TAK1 regulates endothelial cell necroptosis and tumor metastasis

miRNA-20a upregulates TAK1 and increases proliferation in osteosarcoma cells

(2018) Guangke Yuan et al.   Future Oncology

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

(2018) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-146a promotes gastric cancer cell apoptosis by targeting transforming growth factor β-activated kinase 1

(2017) Yiming Chen et al.   Molecular Medicine Reports

miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma

(2017) Zhenwei Qiu et al.   ONCOLOGY REPORTS

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

(2017) Jiefei Geng et al.   Nature Communications

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

TAK1 regulates Paneth cell integrity partly through blocking necroptosis

(2016) A N Simmons et al.   Cell Death & Disease

TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints

(2016) Xiaoyun Guo et al.   Cell Death & Disease

The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance

(2016) Jérémie Gautheron et al.   Nature Communications

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis

(2015) Mélanie Tichet et al.   Nature Communications

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

TAK1 control of cell death

(2014) S R Mihaly et al.   CELL DEATH AND DIFFERENTIATION

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

(2014) Sho Morioka et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3

(2014) Na Zhao et al.   Molecular Cancer

Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

(2013) Dagmar Schumacher et al.   CANCER CELL

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

(2013) Y Dondelinger et al.   CELL DEATH AND DIFFERENTIATION

G13 Controls Angiogenesis through Regulation of VEGFR-2 Expression

(2013) Kishor Kumar Sivaraj et al.   DEVELOPMENTAL CELL

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration

(2012) S. Morioka et al.   BLOOD

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

(2012) Monika Julia Wolf et al.   CANCER CELL

TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis

(2012) Betty Lamothe et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting of TAK1 in inflammatory disorders and cancer

(2012) Hiroaki Sakurai   TRENDS IN PHARMACOLOGICAL SCIENCES

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

(2011) R.-L. Huang et al.   BLOOD

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Pulmonary Vascular Destabilization in the Premetastatic Phase Facilitates Lung Metastasis

(2009) Y. Huang et al.   CANCER RESEARCH

Anaphylactic shock depends on endothelial Gq/G11

(2009) Hanna Korhonen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effector/Memory but Not Naive Regulatory T Cells Are Responsible for the Loss of Concomitant Tumor Immunity

(2009) Yung-Chang Lin et al.   JOURNAL OF IMMUNOLOGY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

TAK1 Regulates Reactive Oxygen Species and Cell Death in Keratinocytes, Which Is Essential for Skin Integrity

(2008) Emily Omori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL