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Oncology
Haruko Hayasaka, Junichi Yoshida, Yasutaka Kuroda, Akihiro Nishiguchi, Michiya Matsusaki, Kei Kishimoto, Hitoshi Nishimura, Mari Okada, Yuki Shimomura, Daichi Kobayashi, Yoshihito Shimazu, Yuji Taya, Mitsuru Akashi, Masayuki Miyasaka
Summary: Chemokines play a crucial role in breast cancer metastasis to lymph nodes, with the CXCL12/CXCR4 signaling pathway promoting breast cancer cell migration towards CCR7 ligand-expressing intratumoral lymphatic vessels.
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Immunology
Ornella Patrizi, Manuela Baronio, Luisa Gazzurelli, Stefano Rossi, Sara Rezzola, Emanuela Marcenaro, Alessandro Plebani, Raffaele Badolato, Silvia Parolini, Vassilios Lougaris, Giovanna Tabellini
Summary: DOCK8 deficiency affects the function and expression of NK cells, leading to decreased response to viral infections and impaired migration to lymph nodes.
CLINICAL IMMUNOLOGY
(2022)
Article
Neurosciences
Jiapei Huang, Lan Yi, Xiaoxiao Yang, Qi Zheng, Jun Zhong, Sen Ye, Xican Li, Hui Li, Dongfeng Chen, Caixia Li
Summary: The transplantation of NSCs combined with ethyl stearate can improve the motor behavioral performance of PD rats by promoting NSCs migration and differentiation into dopaminergic neurons through CCL5/CCR5 signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
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Biotechnology & Applied Microbiology
Ming Lei, Kangcheng Zhao, Wenbin Hua, Kun Wang, Shuai Li, Xinghuo Wu, Cao Yang
Summary: The study demonstrated that overexpression of c-Jun has a positive effect on the treatment of intervertebral disc degeneration, inhibiting the inflammatory response in vivo and potentially delaying the degeneration of the intervertebral disc.
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Dermatology
Kenta Nakamura, Atsuko Ashida, Yukiko Kiniwa, Ryuhei Okuyama
Summary: This study found that CCL5 and CXCL12 in blood may serve as biomarkers to predict the therapeutic effect of anti-PD-1 therapy in patients with advanced malignant melanoma. Patients with lower levels of CCL5 and CXCL12 had more TILs and better disease-specific survival rates, indicating these chemokines could be useful predictors for treatment outcomes.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Rheumatology
Eun Jeong Won, Hui-Ju Kim, Yu Jeong Lee, Moon-Ju Kim, Hae-In Lee, Hyun Hee Jang, Seong Hoon Kim, Ji-Hyoun Kang, Ki-Jeong Park, Seung Cheol Shim, Sungsin Jo, Tae-Hwan Kim, Tae-Jong Kim
Summary: This study aims to examine the effectiveness of CCL20 inhibition in treating inflammation in AS. The results show that CCL20 affects the migration of Th17 cells and that the CCL20 inhibitor can reduce joint inflammation in AS patients. Therefore, targeting CCL20 inhibition could be a novel therapeutic approach for AS treatment.
Article
Medicine, Research & Experimental
Xiaoqian Shang, Liang Wang, Yumei Liu, Xuemei Liu, Jie Lv, Xuan Zhou, Hao Wang, Shaxika Nazierhan, Jing Wang, Xiumin Ma
Summary: The study investigated the role of CXCR3 and its ligands in diagnosing spinal tuberculosis (ST), finding that IFN-gamma, CXCR3, and CXCL10 were significantly elevated in ST patients, serving as more reliable diagnostic markers.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Physiology
QiFeng Liu, ShaSha Li, LiXia Yu, XiaoYa Yin, Xi Liu, JianMing Ye, GuoYuan Lu
Summary: This study investigates the role of the CCL5/p-STAT3/DNMT1 axis in the epigenetic regulation of Klotho expression in chronic kidney disease (CKD). The findings suggest potential therapeutic possibilities for reversing Klotho suppression in CKD.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuchang Zhou, Rui Niu, Han Sun, Sung-Hak Kim, Xiong Jin, Jinlong Yin
Summary: This study identifies MAP3K1 as a regulator of GSC invasion and tumor progression through activation of the c-JUN signaling pathway, highlighting it as a potential therapeutic target for infiltrative GBM.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Nathan Vanalken, Katrijn Boon, Jordi Doijen, Dominique Schols, Tom Van Loy
Summary: This study evaluated an alternative method, cellular electrical impedance (CEI), to analyze CCR7 signaling. The results showed that CCR7 interactions with CCL19 and CCL21 induced different impedance responses, mainly due to differential beta-arrestin recruitment. G alpha i-mediated signaling contributed the most to the impedance profile, with involvement of G alpha q and G alpha 12/13 pathways as well.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hongyan Hu, Yi Zhang, Liufang Zhao, Wentao Zhao, Xiaoxiong Wang, En Ye, Yan Dong, Lijuan Zhang, Fengming Ran, Yongchun Zhou, Yunchao Huang
Summary: The study revealed that the expression of AFF4 was upregulated in melanoma, closely related to patient prognosis, and could promote invasion and migration of melanoma cells by mediating EMT, potentially regulating c-Jun activity to drive melanoma tumorigenesis.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Siling Fu, Yanxiao Wang, Ennan Bin, Huanwei Huang, Fengchao Wang, Nan Tang
Summary: We used single-cell RNA sequencing to analyze the molecular features of lymphatic endothelial cells (LECs) in embryonic and postnatal day (P) 0 lungs. We found that c-JUN expression is transiently upregulated in P0 LECs. Conditional knockout of Jun in LECs impairs the opening of lung lymphatic vessels at birth, leading to fluid retention in the lungs and neonatal death. Mechanical pressure induces the expression of c-JUN in LECs, and c-JUN regulates the opening of lymphatic vessels by modulating the remodeling of the actin cytoskeleton in LECs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Jia He, Yue Du, Gaopeng Li, Peng Xiao, Xingzheng Sun, Wenjun Song, Lihua Lai, Meng Xia, Jianhua Zhang, Qingqing Wang
Summary: The decreased expression of Fbxw7 is significantly related to the severity of pulmonary fibrosis in IPF patients. Fbxw7 is a key inhibitory factor for the development and progression of pulmonary fibrosis. Fbxw7 suppresses the expression of TGF-beta in profibrotic macrophages by interacting with and degrading C-Jun.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Weiwei Yu, Ting Ye, Jie Ding, Yi Huang, Yang Peng, Qin Xia, Zhang Cuntai
Summary: The study found that the expression of CCL3 is increased in COPD, causing damage to TJs through CCR5, while miR-4456 can suppress the effect of CCL3 on TJs by binding to the 3'-UTR of CCL3, suggesting that the miR-4456/CCL3/CCR5 pathway could be a potential target for COPD treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yeonhee Lee, Jangwook Lee, Minkyoung Park, Areum Seo, Kyu Hyeon Kim, Seonmi Kim, Minjung Kang, Eunjeong Kang, Kyung Don Yoo, Sunhwa Lee, Dong Ki Kim, Kook-Hwan Oh, Yon Su Kim, Kwon Wook Joo, Seung Hee Yang
Summary: We investigated the levels of chemokine CCL8 in PD effluent and serum, as well as its tissue expression, and found an association with peritoneal fibrosis. We also found that CCL8 levels significantly increased with the duration of PD and were correlated with peritoneal transport parameters. In a mouse model, CCL8 blockade improved peritoneal inflammation and fibrosis.
Article
Medicine, Research & Experimental
Chung-Liang Li, Cheng-Che Wu, Jung-Yu Kan, Fang-Ming Chen, Ming-Feng Hou, Chieh-Han Chuang, Hsin- Huang, Fu Ou-Yang
Summary: This study examined the effectiveness of neoadjuvant chemotherapy in breast cancer patients of different age groups and found that elder patients had better survival outcomes after achieving pathological complete response (pCR), while younger patients had higher disease-free survival rates in non-pCR patients.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Correction
Health Care Sciences & Services
Chieh-Ni Kao, Sin-Hua Moi, Ming-Feng Hou, Chi-Wen Luo, Fang-Ming Chen, Mei-Ren Pan
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Chia-Hung Yen, Ming-Feng Hou, Yuan-Bin Cheng, Chih-Wen Shu, Hsueh-Wei Chang
Summary: The study demonstrates that PHA can induce autophagy in breast cancer cells, and autophagy inhibitors can enhance the cytotoxic effects of PHA. Furthermore, PHA increases ROS levels, while ROS scavenger NAC decreases PHA-induced autophagy activity. Autophagy inhibitors also enhance PHA-induced apoptosis, while NAC blocks apoptosis. This suggests that autophagy induced by PHA plays an antioxidant and anti-apoptotic role in breast cancer cells.
Review
Biochemistry & Molecular Biology
Meng-Chien Willie Hsieh, Wei-Ting Wang, Jwu-Lai Yeh, Chuang-Yu Lin, Yur-Ren Kuo, Su-Shin Lee, Ming-Feng Hou, Yi-Chia Wu
Summary: Pulmonary arterial hypertension (PAH) is a serious progressive disorder that currently has no cure. The existing pharmacological agents for PAH are limited in their ability to reverse disease progression. This review explores potential therapeutic targets and strategies for treating PAH.
Article
Biochemistry & Molecular Biology
Chung-Liang Li, Sin-Hua Moi, Huei-Shan Lin, Ming-Feng Hou, Fang-Ming Chen, Shen-Liang Shih, Jung-Yu Kan, Chieh-Ni Kao, Yi-Chia Wu, Li-Chun Kao, Ying-Hsuan Chen, Yi-Chen Lee, Chih-Po Chiang
Summary: This study identifies candidate gene sets that play critical roles in the resistance of endocrine therapy for hormone-receptor-positive breast cancer. These gene sets can differentiate different treatment response groups and are significantly correlated with survival outcomes. This has important clinical implications for the diagnosis, mechanism, and therapeutic strategy in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jen-Yang Tang, Ya-Ting Chuang, Jun-Ping Shiau, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: AKT serine-threonine kinase and its effectors play essential roles in maintaining various cellular functions of cancer cells, while lncRNAs and circRNAs regulate the expression of these functions through multiple pathways. This review provides comprehensive information about the relationship between lncRNAs, circRNAs, and AKT in the regulation of cancer cell functions.
Article
Biochemistry & Molecular Biology
Ya-Ting Chuang, Jun-Ping Shiau, Ching-Yu Yen, Ming-Feng Hou, Jiiang-Huei Jeng, Jen-Yang Tang, Hsueh-Wei Chang
Summary: Combined treatment is a promising strategy for cancer therapy, but it may have adverse effects on normal cells. This study found that fucoidan (FN), a safe food ingredient derived from brown algae, has preferential antiproliferation effects on oral cancer cells. When combined with ultraviolet C (UVC) irradiation, FN effectively reduced the viability of oral cancer cells and induced higher levels of apoptosis, oxidative stress, and DNA damage compared to single treatments. This suggests that UVC/FN treatment has potential for targeted and synergistic antiproliferation in oral cancer therapy.
Article
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Jen-Yang Tang, Shu-Rong Chen, Ming-Feng Hou, Jiiang-Huei Jeng, Yuan-Bin Cheng, Hsueh-Wei Chang
Summary: This study aimed to evaluate the antiproliferative effects of methanol extract of T. swinhoei (METS) on oral cancer cells and compare its detailed responses to normal cells. The results showed that METS effectively inhibited the proliferation of oral cancer cells while not affecting normal cell viability, suggesting a preferential antiproliferative function. METS induced apoptosis, cellular and mitochondrial oxidative stress, and DNA damage in oral cancer cells, which could be reversed by an oxidative stress inhibitor. Additionally, METS activated both extrinsic and intrinsic caspases.
Review
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Jen-Yang Tang, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ching-Yu Yen, Hsueh-Wei Chang
Summary: Oxidative stress and AKT pathway play crucial roles in regulating various cell functions in cancer cells. Natural products have the potential to modulate oxidative stress and AKT for anticancer effects. However, the underlying mechanisms of how they regulate cell functions, particularly the contribution of AKT downstream effectors, are not well understood. This review discusses the roles of oxidative stress and AKT pathway in ten cell functions and highlights the potential of natural products in regulating these functions, with a focus on AKT effectors that have been rarely reported.
Review
Oncology
Ya-Ting Chuang, Jen-Yang Tang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Kun-Han Yang, Ming-Feng Hou, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: Cancer cells produce exosomes to regulate cell functions for tumor progression, and the modulation of exosome processing by natural products is not well understood. This review focuses on the organization of cancer-derived exosomal miRNAs and their processing and cell functions modulation by natural products. It provides a comprehensive understanding of the potential mechanisms and targets for exosome processing and cancer cell functions by natural products.
Article
Biochemistry & Molecular Biology
Chung-Yi Chen, Yan-Ning Chen, Jun-Ping Shiau, Jen-Yang Tang, Ming-Feng Hou, Hsueh-Wei Chang
Summary: This study found that 3HDT has an antiproliferative effect on triple-negative breast cancer cells, while having less impact on normal cells. Through various tests, it was found that 3HDT mainly acts on TNBC cells through oxidative stress and causes DNA damage. Therefore, 3HDT is an effective drug with selective antiproliferative and therapeutic effects on TNBC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Yuan-Bin Cheng, Ming-Feng Hou, Chia-Hung Yen, Hsueh-Wei Chang
Summary: Physapruin A (PHA), a compound extracted from Physalis plants, can induce endoplasmic reticulum stress to regulate proliferation and apoptosis of breast cancer cells, which is associated with oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Ching-Yu Yen, Fang-Rong Chang, Kun-Han Yang, Ming-Feng Hou, Jen-Yang Tang, Hsueh-Wei Chang
Summary: This review aims to elucidate the relationship between natural products, miRNAs, and the AKT pathway in cancer cell development. By identifying the connections between miRNAs and the AKT pathway, as well as miRNAs and natural products, an miRNA/AKT/natural product axis was established to facilitate a better understanding of their anticancer mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Min-Yu Lee, Jun-Ping Shiau, Jen-Yang Tang, Ming-Feng Hou, Phoebe Sussana Primus, Chai-Lin Kao, Yeun-Mun Choo, Hsueh-Wei Chang
Summary: This study found that extracts from the traditional herb Boesenbergia plant in Southern Asia have anticancer effects on triple-negative breast cancer (TNBC) cells, and a new compound called StenB has been isolated. StenB suppresses the proliferation of TNBC cells by modulating oxidative stress and apoptosis signaling pathways, while showing little cytotoxicity to normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)