-C motif ligand 2 genotype and cerebrospinal fluid chemokine C-C motif ligand 2 in neurocognition among HIV-infected patients

(2015) April D. Thames et al.   AIDS

Pioglitazone for Hepatic Steatosis in HIV/Hepatitis C Virus Coinfection

(2015) Lindsay Matthews et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease

(2015) Kai Lun Chang et al.   Scientific Reports

The Relationship of CSF and Plasma Cytokine Levels in HIV Infected Patients with Neurocognitive Impairment

(2015) Lin Yuan et al.   Biomed Research International

PPAR Agonist-Mediated Protection against HIV Tat-Induced Cerebrovascular Toxicity is Enhanced in MMP-9-Deficient Mice

(2014) Wen Huang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of anti-inflammatory compounds in human immunodeficiency virus-1 glycoprotein120-mediated brain inflammation

(2014) Tamima Ashraf et al.   Journal of Neuroinflammation

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

A Concise Panel of Biomarkers Identifies Neurocognitive Functioning Changes in HIV-Infected Individuals

(2013) Thomas D. Marcotte et al.   Journal of Neuroimmune Pharmacology

Enhanced Human Immunodeficiency Virus Type 1 Expression and Neuropathogenesis in Knockout Mice Lacking Type I Interferon Responses

(2013) Hongxia He et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cytokines in CSF correlate with HIV-associated neurocognitive disorders in the post-HAART era in China

(2013) Lin Yuan et al.   JOURNAL OF NEUROVIROLOGY

Mechanisms of HIV Entry into the CNS: Increased Sensitivity of HIV Infected CD14+CD16+ Monocytes to CCL2 and Key Roles of CCR2, JAM-A, and ALCAM in Diapedesis

(2013) Dionna W. Williams et al.   PLoS One

Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies Peroxisome Proliferator-Activated Receptor Gamma as an intrinsic negative regulator of viral replication

(2013) Annie Bernier et al.   Retrovirology

Roles and functions of HIV-1 Tat protein in the CNS: an overview

(2013) Asen Bagashev et al.   Virology Journal

Isolation and Culture of Mouse Cortical Astrocytes

(2013) Sebastian Schildge et al.   Jove-Journal of Visualized Experiments

Low Cerebrospinal Fluid Concentrations of the Nucleotide HIV Reverse Transcriptase Inhibitor, Tenofovir

(2012) Brookie M. Best et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Critical Role for Antiapoptotic Bcl-xL and Mcl-1 in Human Macrophage Survival and Cellular IAP1/2 (cIAP1/2) in Resistance to HIV-Vpr-induced Apoptosis

(2012) Aurelia Busca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells

(2012) Debjani Guha et al.   Journal of Neuroinflammation

PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling

(2011) Wen Huang et al.   FASEB JOURNAL

Mice Chronically Infected with Chimeric HIV Resist Peripheral and Brain Superinfection: A Model of Protective Immunity to HIV

(2011) Jennifer L. Kelschenbach et al.   Journal of Neuroimmune Pharmacology

Regulation of P-glycoprotein by human immunodeficiency virus-1 in primary cultures of human fetal astrocytes

(2011) Tamima Ashraf et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Meta-Analysis of Six Placebo-Controlled Trials of Thiazolidinedione Therapy for HIV Lipoatrophy

(2010) Janet M. Raboud et al.   HIV CLINICAL TRIALS

Implications of Efavirenz for Neuropsychiatry: A Review

(2010) G. I. T. Cavalcante et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities

(2010) Kathryn A. Lindl et al.   Journal of Neuroimmune Pharmacology

Neurologic disease burden in treated HIV/AIDS predicts survival: A population-based study

(2010) P. Vivithanaporn et al.   NEUROLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage

(2010) Valentin Le Douce et al.   Retrovirology

PPARγ and LXR Signaling Inhibit Dendritic Cell-Mediated HIV-1 Capture and trans-Infection

(2010) Timothy M. Hanley et al.   PLoS Pathogens

Peroxisome proliferator-activated receptor-γ activation suppresses HIV-1 replication in an animal model of encephalitis

(2009) Raghava Potula et al.   AIDS

PPARα and PPARγ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

(2009) Wen Huang et al.   FASEB JOURNAL

HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells

(2008) Patrick T. Ronaldson et al.   JOURNAL OF NEUROCHEMISTRY

PPARα and PPARγ effectively protect against HIV-induced inflammatory responses in brain endothelial cells

(2008) Wen Huang et al.   JOURNAL OF NEUROCHEMISTRY

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Regulation of Glial Cell Functions by PPAR- Natural and Synthetic Agonists

(2008) Antonietta Bernardo et al.   PPAR Research

Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists

(2007) Ramya Kapadia   Frontiers in Bioscience-Landmark