LncRNA MEG3 Alleviates Diabetic Cognitive Impairments by Reducing Mitochondrial-Derived Apoptosis through Promotion of FUNDC1-Related Mitophagy via Rac1-ROS Axis

lncRNA H19 prevents endothelial–mesenchymal transition in diabetic retinopathy

(2019) Anu A. Thomas et al.   DIABETOLOGIA

Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus

(2019) Ji-Shi Ye et al.   Oxidative Medicine and Cellular Longevity

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation

(2019) Cheng-Yi Yang et al.   JOURNAL OF NEUROSCIENCE

Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate

(2019) Kaili Ma et al.   CELL DEATH AND DIFFERENTIATION

Upregulation of the lncRNA MEG3 improves cognitive impairment, alleviates neuronal damage, and inhibits activation of astrocytes in hippocampus tissues in Alzheimer's disease through inactivating the PI3K/Akt signaling pathway

(2019) Jiping Yi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A long noncoding RNA LOC103690121 promotes hippocampus neuronal apoptosis in streptozotocin-induced type 1 diabetes

(2019) Lijun Hao et al.   NEUROSCIENCE LETTERS

Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s disease

(2019) Wenjuan Wu et al.   Protein & Cell

Mitochondria in Health and Disease

(2019) Sarah J. Annesley et al.   Cells

TIGAR Attenuates High Glucose-Induced Neuronal Apoptosis via an Autophagy Pathway

(2019) Wenjuan Zhou et al.   Frontiers in Molecular Neuroscience

Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies

(2019) Mei Xue et al.   AGEING RESEARCH REVIEWS

Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA

(2019) Soudeh Ghafouri-Fard et al.   BIOMEDICINE & PHARMACOTHERAPY

NADPH oxidase 2 as a potential therapeutic target for protection against cognitive deficits following systemic inflammation in mice

(2019) Wan-Yu Huang et al.   BRAIN BEHAVIOR AND IMMUNITY

Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis

(2019) Ji Liang et al.   EXPERIMENTAL NEUROLOGY

Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy

(2019) Guangming Fan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission

(2019) Jin Wang et al.   Redox Biology

Recurrent non-severe hypoglycemia exacerbates imbalance of mitochondrial homeostasis leading to synapse injury and cognitive deficit in diabetes

(2018) Yu Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes

(2018) Ying Song et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of Rac1 ameliorates neuronal oxidative stress damage via reducing Bcl-2/Rac1 complex formation in mitochondria through PI3K/Akt/mTOR pathway

(2018) Yundan Pan et al.   EXPERIMENTAL NEUROLOGY

Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin induced reactive oxygen species generation and platelet activation

(2018) H. Akbar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity

(2018) Die Pu et al.   NEUROSCIENCE

The Protective Effect of Astaxanthin on Cognitive Function via Inhibition of Oxidative Stress and Inflammation in the Brains of Chronic T2DM Rats

(2018) Yonghao Feng et al.   Frontiers in Pharmacology

Diabetes-Related Neurological Implications and Pharmacogenomics

(2018) Camilo Andrés Rojas-Carranza et al.   CURRENT PHARMACEUTICAL DESIGN

FUNDC1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation

(2018) Wenhui Li et al.   HEPATOLOGY

LncRNA-MEG3 alleviates high glucose induced inflammation and apoptosis of retina epithelial cells via regulating miR-34a/SIRT1 axis

(2018) Ping Tong et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Blood Glucose Levels May Exacerbate Executive Function Deficits in Older Adults with Cognitive Impairment

(2018) Colleen Pappas et al.   JOURNAL OF ALZHEIMERS DISEASE

Downregulation of long noncoding RNA H19 rescues hippocampal neurons from apoptosis and oxidative stress by inhibiting IGF2 methylation in mice with streptozotocin‐induced diabetes mellitus

(2018) Jin‐Lu Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long non-coding RNA MEG3 regulates proliferation, apoptosis, and autophagy and is associated with prognosis in glioma

(2018) Haikang Zhao et al.   JOURNAL OF NEURO-ONCOLOGY

Long noncoding RNA MEG3 regulates LATS2 by promoting the ubiquitination of EZH2 and inhibits proliferation and invasion in gallbladder cancer

(2018) Longyang Jin et al.   Cell Death & Disease

Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury

(2017) Hao Zhou et al.   Redox Biology

Homocysteine induces mitochondrial dysfunction involving the crosstalk between oxidative stress and mitochondrial pSTAT3 in rat ischemic brain

(2017) Shuang Chen et al.   Scientific Reports

Upregulation of lncRNA MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression

(2016) Xiang Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice

(2016) Li-Li Qiu et al.   BRAIN BEHAVIOR AND IMMUNITY

Studying neuroprotective effect of Atorvastatin as a small molecule drug on high glucose-induced neurotoxicity in undifferentiated PC12 cells: role of NADPH oxidase

(2016) Samira Rayegan et al.   METABOLIC BRAIN DISEASE

High-Glucose-Derived Oxidative Stress-Dependent Heme Oxygenase-1 Expression from Astrocytes Contributes to the Neuronal Apoptosis

(2016) Chuen-Mao Yang et al.   MOLECULAR NEUROBIOLOGY

Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke

(2016) Honglin Yan et al.   NEUROSCIENCE

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

(2016) Weilin Zhang et al.   eLife

Down regulated lncRNA MEG3 eliminates mycobacteria in macrophages via autophagy

(2016) Kamlesh Pawar et al.   Scientific Reports

Personalized medicine in diabetes mellitus: current opportunities and future prospects

(2015) Jeffrey W. Kleinberger et al.   Annals of the New York Academy of Sciences

Modulation of actin dynamics by Rac1 to target cognitive function

(2015) Maria V. Tejada-Simon   JOURNAL OF NEUROCHEMISTRY

Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction

(2015) Qiong Xiang et al.   NEUROPEPTIDES

Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches

(2015) Jianhua Zhang   Redox Biology

Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation

(2014) Juan Liao et al.   NEUROPHARMACOLOGY

Vulnerability for apoptosis in the hippocampal dentate gyrus of STZ-induced diabetic rats with cognitive impairment

(2014) Yi-jing Guo et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins

(2013) S. Cardoso et al.   CURRENT MOLECULAR MEDICINE

Berberine Ameliorate Oxidative Stress and Astrogliosis in the Hippocampus of STZ-Induced Diabetic Rats

(2013) Hamid Kalalian Moghaddam et al.   MOLECULAR NEUROBIOLOGY

Identification of imprinting regulators at the Meg3 differentially methylated region

(2012) Erin N. McMurray et al.   GENOMICS

Diabetes and cognitive dysfunction

(2012) Rory J McCrimmon et al.   LANCET

Cerebrovascular Complications of Diabetes: Focus on Stroke

(2012) Adviye Ergul et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Delayed Administration of Parecoxib, a Specific COX-2 Inhibitor, Attenuated Postischemic Neuronal Apoptosis by Phosphorylation Akt and GSK-3β

(2011) Zhi Ye et al.   NEUROCHEMICAL RESEARCH

A Prenylated p47phox-p67phox-Rac1 Chimera Is a Quintessential NADPH Oxidase Activator

(2010) Ariel Mizrahi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effect of N-acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-treated diabetic rats

(2010) Sukhdev S. Kamboj et al.   MITOCHONDRION

Role of Rac1 GTPase in NADPH Oxidase Activation and Cognitive Impairment Following Cerebral Ischemia in the Rat

(2010) Limor Raz et al.   PLoS One