An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs

Sequence Symmetry Analysis as a Signal Detection Tool for Potential Heart Failure Adverse Events in an Administrative Claims Database

(2016) Izyan A. Wahab et al.   DRUG SAFETY

Association between Benzodiazepine Use and Dementia: Data Mining of Different Medical Databases

(2016) Mitsutaka Takada et al.   International Journal of Medical Sciences

Inverse Association between Sodium Channel-Blocking Antiepileptic Drug Use and Cancer: Data Mining of Spontaneous Reporting and Claims Databases

(2016) Mitsutaka Takada et al.   International Journal of Medical Sciences

Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events

(2016) Kejian Wang et al.   JOURNAL OF MEDICAL INTERNET RESEARCH

Can you teach old drugs new tricks?

(2016) Nicola Nosengo   NATURE

In silico methods for drug repurposing and pharmacology

(2016) Rachel A. Hodos et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Integrative transcriptomic meta-analysis of Parkinson’s disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson’s disease

(2016) Jose A. Santiago et al.   Scientific Reports

Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism

(2016) Takuya Nagashima et al.   Scientific Reports

OpenVigil FDA – Inspection of U.S. American Adverse Drug Events Pharmacovigilance Data and Novel Clinical Applications

(2016) Ruwen Böhm et al.   PLoS One

A survey of current trends in computational drug repositioning

(2015) Jiao Li et al.   BRIEFINGS IN BIOINFORMATICS

Computational and Experimental Advances in Drug Repositioning for Accelerated Therapeutic Stratification

(2015) Khader Shameer et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database

(2015) Mai Fujimoto et al.   International Journal of Medical Sciences

Association of Statin Use with Sleep Disturbances: Data Mining of a Spontaneous Reporting Database and a Prescription Database

(2014) Mitsutaka Takada et al.   DRUG SAFETY

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Connections in pharmacology: innovation serving translational medicine

(2013) Trinidad Montero-Melendez et al.   DRUG DISCOVERY TODAY

Data Mining of the Public Version of the FDA Adverse Event Reporting System

(2013) Toshiyuki Sakaeda et al.   International Journal of Medical Sciences

The validity of sequence symmetry analysis (SSA) for adverse drug reaction signal detection

(2013) Izyan A. Wahab et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Systems Pharmacology of Adverse Event Mitigation by Drug Combinations

(2013) S. Zhao et al.   Science Translational Medicine

Applications of Connectivity Map in drug discovery and development

(2012) Xiaoyan A. Qu et al.   DRUG DISCOVERY TODAY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

Parthenolide, an inhibitor of the nuclear factor-κB pathway, ameliorates dextran sulfate sodium-induced colitis in mice

(2011) Zhi Jing Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Systematic Drug Repositioning Based on Clinical Side-Effects

(2011) Lun Yang et al.   PLoS One

The Emergence of Genome-Based Drug Repositioning

(2011) Y. A. Lussier et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

NF-κB in the regulation of epithelial homeostasis and inflammation

(2010) Andy Wullaert et al.   CELL RESEARCH

Development of a Database of Health Insurance Claims: Standardization of Disease Classifications and Anonymous Record Linkage

(2010) Shinya Kimura et al.   JOURNAL OF EPIDEMIOLOGY

Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data

(2010) Ilya Kupershmidt et al.   PLoS One

Adverse events with use of antiepileptic drugs: a prescription and event symmetry analysis

(2009) Ioannis Tsiropoulos et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY