Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

(2016) Amanda W. Lund et al.   JOURNAL OF CLINICAL INVESTIGATION

The "cancer immunogram"

(2016) C. U. Blank et al.   SCIENCE

Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma

(2016) Hiroyuki Inoue et al.   OncoImmunology

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Humoral Immune Response against Nontargeted Tumor Antigens after Treatment with Sipuleucel-T and Its Association with Improved Clinical Outcome

(2015) D. GuhaThakurta et al.   CLINICAL CANCER RESEARCH

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma

(2015) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice

(2015) Mathias Schmaler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymphatic Vessels, Inflammation, and Immunity in Skin Cancer

(2015) A. W. Lund et al.   Cancer Discovery

Mechanisms of lymphatic metastasis

(2014) Sinem Karaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging roles of lymphatic endothelium in regulating adaptive immunity

(2014) Catherine M. Card et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+T cell tolerance

(2014) Juan Dubrot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Steady-State Antigen Scavenging, Cross-Presentation, and CD8+ T Cell Priming: A New Role for Lymphatic Endothelial Cells

(2014) S. Hirosue et al.   JOURNAL OF IMMUNOLOGY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

(2014) M. A. Swartz   Cancer Immunology Research

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

(2014) L. Jeanbart et al.   Cancer Immunology Research

Predictive Gene Signature in MAGE-A3 Antigen-Specific Cancer Immunotherapy

(2013) Fernando Ulloa-Montoya et al.   JOURNAL OF CLINICAL ONCOLOGY

Lymphatic biomarkers in primary melanomas as predictors of regional lymph node metastasis and patient outcomes

(2013) Sandro Pasquali et al.   Pigment Cell & Melanoma Research

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

(2012) E. F. Tewalt et al.   BLOOD

Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferation

(2012) Miriam Nörder et al.   FASEB JOURNAL

Lymphatic vessel density in primary melanomas predicts sentinel lymph node status and risk of metastasis

(2012) Ramin Shayan et al.   HISTOPATHOLOGY

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

An immune-active tumor microenvironment favors clinical response to ipilimumab

(2011) Rui-Ru Ji et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antigen Spreading Contributes to MAGE Vaccination-Induced Regression of Melanoma Metastases

(2011) Véronique Corbière et al.   CANCER RESEARCH

Vaccination-induced functional competence of circulating human tumor-specific CD8 T-cells

(2011) Petra Baumgaertner et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

(2010) Elizabeth D. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

(2010) Anne L. Fletcher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

(2009) H. Harlin et al.   CANCER RESEARCH

Vascular Endothelial Growth Factor-C and C-C Chemokine Receptor 7 in Tumor Cell-Lymphatic Cross-talk Promote Invasive Phenotype

(2008) A. Issa et al.   CANCER RESEARCH

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER