Pro‐Peptide‐Reinforced, Mucus‐Penetrating Pulmonary siRNA Delivery Mitigates Cytokine Storm in Pneumonia

A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes

(2020) Srinivas Ramishetti et al.   ADVANCED MATERIALS

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Enhanced Transport of Shape and Rigidity-Tuned α-Lactalbumin Nanotubes across Intestinal Mucus and Cellular Barriers

(2020) Cheng Bao et al.   NANO LETTERS

Fluorinated α-Helical Polypeptides Synchronize Mucus Permeation and Cell Penetration toward Highly Efficient Pulmonary siRNA Delivery against Acute Lung Injury

(2020) Chenglong Ge et al.   NANO LETTERS

Charge Conversional Biomimetic Nanocomplexes as a Multifunctional Platform for Boosting Orthotopic Glioblastoma RNAi Therapy

(2020) Yanjie Liu et al.   NANO LETTERS

Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition

(2020) Yi Ju et al.   Advanced Science

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Targeted gene silencing in vivo by platelet membrane–coated metal-organic framework nanoparticles

(2020) Jia Zhuang et al.   Science Advances

Guanidyl and imidazolyl integration group‐modified PAMAM for gastric adenocarcinoma gene therapy

(2020) Dongli Wang et al.   JOURNAL OF GENE MEDICINE

Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma

(2020) Adriana L. da Silva et al.   Science Advances

Efficient Gene Delivery Based on Guanidyl‐Nucleic Acid Molecular Interactions

(2020) Dongli Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Polyamidoamine Dendrimer Grafted with an Acid-Responsive Charge-Reversal Layer for Improved Gene Delivery

(2020) Juan Wang et al.   BIOMACROMOLECULES

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

(2019) Asha Kumari Patel et al.   ADVANCED MATERIALS

Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo

(2019) Dali Wang et al.   Science Advances

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

(2019) Changjun Yin et al.   NATURE MEDICINE

Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection

(2019) Chen Xu et al.   Nature Communications

Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery

(2019) Melissa P. Lokugamage et al.   ADVANCED MATERIALS

Zeta potential changing self-emulsifying drug delivery systems: A promising strategy to sequentially overcome mucus and epithelial barrier

(2019) Imran Nazir et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Enzyme decorated drug carriers: Targeted swords to cleave and overcome the mucus barrier

(2018) Claudia Menzel et al.   ADVANCED DRUG DELIVERY REVIEWS

Size/Charge Changeable Acidity-Responsive Micelleplex for Photodynamic-Improved PD-L1 Immunotherapy with Enhanced Tumor Penetration

(2018) Liangliang Dai et al.   ADVANCED FUNCTIONAL MATERIALS

Unlockable Nanocomplexes with Self-Accelerating Nucleic Acid Release for Effective Staged Gene Therapy of Cardiovascular Diseases

(2018) Jing-Jun Nie et al.   ADVANCED MATERIALS

Production and application of HMGB1 derived recombinant RAGE-antagonist peptide for anti-inflammatory therapy in acute lung injury

(2018) Seonyeong Lee et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells

(2018) Daniel P. Feldmann et al.   JOURNAL OF CONTROLLED RELEASE

A ternary-complex of a suicide gene, a RAGE-binding peptide, and polyethylenimine as a gene delivery system with anti-tumor and anti-angiogenic dual effects in glioblastoma

(2018) Eunji Choi et al.   JOURNAL OF CONTROLLED RELEASE

A modular platform for targeted RNAi therapeutics

(2018) Ranit Kedmi et al.   Nature Nanotechnology

Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide

(2018) Hong-Xia Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles

(2018) Omar F. Khan et al.   Science Advances

Strategies to overcome the polycation dilemma in drug delivery

(2018) Andreas Bernkop-Schnürch   ADVANCED DRUG DELIVERY REVIEWS

Molecular Strings Significantly Improved the Gene Transfection Efficiency of Polycations

(2018) Huapan Fang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanomedicines reveal how PBOV1 promotes hepatocellular carcinoma for effective gene therapy

(2018) Yu Guo et al.   Nature Communications

RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition

(2018) Lauren Rackley et al.   ADVANCED FUNCTIONAL MATERIALS

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

(2018) Qiang Cheng et al.   ADVANCED MATERIALS

Atom Transfer Radical Polymerization of Multishelled Cationic Corona for the Systemic Delivery of siRNA

(2017) Hye Sung Kim et al.   NANO LETTERS

Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy

(2017) Xiaoding Xu et al.   NANO LETTERS

The inflammatory microenvironment and microbiome in prostate cancer development

(2017) Karen S. Sfanos et al.   Nature Reviews Urology

Sub-50 nm Nanoparticles with Biomimetic Surfaces to Sequentially Overcome the Mucosal Diffusion Barrier and the Epithelial Absorption Barrier

(2016) Xi Zhu et al.   ADVANCED FUNCTIONAL MATERIALS

Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted In Vivo siRNA Delivery Vehicles

(2016) Kaylin M. McMahon et al.   ADVANCED FUNCTIONAL MATERIALS

PGMA-Based Star-Like Polycations with Plentiful Hydroxyl Groups Act as Highly Efficient miRNA Delivery Nanovectors for Effective Applications in Heart Diseases

(2016) Rui-Quan Li et al.   ADVANCED MATERIALS

Delivery of the high-mobility group box 1 box A peptide using heparin in the acute lung injury animal models

(2016) Ji Hyun Song et al.   JOURNAL OF CONTROLLED RELEASE

Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells

(2016) Yunfeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overcoming the Diffusion Barrier of Mucus and Absorption Barrier of Epithelium by Self-Assembled Nanoparticles for Oral Delivery of Insulin

(2015) Wei Shan et al.   ACS Nano

Optimizing the Size of Micellar Nanoparticles for Efficient siRNA Delivery

(2015) Shi Liang et al.   ADVANCED FUNCTIONAL MATERIALS

Dual Targeted Immunotherapy via In Vivo Delivery of Biohybrid RNAi-Peptide Nanoparticles to Tumor-Associated Macrophages and Cancer Cells

(2015) João Conde et al.   ADVANCED FUNCTIONAL MATERIALS

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

(2015) Panagiotis Mastorakos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Reduction and pH Dual-Sensitive Polymeric Vector for Long-Circulating and Tumor-Targeted siRNA Delivery

(2014) Jingguo Li et al.   ADVANCED MATERIALS

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Use of Single-Site-Functionalized PEG Dendrons To Prepare Gene Vectors that Penetrate Human Mucus Barriers

(2013) Anthony J. Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles

(2013) Ning Zhang et al.   NATURE MEDICINE

Resolution of acute lung injury and inflammation: a translational mouse model

(2011) Brijesh V. Patel et al.   EUROPEAN RESPIRATORY JOURNAL

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

(2009) B. C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloperoxidase modulates lung epithelial responses to pro-inflammatory agents

(2007) A. Haegens et al.   EUROPEAN RESPIRATORY JOURNAL