Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

Network-based prediction of drug–target interactions using an arbitrary-order proximity embedded deep forest

(2020) Xiangxiang Zeng et al.   BIOINFORMATICS

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Coronavirus Infections—More Than Just the Common Cold

(2020) Catharine I. Paules et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

(2019) Shuofeng Yuan et al.   Nature Communications

Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

(2019) Philip V'kovski et al.   eLife

Network-based prediction of drug combinations

(2019) Feixiong Cheng et al.   Nature Communications

Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer

(2019) Iris Nira Smith et al.   AMERICAN JOURNAL OF HUMAN GENETICS

deepDR: A network-based deep learning approach to in silico drug repositioning

(2019) Xiangxiang Zeng et al.   BIOINFORMATICS

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

A Structure-Informed Atlas of Human-Virus Interactions

(2019) Gorka Lasso et al.   CELL

A genome-wide positioning systems network algorithm for in silico drug repurposing

(2019) Feixiong Cheng et al.   Nature Communications

Computational network biology: Data, models, and applications

(2019) Chuang Liu et al.   PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

(2018) Christin Müller et al.   ANTIVIRAL RESEARCH

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells

(2018) Yu Cong et al.   PLoS One

CRISPR–Cas9 Genetic Analysis of Virus–Host Interactions

(2018) Makda Gebre et al.   Viruses-Basel

Network-based approach to prediction and population-based validation of in silico drug repurposing

(2018) Feixiong Cheng et al.   Nature Communications

Putting the Patient Back Together — Social Medicine, Network Medicine, and the Limits of Reductionism

(2017) Jeremy A. Greene et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Evolution of Human Coronavirus Genomes

(2017) Diego Forni et al.   TRENDS IN MICROBIOLOGY

Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun

(2017) To Sing Fung et al.   Cell Death & Disease

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

(2016) Nicholas J. Barrows et al.   Cell Host & Microbe

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

(2016) Yuguang Zhao et al.   NATURE

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Pleiotropic effects of statins: new therapeutic targets in drug design

(2016) Onkar Bedi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Drug Repurposing: New Treatments for Zika Virus Infection?

(2016) Feixiong Cheng et al.   TRENDS IN MOLECULAR MEDICINE

Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis

(2016) Feixiong Cheng et al.   PLoS Computational Biology

Irbesartan, an FDA approved drug for hypertension and diabetic nephropathy, is a potent inhibitor for hepatitis B virus entry by disturbing Na+-dependent taurocholate cotransporting polypeptide activity

(2015) Xue-jun Wang et al.   ANTIVIRAL RESEARCH

Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus

(2015) Kai-Wen Cheng et al.   ANTIVIRAL RESEARCH

The FDA approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide

(2015) Chunkyu Ko et al.   ANTIVIRAL THERAPY

Host cell mTORC1 is required for HCV RNA replication

(2015) Stefanie Stöhr et al.   GUT

The $2.6 Billion Pill — Methodologic and Policy Considerations

(2015) Jerry Avorn   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information

(2015) Hong Yang et al.   NUCLEIC ACIDS RESEARCH

Database resources of the National Center for Biotechnology Information

(2015)   NUCLEIC ACIDS RESEARCH

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection

(2015) Shanshan He et al.   Science Translational Medicine

Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

(2014) Adriaan H. de Wilde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis

(2014) Jason Kindrachuk et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection

(2014) Julie Dyall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ebola virus disease: potential use of melatonin as a treatment

(2014) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

Integrative Functional Genomics of Hepatitis C Virus Infection Identifies Host Dependencies in Complete Viral Replication Cycle

(2014) Qisheng Li et al.   PLoS Pathogens

Adjuvant Treatment With a Mammalian Target of Rapamycin Inhibitor, Sirolimus, and Steroids Improves Outcomes in Patients With Severe H1N1 Pneumonia and Acute Respiratory Failure*

(2013) Chun-Hua Wang et al.   CRITICAL CARE MEDICINE

The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology

(2013) E. Emmott et al.   JOURNAL OF VIROLOGY

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Transient Oligomerization of the SARS-CoV N Protein – Implication for Virus Ribonucleoprotein Packaging

(2013) Chung-ke Chang et al.   PLoS One

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

(2013) L. M. Johansen et al.   Science Translational Medicine

Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus

(2013) L. Josset et al.   mBio

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Host mTORC1 Signaling Regulates Andes Virus Replication

(2012) S. McNulty et al.   JOURNAL OF VIROLOGY

Systematic identification of synergistic drug pairs targeting HIV

(2012) Xu Tan et al.   NATURE BIOTECHNOLOGY

Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

(2012) Feixiong Cheng et al.   PLoS Computational Biology

Emodin inhibits current through SARS-associated coronavirus 3a protein

(2011) Silvia Schwarz et al.   ANTIVIRAL RESEARCH

Toremifene is an effective and safe alternative to tamoxifen in adjuvant endocrine therapy for breast cancer: results of four randomized trials

(2011) Wen-Bin Zhou et al.   BREAST CANCER RESEARCH AND TREATMENT

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Anti-inflammatory effects of eplerenone on viral myocarditis

(2009) Jie Xiao et al.   EUROPEAN JOURNAL OF HEART FAILURE

Identification of a Novel Transcriptional Repressor (HEPIS) That Interacts with nsp-10 of SARS Coronavirus

(2008) Min Hong et al.   VIRAL IMMUNOLOGY