Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pathology
Yan Wang, Judith A. Mack, Vincent C. Hascall, Edward Maytin
Summary: Deletion of hyaluronan-related genes accelerates skin wound healing, increases TGF-β activity and dermal collagen maturation. α-SMA expression in Has1/3-null fibroblasts is associated with increased phosphorylation of p38 MAPK, and p38 MAPK is involved in the noncanonical TGF-β signaling pathway driving α-SMA expression. Additionally, enhanced binding and nuclear localization of MRTF in Has1/3-null fibroblasts play a critical role in baseline and overexpression of α-SMA. Increased total matrix metalloproteinase activity in healing skin may explain the increased activation of TGF-β.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Casandra Carrillo, Vagisha Ravi, Sarika Tiwari, Ellen A. Chernoff, Teri L. Belecky-Adams
Summary: The factors necessary for cell differentiation in the retina are not fully understood. This study focuses on the potential role of transforming growth factor beta-activated kinase 1 (TAK1) in the differentiation of cell types in the chick retina. The results indicate that TAK1 plays a unique role in differentiating and proliferating retinal cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yuhan Wang, Li Zhao, DuoJun Qiu, Yonghong Shi, Huijun Duan
Summary: This study investigated the role of the TAK1/p38 MAPK/TGF-beta 1 signaling pathway in the oxidative stress and apoptosis of HK-2 cells under high glucose induction. The results showed that high glucose promoted the production of ROS and aggravated oxidative stress, leading to cell apoptosis. Inhibition of TAK1 expression reduced ROS production and oxidative stress, alleviating cell apoptosis.
Review
Medicine, Research & Experimental
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.
Review
Cell Biology
Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Sai Kiang Lim, Carl-Henrik Heldin, Aristidis Moustakas
Summary: This review summarizes the impact of extracellular vesicles (EVs) on the transforming growth factor beta (TGF-beta) signaling pathway in cancer. The cargo of EVs, including various molecules associated with TGF-beta pathway, can influence tumorigenesis, metastatic spread, immune evasion, and response to treatment. Additionally, TGF-beta-related molecules in circulating EVs show potential as useful biomarkers for prognosis, diagnosis, and treatment response in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Xin Yuan, Ling Zhang, Jianlin Du
Summary: It has been shown that Tbx18-positive cells contribute to the development of the urinary system, particularly renal fibroblasts. Under pathological conditions induced by UUO, Tbx18-positive cells may act as profibrotic progenitors, with TGF-beta potentially playing a role in their differentiation into myofibroblasts in kidney fibrosis.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Cell Biology
Ran Zhang, Jingting Lin, Yang Liu, Shurong Yang, Qi He, Liang Zhu, Xiao Yang, Guan Yang
Summary: Proper differentiation of odontoblasts is crucial for the development of tooth roots. Disruption of TGF-beta signaling in root pre-odontoblasts leads to abnormal formation of root osteodentin and ectopic osteogenic differentiation of odontoblasts. Upregulation of Wnt signaling is observed when TGF-beta signaling is disrupted, and inhibiting Wnt signaling can reduce ectopic osteogenic differentiation and halt odontoblast differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Anirban Roy, Ashok Kumar
Summary: The study reveals that supraphysiological activation of TAK1 can promote muscle hypertrophy through the regulation of eIF4E, and prevent denervation-induced muscle atrophy. This finding highlights the important role of TAK1 in skeletal muscle growth and maintenance.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Changfu Liu, Weihao Zhang, Junfeng Wang, Tongguo Si, Wenge Xing
Summary: TAMs promote colorectal cancer progression by inducing glycolytic state, stem-like phenotypes, and invasion through HIF1 alpha/TRIB3-dependent activation of beta-catenin/Wnt signaling pathway. Blocking HIF1 alpha signals may improve chemotherapy outcomes in colorectal cancer treatment.
Article
Pathology
Christina H. Stuelten, Nicolas Melis, Bhagawat Subramanian, Yi Tang, Megan Kimicata, John P. Fisher, Roberto Weigert, Ying E. Zhang
Summary: This study found that Smurf2 plays an important role in cutaneous wound healing. Loss of Smurf2 exacerbates early inflammation in the wounds and leads to narrower wounds but with greater breaking strength. In addition, loss of Smurf2 also increases the linearization of collagen bundles in normal and wounded skin.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanan Min, Long Hao, Xinguang Liu, Shuai Tan, Hui Song, Hao Ni, Zi Sheng, Natalie Jooss, Xuena Liu, Rickard E. Malmstrom, Yang Sun, Jianguo Liu, Hua Tang, Hao Zhang, Chunhong Ma, Jun Peng, Ming Hou, Nailin Li
Summary: This study investigated the mechanisms underlying the regulation of effector responses of naive CD4(+) T (Tn) cells by platelets. The results showed that platelets exert sophisticated regulation on various types of T helper cells and regulatory T cells in a time-, concentration-, and organ-dependent manner, in cooperation with transforming growth factor beta (TGF beta) and platelet factor 4 (PF4). This study highlights the importance of platelet-targeted interventions for T cell immunity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Rheumatology
Fabian A. Mendoza, Sergio A. Jimenez
Summary: Serine/threonine kinases mediate phosphorylation of intracellular protein targets and play a crucial role in regulating cellular functions, including fibrosis development and maintenance in diseases. Drugs targeting and inhibiting these kinases have been developed and may serve as potential therapeutic agents for fibrotic diseases.
Article
Multidisciplinary Sciences
Fei Lu, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu, Mulin Liu
Summary: The study found that CRC patients with high GPC1 expression had poor overall survival, and GPC1 may promote proliferation and migration of CRC cells by influencing the TGF-beta 1 signaling pathway. Additionally, silencing GPC1 inhibited TGF-beta 1 levels and increased SMAD2 expression.
Review
Pharmacology & Pharmacy
Abdul Basit Baba, Bilal Rah, Gh Rasool Bhat, Ifra Mushtaq, Sabra Parveen, Rukhsana Hassan, Mahrukh Hameed Zargar, Dil Afroze
Summary: The ubiquitously expressed cytokine transforming growth factor-beta (TGF-beta) plays a significant role in cellular mechanisms. It functions as a tumor suppressor at the early onset of malignancy but promotes tumorigenesis at an advanced stage. Moreover, TGF-beta regulates cell fate through immune and stroma components.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Ming Li, Shanhu Li, Biao Liu, Meng-Meng Gu, Shitao Zou, Bei-Bei Xiao, Lan Yu, Wei-Qun Ding, Ping-Kun Zhou, Jundong Zhou, Zeng-Fu Shang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2017)
Article
Oncology
Yan Xu, Biao Liu, Fengan Ding, Xiaodie Zhou, Pin Tu, Bo Yu, Yan He, Peilin Huang
Article
Pathology
Biao Liu, Qiu Rao, Yun Zhu, Bo Yu, Hai-yan Zhu, Xiao-jun Zhou
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2012)
Article
Pathology
Xiangshan Fan, Biao Liu, Haodong Xu, Bo Yu, Shanshan Shi, Jin Zhang, Xuan Wang, Jiandong Wang, Zhenfeng Lu, Henghui Ma, Xiaojun Zhou
Article
Oncology
Jiayuan Huang, Haizhu Song, Biao Liu, Bo Yu, Rui Wang, Longbang Chen
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2013)
Article
Oncology
Y. Wan, B. Liu, H. Lei, B. Zhang, Y. Wang, H. Huang, S. Chen, Y. Feng, L. Zhu, Y. Gu, Q. Zhang, H. Ma, S-Y Zheng
ANNALS OF ONCOLOGY
(2018)
Article
Medicine, Research & Experimental
Ming Zhang, Libing Sun, Yi Ru, Shasha Zhang, Junjun Miao, Pengda Guo, Jinghuan Lv, Feng Guo, Biao Liu
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Cell Biology
Weilei Hu, Guosheng Wang, Yundi Chen, Lonny B. Yarmus, Biao Liu, Yuan Wan
Article
Oncology
B. Liu, J. Tan, X. Wang, X. Liu