Targeting the hypoxia-inducible factor (HIF) pathway in cancer

EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1

(2014) Shala L. Thomas et al.   CELL CYCLE

Expression of Hypoxia-Inducible Factor (HIF)-1αand Vascular Endothelial Growth Factor (VEGF)-D As Outcome Predictors in Resected Esophageal Squamous Cell Carcinoma

(2013) Ching Tzao et al.   DISEASE MARKERS

Everolimus (RAD001) and anti-angiogenic cyclophosphamide show long-term control of gastric cancer growth in vivo

(2010) Daniel Cejka et al.   CANCER BIOLOGY & THERAPY

Targeted therapies in metastatic renal cancer in 2009

(2009) Laurence Bastien et al.   BJU INTERNATIONAL

Control of HIF-1  Expression by eIF2  Phosphorylation-Mediated Translational Repression

(2009) K. Zhu et al.   CANCER RESEARCH

Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α

(2009) Woo-Young Kim et al.   CANCER RESEARCH

Marked Activity of Irinotecan and Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the Mammalian Target of Rapamycin/Hypoxia-Inducible Factor-1  Axis

(2009) E. Pencreach et al.   CLINICAL CANCER RESEARCH

Small-Molecule Activation of p53 Blocks Hypoxia-Inducible Factor 1  and Vascular Endothelial Growth Factor Expression In Vivo and Leads to Tumor Cell Apoptosis in Normoxia and Hypoxia

(2009) J. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression of Hypoxia-Inducible Factor-1α, Histone Deacetylase 1, and Metastasis-Associated Protein 1 in Pancreatic Carcinoma

(2009) Kotaro Miyake et al.   PANCREAS

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol inhibits hypoxia-induced metastasis potential enhancement by restricting hypoxia-induced factor-1α expression in colon carcinoma cells

(2008) Hongzhong Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Sunitinib therapy in renal cell carcinoma

(2008) Matthew F. O’Brien et al.   BJU INTERNATIONAL

ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo

(2008) Christian Moser et al.   BMC CANCER

Inhibition of HIF-1α by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo

(2008) H Yasui et al.   BRITISH JOURNAL OF CANCER

Rapid degradation of hypoxia-inducible factor-1α by KRH102053, a new activator of prolyl hydroxylase 2

(2008) H J Choi et al.   BRITISH JOURNAL OF PHARMACOLOGY

HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma

(2008) John D. Gordan et al.   CANCER CELL

A Molecule Targeting VHL-Deficient Renal Cell Carcinoma that Induces Autophagy

(2008) Sandra Turcotte et al.   CANCER CELL

Differential Involvement of Vascular Endothelial Growth Factor in the Survival of Hypoxic Colon Cancer Cells

(2008) M. Calvani et al.   CANCER RESEARCH

TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis

(2008) Lihua Zeng et al.   CANCER SCIENCE

Role of the Phosphatidylinositol-3-Kinase and Extracellular Regulated Kinase Pathways in the Induction of Hypoxia-Inducible Factor (HIF)-1 Activity and the HIF-1 Target Vascular Endothelial Growth Factor in Ovarian Granulosa Cells in Response to Follicle-Stimulating Hormone

(2008) Hena Alam et al.   ENDOCRINOLOGY

Correlation of [18F]FMISO autoradiography and pimonodazole immunohistochemistry in human head and neck carcinoma xenografts

(2008) Esther G. C. Troost et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Inhibition of histone deacetylase down-regulates the expression of hypoxia-induced vascular endothelial growth factor by rheumatoid synovial fibroblasts

(2008) H. Manabe et al.   INFLAMMATION RESEARCH

PX-478, an inhibitor of hypoxia-inducible factor-1α, enhances radiosensitivity of prostate carcinoma cells

(2008) Sanjeewani T. Palayoor et al.   INTERNATIONAL JOURNAL OF CANCER

NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cellsviathe Akt signalling pathway

(2008) Grant D. Stewart et al.   INTERNATIONAL JOURNAL OF CANCER

Prognostic Significance of Tumor Hypoxia Inducible Factor–1α Expression for Outcome After Radiotherapy in Oropharyngeal Cancer

(2008) Priyamal Silva et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Overexpression of hypoxia-inducible factor-1α predicts an unfavorable outcome in urothelial carcinoma of the upper urinary tract

(2008) Hung-Lung Ke et al.   INTERNATIONAL JOURNAL OF UROLOGY

In vivo and in vitro effects of a HIF-1α inhibitor, RX-0047

(2008) Z. Gunnur Dikmen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model

(2008) E.M. Hendriksen et al.   MICROVASCULAR RESEARCH

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 

(2008) M. Y. Koh et al.   MOLECULAR CANCER THERAPEUTICS

A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1 

(2008) S. H. Li et al.   MOLECULAR CANCER THERAPEUTICS

A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth

(2008) L. M. Greenberger et al.   MOLECULAR CANCER THERAPEUTICS

Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198

(2008) Theresa M. LaVallee et al.   MOLECULAR CANCER THERAPEUTICS

Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1  and -2 

(2008) M. Puppo et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells

(2008) Salida Mirzoeva et al.   MOLECULAR CARCINOGENESIS

Inhibition of Siah ubiquitin ligase function

(2008) A Möller et al.   ONCOGENE

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

(2008) E B Rankin et al.   ONCOGENE

Silibinin inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy

(2008) P García-Maceira et al.   ONCOGENE

Hypoxia-inducible factor 1 alpha in oral squamous cell carcinoma and its relation to prognosis

(2008) Masataka Uehara et al.   ORAL ONCOLOGY

Paclitaxel Induces Vascular Endothelial Growth Factor Expression through Reactive Oxygen Species Production

(2008) Hyun Sun Kim et al.   PHARMACOLOGY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen

(2008) A. Bommi-Reddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation

(2008) X. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A23187, ionomycin and thapsigargin upregulate mRNA of HIF-1α via endoplasmic reticulum stress rather than a rise in intracellular calcium

(2007) Christian Werno et al.   JOURNAL OF CELLULAR PHYSIOLOGY