Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments

(2019) Karen Ruiz et al.   Nature Communications

RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells

(2018) Mark A. Hawk et al.   NATURE CELL BIOLOGY

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

(2018) Ariele Viacava Follis et al.   Nature Chemical Biology

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly

(2017) Apirat Chaikuad et al.   STRUCTURE

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

Apoptosis Inducing Factor Binding Protein PGAM5 Triggers Mitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activity of X-Linked Inhibitor of Apoptosis

(2016) Audrey M. Lenhausen et al.   BIOCHEMISTRY

The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress

(2016) Shiori Sekine et al.   EBioMedicine

The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy

(2014) Hao Wu et al.   Autophagy

A Conserved Motif Mediates both Multimer Formation and Allosteric Activation of Phosphoglycerate Mutase 5

(2014) Jordan M. Wilkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization

(2014) Jingzhen Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL

(2014) Dominic P. Del Re et al.   MOLECULAR CELL

Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder

(2014) Wei Lu et al.   Nature Communications

PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage

(2013) G Arena et al.   CELL DEATH AND DIFFERENTIATION

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Mitochondrial Control of Cellular Life, Stress, and Death

(2012) Lorenzo Galluzzi et al.   CIRCULATION RESEARCH

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints

(2011) Jianfang Wang et al.   CELLULAR SIGNALLING

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila

(2010) Yuzuru Imai et al.   PLoS Genetics

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells

(2009) Fang Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

(2009) D. T. Terrano et al.   MOLECULAR AND CELLULAR BIOLOGY

Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to H2O2-induced Apoptosis

(2008) Chunlai Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY