Article
Multidisciplinary Sciences
Silvia Rigato, Maria Laura Filippetti, Carina de Klerk
Summary: This study investigated infants' expectations about the relative size of infant body parts, and the results showed that infants did not differentiate between typical and proportionally distorted infant body stimuli, and their looking behavior was unrelated to their locomotor skills. These findings suggest that infants may need more visual experience to develop expectations about infant body proportions.
SCIENTIFIC REPORTS
(2023)
Article
Dermatology
Huishan Shi, Jos P. H. Smits, Ellen H. van den Bogaard, Matthew G. Brewer
Summary: The CRISPR/Cas9 technology is a powerful tool used to alter genetic landscapes in various hosts, particularly in developing novel mouse lines modeling disease states. It has been successfully used in both in vitro and in vivo systems within fields like epithelial biology and dermatology. The delivery of single-guide RNA/Cas9 editing complex to host cells is crucial for its success, and different delivery techniques have been explored and evaluated for their benefits and drawbacks in genetically modifying epidermal cells. Recent advances in dermatology have utilized these methods to better understand epidermal biology, identify therapeutic targets, and develop new treatment approaches for disease states.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Microbiology
Travis G. Wentz, Benjamin J. M. Tremblay, Marite Bradshaw, Andrew C. Doxey, Shashi K. Sharma, John-Demian Sauer, Sabine Pellett
Summary: This study used bioinformatic analysis to investigate the CRISPR-Cas systems of 241 strains of C. botulinum and C. sporogenes. The results showed that the CRISPR-Cas systems mainly prevent the transfer of botulinum toxin gene clusters, rather than directly targeting the toxin gene clusters themselves. Additionally, comparative genomics analysis revealed that these genomic features often occupy the same hypervariable loci in both species.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Theodoros P. Vassilakopoulos, Athanasios Liaskas, Patricio Pereyra, Panayiotis Panayiotidis, Maria K. Angelopoulou, Andrea Gallamini
Summary: The long-term survival of HL patients is excellent with current standard of care, including combined-modality schedules and treatment intensity adaptation. However, a significant number of patients still experience primary refractory or relapse. Novel immunotherapeutic agents, such as BV and CPI, have shown outstanding efficacy in relapsed/refractory settings. Adding these agents in frontline treatment may further improve disease control and reduce the need for cytotoxic drugs. The results of ongoing phase 3 trials incorporating anti-PD-1 in this setting will provide more insights.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agricultural Engineering
Liang Zhang, Ling Jiang, Jiangtao Zhang, Jialin Li, Yongzhen Peng
Summary: Anaerobic ammonium oxidation (anammox) has great potential for nitrogen removal from mainstream wastewater. However, there are limitations to its direct application. This review summarizes the technical development of partial anammox and the mechanisms of achieving partial mainstream anammox through aeration and organic control.
BIORESOURCE TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Melanie Koehler, Simon J. L. Petitjean, Jinsung Yang, Pavithra Aravamudhan, Xayathed Somoulay, Cristina Lo Giudice, Megane A. Poncin, Andra C. Dumitru, Terence S. Dermody, David Alsteens
Summary: This study demonstrates a direct interaction between reovirus and beta 1 integrins through viral capsid protein lambda 2, facilitating clathrin recruitment to cell-bound reovirus. Lambda 2 acts as the integrin ligand, promoting reovirus endocytosis reliant on junctional adhesion molecule A (JAM-A) and beta 1 integrin binding.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Han Liu, Jingyue Xu, Yu Lan, Hee-Woong Lim, Rulang Jiang
Summary: This study investigated the molecular mechanisms of tendon development by generating a Scx(Flag) knockin mouse strain and identifying Scx direct target genes in developing tendon tissues. The results provide novel insights into the role of Scx in tendon development and homeostasis, offering valuable resources for further research on tendon cell differentiation and tissue regeneration. The Scx(Flag) mice present a useful tool for unraveling the molecular mechanisms underlying developmental and disease processes involving Scx.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Balakrishnan Navina, Kulakkunnath Keshav Huthaash, Nandha Kumar Velmurugan, Tarangini Korumilli
Summary: This article provides an overview of the problems caused by enzymatic browning in the fruit and vegetable industry and discusses strategies to combat it. It emphasizes the importance of technological innovation and integrated approaches.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Review
Cell Biology
Silja Hansen, Michelle E. McClements, Thomas J. Corydon, Robert E. MacLaren
Summary: Inherited retinal diseases (IRD) are a group of clinically and genetically diverse diseases that cause blindness in the working-age population. Gene augmentation therapies have limitations in treating IRDs, but DNA editing, particularly prime editing, shows potential in correcting different types of mutations. This review provides an overview of recent advancements in prime editing technology and discusses its potential as a treatment option for IRDs.
Article
Biochemistry & Molecular Biology
Dongmei Tang, Huijuan Li, Chengyong Wu, Tingting Jia, Haihuai He, Shaohua Yao, Yamei Yu, Qiang Chen
Summary: This study revealed a distinct structure of the Cas1-Cas2 complex in Pyrococcus furiosus, showing a unique binding mode for pre-spacers. The structural and mutagenesis results led to a model confirming the pre-spacer preference and providing a potential explanation for longer spacer acquisition in P. furiosus. The research showcases the diversity of the CRISPR adaptation module.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Electrical & Electronic
Haodong Zhang, Penglei Zhang, Yahui Li, Rui Zheng, Guifu Ding, Qijun Xiao, Kaiming Su, Shankai Yin, Zhuoqing Yang
Summary: The wearable flexible sensor proposed for sleep respiratory monitoring has demonstrated great performance in measuring respiratory signals, showing clear differences between normal and abnormal breathing patterns. This sensor has shown potential for preliminary diagnosis of sleep respiratory diseases and sleep health monitoring.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2021)
Article
Immunology
Anna Kopf, Boyke Bunk, Sina M. Coldewey, Florian Gunzer, Thomas Riedel, Percy Schrottner
Summary: Recent studies have highlighted the potential for Wohlfahrtiimonas chitiniclastica as a human pathogen causing various diseases. However, there is limited knowledge about its pathogenicity and genetic potential. This study analyzed the entire genetic repertoire of publicly available W. chitiniclastica genomes, revealing potential metabolic conservation and expansion of antibiotic resistance genes. These findings provide new insights into the genome of this opportunistic human pathogen.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Noemi M. Guzman, Belen Esquerra-Ruvira, Francisco J. M. Mojica
Summary: CRISPR-Cas systems are acknowledged as playing various roles in bacteria and archaea, especially in providing protection against transmissible genetic elements. This review summarises the current knowledge on the diversity, molecular mechanisms, and biology of CRISPR-Cas systems, with a focus on recent findings related to their activity.
INTERNATIONAL MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Wei Zhang, Ibrahim Oraiqat, Dale Litzenberg, Kai-Wei Chang, Scott Hadley, Noora Ba Sunbul, Martha M. Matuszak, Christopher J. Tichacek, Eduardo G. Moros, Paul L. Carson, Kyle C. Cuneo, Xueding Wang, Issam El Naqa
Summary: Ionizing radiation acoustic imaging (iRAI) enables real-time monitoring and adaptive feedback for cancer treatments by visualizing the interaction between radiation and tissues. A volumetric imaging system using a 2D matrix array transducer and a multi-channel preamplifier board was developed to map the 3D radiation dose distribution in complex clinical radiotherapy. The feasibility of temporal 3D dose accumulation and semiquantitative iRAI dose measurements were validated in tissue-mimicking phantom and in vivo rabbit model, respectively. Real-time visualization of 3D radiation dose delivered to a patient with liver metastases was achieved using a clinical linear accelerator, demonstrating the potential of iRAI in improving radiotherapy treatment efficacy.
NATURE BIOTECHNOLOGY
(2023)
Article
Health Care Sciences & Services
Kara Dempster, Annie Li, Priyadharshini Sabesan, Ross Norman, Lena Palaniyappan
Summary: The study examined how using a <50% improvement threshold for total symptoms in first episode schizophrenia patients could best predict global functioning over a period of 5 years.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
