Article
Oncology
Yves Boucher, Ashwin S. Kumar, Jessica M. Posada, Evisa Gjini, Kathleen Pfaff, Mikel Lipschitz, Ana Lako, Dan G. Duda, Scott J. Rodig, F. Stephen Hodi, Rakesh K. Jain
Summary: The study showed that a single dose of bevacizumab can reduce the density of angiopoietin-2-positive vessels and increase the infiltration of immune cells in patients with primary triple-negative breast cancer, suggesting a potential rationale for combining bevacizumab with immune checkpoint blockers in neoadjuvant treatment to improve efficacy.
NPJ PRECISION ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Pharmacology & Pharmacy
Aya Yamamura, Md Junayed Nayeem, Hiroyuki Muramatsu, Kogenta Nakamura, Motohiko Sato
Summary: The study revealed that the VEGFR-3 signaling pathway plays a crucial role in the proliferation, migration, and tumor growth of androgen-independent/highly metastatic prostate cancer cells, highlighting its potential as a novel therapeutic target for prostate cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Article
Clinical Neurology
Kai-Feng Shen, Qing-Tian Duan, Wei Duan, Sen-Lin Xu, Ning An, Yan-Yan Ke, Li-Ting Wang, Shi-Yong Liu, Hui Yang, Chun-Qing Zhang
Summary: Increased expression of VEGF-C and its receptors is observed in cortical lesions of FCD patients, and it is involved in modulating NMDA receptor-mediated currents.
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Yolanda Fernandez-Cladera, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Agustin F. Gonzalez-Rivero, Antonia De Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between VEGF and sVEGFR with SLE disease-related features and found that serum levels of VEGF and sVEGFR in SLE patients were associated with disease damage, with musculoskeletal manifestations being the most commonly associated feature.
Article
Pharmacology & Pharmacy
Jun-Hei Chang, Chen-Chuan Cheng, Yen-Yu Lu, Cheng-Chih Chung, Yung-Hsin Yeh, Yao-Chang Chen, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen
Summary: VEGF reduces PV arrhythmogenesis by modulating sodium/calcium homeostasis through VEGFR-1/NOS signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Deepti Rana, Prasanna Padmanaban, Malin Becker, Fabian Stein, Jeroen Leijten, Bart Koopman, Jeroen Rouwkema
Summary: Given the need for control over evolving biochemical cues within synthetic matrices, this study focused on the incorporation of VEGF165 specific aptamers into cell-instructive polymer networks to regulate VEGF bioactivity. Bicomponent micropatterns were fabricated via photopatterning and demonstrated the retention of aptamers, molecular recognition, and VEGF sequestration. The study also revealed the ability of aptamer-tethered VEGF to spatiotemporally regulate vascular morphogenesis.
MATERIALS TODAY BIO
(2023)
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Article
Chemistry, Multidisciplinary
Feiyi Yang, Qian Zhang, Qiuyan Guo, Qingshan Pan, Chunping Wen, Xinya Lv, Wufu Zhu, Pengwu Zheng
Summary: A class of 4-phenoxy-pyridine/pyrimidine derivatives were synthesized and evaluated as potent dual VEGFR-2/c-Met inhibitors. Among them, compound 23k showed excellent anti-cancer cell proliferative activity and low toxicity. Further studies demonstrated that compound 23k induced apoptosis and blocked the cell cycle. Molecular docking and simulation revealed the binding modes of 23k to VEGFR-2 and c-Met.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Mannon Geindreau, Francois Ghiringhelli, Melanie Bruchard
Summary: VEGF plays a crucial role in tumor growth by promoting angiogenesis and modulating the immune response. Clinical approval has been given to therapies targeting VEGF for the treatment of various cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Kathryn N. Phoenix, Zhichao Yue, Lixia Yue, Chunxia G. Cronin, Bruce T. Liang, Luke H. Hoeppner, Kevin P. Claffey
Summary: This study identifies PLC beta 2 as a key regulator of vascular permeability induced by VEGF, functioning through regulation of calcium flux and phosphatidylinositol 4,5-bisphosphate levels. Targeting PLC beta 2 could provide a novel approach to regulate vascular permeability in patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Mechanics
Jyotsana Priyadarshani, Prasoon Awasthi, Pratyaksh Karan, Soumen Das, Suman Chakraborty
Summary: This study presents a simulation mimicking tumor angiogenesis microenvironment on-chip, aiming to establish favorable conditions for gradients of vascular endothelial growth factor. The model platform explores different responses of endothelial cells in a micro-confined fluidic environment, showing potential significance for organ-on-a-chip assays, disease modeling, and optimizing anti-angiogenic therapies.
Article
Hematology
Diego Butera, Haoqing Jerry Wang, Heng-Giap Woon, Yunduo Charles Zhao, Lining Arnold Ju, Philip J. Hogg
Summary: von Willebrand factor (VWF) acts as a protective carrier for procoagulant factor VIII (FVIII) in the circulation, forming a strong bond characterized by catch-bond behavior. Mutations in VWF at the FVIII binding site can lead to hemophilia A-like phenotypes, primarily affecting cysteine residues involved in disulfide bond formation. Interaction between VWF and FVIII involves dynamic changes in the covalent states of VWF disulfide bonds, which are essential for productive interaction under physiological shear forces.
Article
Hematology
Angelina J. Lay, Alexander Dupuy, Lejla Hagimola, Jessica Tieng, Mark Larance, Yunwei Zhang, Jean Yang, Yvonne Kong, Joyce Chiu, Emilia Gray, Zihao Qin, Diana Schmidt, Jessica Maclean, Benjamin Hofma, Marc Ellis, Maggie Kalev-Zylinska, Yair Argon, Shaun P. Jackson, Philip Hogg, Freda H. Passam
Summary: This study found that ERp5 plays a negative regulatory role in platelet ER stress response and highlights the importance of disulfide isomerases in platelet ER homeostasis. Furthermore, the study also revealed the close correlation between platelet ER stress and platelet secretion and thrombosis.
Article
Cardiac & Cardiovascular Systems
Alexander Dupuy, Camilo Aponte-Santamaria, Adva Yeheskel, Elinor Hortle, Stefan H. Oehlers, Frauke Graeter, Philip J. Hogg, Freda H. Passam, Joyce Chiu
Summary: This study found that protein disulfide isomerase (PDI) promotes directional migration of neutrophils during inflammation by cleaving the Mac-1 C224-C264 disulfide bond, leading to the dissociation of Mac-1 from ICAM-1.
CIRCULATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jianwei Lin, Yiping Wu, Gaofei Tian, Daqi Yu, Eunjeong Yang, Wai Hei Lam, Zheng Liu, Yihang Jing, Shangyu Dang, Xiucong Bao, Jason Wing Hon Wong, Yuanliang Zhai, Xiang David Li
Summary: H3K79me2 is an important epigenetic mark involved in gene regulation, cellular differentiation, and disease progression. A nucleosome-based photoaffinity probe was used to identify menin as a reader of H3K79me2 in a nucleosomal context. Cryo-electron microscopy showed that menin interacts with the nucleosome through specific domains and recognizes the methylation mark through a p-cation interaction. In cells, menin is selectively associated with H3K79me2 on chromatin, particularly in gene bodies.
Article
Multidisciplinary Sciences
Ian C. H. Lee, Sergey Tumanov, Jason W. H. Wong, Roland Stocker, Joshua W. K. Ho
Summary: Mass spectrometry-based untargeted metabolomic and lipidomic approaches are widely used in biomedical research. A sample extraction method called Multi-ABLE has been developed for concurrent generation of proteomic, metabolomic, and lipidomic data. However, there is a lack of a unified bioinformatics pipeline for processing and analysis of these data. A new R pipeline called MultiABLER is presented here as a unified and simple upstream processing and analysis pipeline for metabolomics and lipidomics datasets.
Article
Health Care Sciences & Services
Aya El Helali, Tai-Chung Lam, Elaine Yee-Ling Ko, David J. H. Shih, Chun Kau Chan, Charlene H. L. Wong, Jason W. H. Wong, Lydia W. T. Cheung, Johnny K. S. Lau, Anthony P. Y. Liu, Ann S. Y. Chan, Herbert H. Loong, Stephen Tak Sum Lam, Godfrey Chi-Fung Chan, Victor H. F. Lee, Kwok Keung Yuen, Wai-Tong Ng, Anne W. M. Lee, Edmond S. K. Ma
Summary: This study investigated the feasibility of the HKU-HKSH Multi-disciplinary Molecular Tumour Board (MTB) in determining genome-guided therapy for treatment-refractory solid cancers in Hong Kong. The results showed that MTB-guided treatment positively impacted patients' overall survival, illustrating the applicability of next-generation sequencing comprehensive gene profiling (CGP) in real-world clinical practice.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Hematology
Moua Yang, Joyce Chiu, Christina Scartelli, Nathan Ponzar, Sachin Patel, Anika Patel, Renan B. Ferreira, Robert F. Keyes, Kate S. Carroll, Nicola Pozzi, Philip J. Hogg, Brian C. Smith, Robert Flaumenhaft
Summary: Oxidative stress leads to protein damage and inactivation. PDI is disrupted during oxidative stress, resulting in thrombus formation. Inhibiting PDI disruption can reduce thrombus formation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Fabian Kutzki, Diego Butera, Angelina J. Lay, Denis Maag, Joyce Chiu, Heng-Giap Woon, Tomas Kubar, Marcus Elstner, Camilo Aponte-Santamaria, Philip J. Hogg, Frauke Graeter
Summary: This study revealed the oxidation state of disulfide bridges in the VWF-C4 domain and its implications for VWF's platelet binding function. It was found that two major force-bearing disulfide bonds are partially reduced in human blood, leading to conformational changes within C4 that affect the accessibility of the integrin-binding motif and impair integrin-mediated platelet binding. Additionally, specific thiol/disulfide exchanges between the reduced species and the remaining disulfide bridges were observed, with mechanical force potentially enhancing the proximity of reactant cysteines and further affecting integrin binding propensity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Oncology
Hu Fang, Johanna Bertl, Xiaoqiang Zhu, Tai Chung Lam, Song Wu, David J. H. Shih, Jason W. H. Wong
Summary: Tumour mutational burden (TMB) is a predictive marker for immune checkpoint inhibitor (ICI) responsiveness, but its calculation using different genomic regions is unclear. This study found that cancer gene-based panels usually overestimate TMB compared to whole exome, potentially leading to misclassification of patients for ICI treatment. A statistical model was developed to unify TMB calculations and improve patient stratification for ICI treatment.
JOURNAL OF THE NATIONAL CANCER CENTER
(2023)
Meeting Abstract
Oncology
Xiaoqiang Zhu, Hai Wang, Xuefeng Pan, Jie Hong, Jason Wing Hon Wong, Haoyan Chen, Youwei Zhang
Meeting Abstract
Oncology
Xiaoqiang Zhu, Hai Wang, Xuefeng Pan, Jie Hong, Jason Wing Hon Wong, Haoyan Chen, Youwei Zhang
