Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

CRISPR treatment inserted directly into the body for first time

(2020) Heidi Ledford   NATURE

Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

(2020) Rieke Martens et al.   Nature Communications

Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow

(2020) Kelly L. Betterman et al.   JOURNAL OF CLINICAL INVESTIGATION

Update and audit of the St George’s classification algorithm of primary lymphatic anomalies: a clinical and molecular approach to diagnosis

(2020) Kristiana Gordon et al.   JOURNAL OF MEDICAL GENETICS

Phase 1 Lymfactin® Study: Short-term Safety of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema

(2020) Pauliina Hartiala et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis

(2020) Guangxia Wang et al.   Nature Communications

VEGF-C protects the integrity of the bone marrow perivascular niche in mice

(2020) Shentong Fang et al.   BLOOD

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages

(2019) Sang Heon Suh et al.   EMBO REPORTS

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

(2019) Sawan Kumar Jha et al.   eLife

Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC

(2019) Lillian Lim et al.   BLOOD

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

(2019) Adam J. Vogrin et al.   Cell Reports

VEGF-A-Cleavage by FSAP and Inhibition of Neo-Vascularization

(2019) Özgür Uslu et al.   Cells

The evolving role of lymphatics in cancer metastasis

(2018) Rae H Farnsworth et al.   CURRENT OPINION IN IMMUNOLOGY

VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes glioblastoma maintenance

(2018) Signe R Michaelsen et al.   NEURO-ONCOLOGY

Unravelling the mode of action of plant proteases

(2018) Renier A. L. van der Hoorn et al.   NEW PHYTOLOGIST

Plant Viral Proteases: Beyond the Role of Peptide Cutters

(2018) Bernardo Rodamilans et al.   Frontiers in Plant Science

Loss of ADAMTS3 activity causes Hennekam lymphangiectasia–lymphedema syndrome 3

(2017) Pascal Brouillard et al.   HUMAN MOLECULAR GENETICS

Development and plasticity of meningeal lymphatic vessels

(2017) Salli Antila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphedema

(2017) Ayman A. Grada et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database

(2017) Neil D Rawlings et al.   NUCLEIC ACIDS RESEARCH

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

(2017) Manuel Fankhauser et al.   Science Translational Medicine

Targeting therapeutics to endothelium: are we there yet?

(2017) Raisa Yu. Kiseleva et al.   Drug Delivery and Translational Research

RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFAxxxb isoforms

(2017) Stephen Bridgett et al.   Scientific Reports

Mutations in the prostate specific antigen (PSA/KLK3) correlate with male infertility

(2017) Nishi Gupta et al.   Scientific Reports

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

(2017) Sawan Kumar Jha et al.   Scientific Reports

Critical requirement of VEGF-C in transition to fetal erythropoiesis

(2016) S. Fang et al.   BLOOD

Functional Importance of a Proteoglycan Coreceptor in Pathologic LymphangiogenesisNovelty and Significance

(2016) Scott C. Johns et al.   CIRCULATION RESEARCH

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

(2016) Hung M. Bui et al.   JOURNAL OF CLINICAL INVESTIGATION

Applications of Platelet-Rich Plasma in Lymphedema

(2016) Ahmet Akgül et al.   Lymphatic Research and Biology

Comprehensive Proteome Profiling of Platelet Identified a Protein Profile Predictive of Responses to An Antiplatelet Agent Sarpogrelate

(2016) Hangyeore Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Morphological and Molecular Characterization of Human Dermal Lymphatic Collectors

(2016) Viktoria Hasselhof et al.   PLoS One

Applications of Platelet-Rich Plasma in Lymphedema

(2016) Ahmet Akgül et al.   Lymphatic Research and Biology

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis

(2015) Lauriane Janssen et al.   ANGIOGENESIS

VEGF‐C is required for intestinal lymphatic vessel maintenance and lipid absorption

(2015) Harri Nurmi et al.   EMBO Molecular Medicine

A Novel Virus Causes Scale Drop Disease in Lates calcarifer

(2015) Ad de Groof et al.   PLoS Pathogens

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation

(2014) Michael Jeltsch et al.   CIRCULATION

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis

(2014) L. Le Guen et al.   DEVELOPMENT

Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting

(2014) J. W. Astin et al.   DEVELOPMENT

Genetics of lymphatic anomalies

(2014) Pascal Brouillard et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease

(2014) Emilia Balboa-Beltran et al.   JOURNAL OF MEDICAL GENETICS

Mechanism of Dimerization of a Recombinant Mature Vascular Endothelial Growth Factor C

(2013) Joyce Chiu et al.   BIOCHEMISTRY

Mutation in Vascular Endothelial Growth Factor-C, a Ligand for Vascular Endothelial Growth Factor Receptor-3, Is Associated With Autosomal Dominant Milroy-Like Primary Lymphedema

(2013) Kristiana Gordon et al.   CIRCULATION RESEARCH

Extracellular regulation of VEGF: Isoforms, proteolysis, and vascular patterning

(2013) Prakash Vempati et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Proteolytic Processing Regulates Placental Growth Factor Activities

(2013) Daniel C. Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular Endothelial Growth Factor-d Modulates Caliber and Function of Initial Lymphatics in the Dermis

(2013) Sophie Paquet-Fifield et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study

(2013) Louis El Khoury et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

(2013) Silvia Cappello et al.   NATURE GENETICS

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

(2013) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin 47 Mutations Increase Risk for Secondary Lymphedema Following Breast Cancer Treatment

(2012) D. N. Finegold et al.   CLINICAL CANCER RESEARCH

Protease signalling: the cutting edge

(2012) Boris Turk et al.   EMBO JOURNAL

FLT4/VEGFR3and Milroy Disease: Novel Mutations, a Review of Published Variants and Database Update

(2012) Kristiana Gordon et al.   HUMAN MUTATION

Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development

(2012) Joo Facucho-Oliveira et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

(2012) Joanna M Wardlaw et al.   LANCET

Possible Genetic Predisposition to Lymphedema after Breast Cancer

(2012) Beth Newman et al.   Lymphatic Research and Biology

CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo

(2011) Frank L. Bos et al.   CIRCULATION RESEARCH

Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer

(2011) Nicole C. Harris et al.   FASEB JOURNAL

Interaction of tumor cells and lymphatic vessels in cancer progression

(2011) A Alitalo et al.   ONCOGENE

GJC2 Missense Mutations Cause Human Lymphedema

(2010) Robert E. Ferrell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

(2010) V.-M. Leppanen et al.   BLOOD

Kallikreins on Steroids: Structure, Function, and Hormonal Regulation of Prostate-Specific Antigen and the Extended Kallikrein Locus

(2010) Mitchell G. Lawrence et al.   ENDOCRINE REVIEWS

Binding to the Extracellular Matrix and Proteolytic Processing: Two Key Mechanisms Regulating Vascular Endothelial Growth Factor Action

(2010) Napoleone Ferrara   MOLECULAR BIOLOGY OF THE CELL

Structural determinants of growth factor binding and specificity by VEGF receptor 2

(2010) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linkage and sequence analysis indicate that CCBE1 is mutated in recessively inherited generalised lymphatic dysplasia

(2009) Fiona Connell et al.   HUMAN GENETICS

Snake Venom Vascular Endothelial Growth Factors (VEGF-Fs) Exclusively Vary Their Structures and Functions among Species

(2009) Yasuo Yamazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

(2009) Camilla Norrmén et al.   JOURNAL OF CELL BIOLOGY

HGF and MET Mutations in Primary and Secondary Lymphedema

(2009) David N. Finegold et al.   Lymphatic Research and Biology

Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans

(2009) Marielle Alders et al.   NATURE GENETICS

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

(2009) Benjamin M Hogan et al.   NATURE GENETICS

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites

(2009) J. Kunnapuu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of vascular endothelial growth factor on sperm motility and survival

(2009) Ahmet Cem Iyibozkurt et al.   REPRODUCTIVE BIOMEDICINE ONLINE