Cannabis sativa: Interdisciplinary Strategies and Avenues for Medical and Commercial Progression Outside of CBD and THC

Endocannabinoid reactivity to acute stress: Investigation of the relationship between salivary and plasma levels

(2021) Luke Ney et al.   BIOLOGICAL PSYCHOLOGY

Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models

(2020) Yuko Iwata et al.   LABORATORY INVESTIGATION

Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects

(2020) Christopher S. Pauli et al.   Frontiers in Pharmacology

Novel approaches and current challenges with targeting the endocannabinoid system

(2020) Paula Morales et al.   Expert Opinion on Drug Discovery

Serious adverse effects of cannabidiol (CBD): a review of randomized controlled trials

(2020) Rafael G. Dos Santos et al.   Expert Opinion on Drug Metabolism & Toxicology

A high-quality reference genome of wild Cannabis sativa

(2020) Shan Gao et al.   Horticulture Research

Can Hemp Help? Low-THC Cannabis and Non-THC Cannabinoids for the Treatment of Cancer

(2020) Farjana Afrin et al.   Cancers

Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602

(2020) Tiyyaba Furqan et al.   Biomolecules

Cannabidivarin for HIV‐associated neuropathic pain – a randomized, blinded, controlled clinical trial

(2020) Luca Eibach et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Beneficial effects of the phytocannabinoid Δ9-THCV in L-DOPA-induced dyskinesia in Parkinson's disease

(2020) Isabel Espadas et al.   NEUROBIOLOGY OF DISEASE

Simultaneous quantification of steroid hormones and endocannabinoids (ECs) in human hair using an automated supported liquid extraction (SLE) and LC-MS/MS – insights into EC baseline values and correlation to steroid concentrations

(2020) Clarissa Daniela Voegel et al.   TALANTA

Simultaneous quantification of endocannabinoids, oleoylethanolamide and steroid hormones in human plasma and saliva

(2020) Luke J. Ney et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Phytocannabinoid Pharmacology: Medicinal Properties of Cannabis sativa Constituents Aside from the “Big Two”

(2020) Peter B. Sampson   JOURNAL OF NATURAL PRODUCTS

In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa

(2020) Ayat Zagzoog et al.   Scientific Reports

Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD

(2020) Luke J. Ney et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Crystal Structure of the Human Cannabinoid Receptor CB2

(2019) Xiaoting Li et al.   CELL

A cell-free platform for the prenylation of natural products and application to cannabinoid production

(2019) Meaghan A. Valliere et al.   Nature Communications

Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

(2019) Xiaozhou Luo et al.   NATURE

A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential

(2019) C. Michael White   JOURNAL OF CLINICAL PHARMACOLOGY

Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain

(2019) Hayes Wong et al.   ARCHIVES OF ORAL BIOLOGY

The use of cannabinoids for sleep: A critical review on clinical trials.

(2019) Nirushi Kuhathasan et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Preclinical safety and efficacy of cannabidivarin for early life seizures

(2019) Megan N. Huizenga et al.   NEUROPHARMACOLOGY

Gene Networks Underlying Cannabinoid and Terpenoid Accumulation in Cannabis

(2019) Jordan J Zager et al.   PLANT PHYSIOLOGY

Architecture and Florogenesis in Female Cannabis sativa Plants

(2019) Ben Spitzer-Rimon et al.   Frontiers in Plant Science

Closing the Yield Gap for Cannabis: A Meta-Analysis of Factors Determining Cannabis Yield

(2019) Rachel Backer et al.   Frontiers in Plant Science

Terpenes in Cannabis sativa – From plant genome to humans

(2019) Judith K. Booth et al.   PLANT SCIENCE

Cannabinoid interventions for PTSD: Where to next?

(2019) Luke J. Ney et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cannabichromene is a cannabinoid CB2 receptor agonist

(2019) Michael Udoh et al.   BRITISH JOURNAL OF PHARMACOLOGY

The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients

(2019) E. Pagano et al.   PHARMACOLOGICAL RESEARCH

Impact of N, P, K, and Humic Acid Supplementation on the Chemical Profile of Medical Cannabis (Cannabis sativa L)

(2019) Nirit Bernstein et al.   Frontiers in Plant Science

The TRPV2 cation channels: from urothelial cancer invasiveness to glioblastoma multiforme interactome signature

(2019) Giorgio Santoni et al.   LABORATORY INVESTIGATION

Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy

(2019) Charlotte M Pretzsch et al.   Translational Psychiatry

A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents

(2019) Rati Kailash Prasad Tripathi   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isolation of a High-Affinity Cannabinoid for the Human CB1 Receptor from a Medicinal Cannabis sativa Variety: Δ9-Tetrahydrocannabutol, the Butyl Homologue of Δ9-Tetrahydrocannabinol

(2019) Pasquale Linciano et al.   JOURNAL OF NATURAL PRODUCTS

Screening of different Iranian ecotypes of cannabis under water deficit stress

(2019) Mehdi Babaei et al.   SCIENTIA HORTICULTURAE

A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol

(2019) Cinzia Citti et al.   Scientific Reports

Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation

(2018) Madhur P. Motwani et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Localization of cannabinoid receptors CB1, CB2, GPR55, and PPARα in the canine gastrointestinal tract

(2018) Giorgia Galiazzo et al.   HISTOCHEMISTRY AND CELL BIOLOGY

In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid

(2018) Agnese Gugliandolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence

(2018) Emily Stockings et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Modulation of the endocannabinoid system by sex hormones: Implications for Posttraumatic Stress Disorder

(2018) Luke John Ney et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

(2018) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR for Crop Improvement: An Update Review

(2018) Deepa Jaganathan et al.   Frontiers in Plant Science

Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice

(2018) Fabio Arturo Iannotti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome

(2018) Daniele Vigli et al.   NEUROPHARMACOLOGY

The opium poppy genome and morphinan production

(2018) Li Guo et al.   SCIENCE

Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells

(2018) Chiara Russo et al.   ARCHIVES OF TOXICOLOGY

Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis

(2018) Simona Lattanzi et al.   DRUGS

A physical and genetic map of Cannabis sativa identifies extensive rearrangements at the THC/CBD acid synthase loci

(2018) Kaitlin U. Laverty et al.   GENOME RESEARCH

Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

(2018) Nilo Riva et al.   LANCET NEUROLOGY

The legal status of cannabis (marijuana) and cannabidiol (CBD) under U.S. law

(2017) Alice Mead   EPILEPSY & BEHAVIOR

Endocannabinoids: Effectors of glucocorticoid signaling

(2017) Georgia Balsevich et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Dwarf germplasm: the key to giant Cannabis hempseed and cannabinoid crops

(2017) Ernest Small   GENETIC RESOURCES AND CROP EVOLUTION

Plant density and nitrogen fertilization affect agronomic performance of industrial hemp ( Cannabis sativa L.) in Mediterranean environment

(2017) Enio Campiglia et al.   INDUSTRIAL CROPS AND PRODUCTS

Engineering yeasts as platform organisms for cannabinoid biosynthesis

(2017) Bastian Zirpel et al.   JOURNAL OF BIOTECHNOLOGY

CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets

(2017) Shengdar Q Tsai et al.   NATURE METHODS

GPR55: A therapeutic target for Parkinson's disease?

(2017) Marta Celorrio et al.   NEUROPHARMACOLOGY

Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder

(2017) Matthew N Hill et al.   NEUROPSYCHOPHARMACOLOGY

The endocannabinoid system as a target for novel anxiolytic drugs

(2017) Sachin Patel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Terpene synthases from Cannabis sativa

(2017) Judith K. Booth et al.   PLoS One

Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice

(2017) Lawrence M. Carey et al.   Scientific Reports

An update on PPAR activation by cannabinoids

(2016) Saoirse Elizabeth O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Cannabis Domestication, Breeding History, Present-day Genetic Diversity, and Future Prospects

(2016) Robert C. Clarke et al.   CRITICAL REVIEWS IN PLANT SCIENCES

Genomic and Chemical Diversity in Cannabis

(2016) Ryan C. Lynch et al.   CRITICAL REVIEWS IN PLANT SCIENCES

Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair

(2016) Christopher Mwanza et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Medical Cannabis Use Is Associated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients With Chronic Pain

(2016) Kevin F. Boehnke et al.   JOURNAL OF PAIN

Phytocannabinoids: a unified critical inventory

(2016) Lumír Ondřej Hanuš et al.   NATURAL PRODUCT REPORTS

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

(2016) Alessia Ligresti et al.   PHYSIOLOGICAL REVIEWS

Potential of the cannabinoid CB2 receptor as a pharmacological target against inflammation in Parkinson's disease

(2016) Yolanda Gómez-Gálvez et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Genetic basis for glandular trichome formation in cotton

(2016) Dan Ma et al.   Nature Communications

Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease

(2016) Hayate Javed et al.   Frontiers in Neuroscience

The complete mitochondrial genome for Cannabis sativa

(2016) Kristin H. White et al.   Mitochondrial DNA Part B-Resources

Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism

(2016) Isabel González-Mariscal et al.   Scientific Reports

Hippocampal neuronal maturation triggers post-synaptic clustering of brain temperature-sensor TRPV4

(2015) Koji Shibasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The CRISPR/Cas9 system for plant genome editing and beyond

(2015) Luisa Bortesi et al.   BIOTECHNOLOGY ADVANCES

Production of Δ9-tetrahydrocannabinolic acid from cannabigerolic acid by whole cells of Pichia (Komagataella) pastoris expressing Δ9-tetrahydrocannabinolic acid synthase from Cannabis sativa l.

(2015) Bastian Zirpel et al.   BIOTECHNOLOGY LETTERS

Letter to the Editor: Small, Ernest. 2015. Evolution and Classification of Cannabis sativa (Marijuana, Hemp) in Relation to Human Utilization. Botanical Review 81(3): 189-294

(2015) Robert C. Clarke et al.   BOTANICAL REVIEW

Evolution and Classification of Cannabis sativa (Marijuana, Hemp) in Relation to Human Utilization

(2015) Ernest Small   BOTANICAL REVIEW

The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act through 5-HT1Areceptors to produce antipsychotic effects

(2015) Maria Grazia Cascio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage

(2015) Charlotte Lorin et al.   CARDIOVASCULAR RESEARCH

Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development

(2015) Emilie Heckel et al.   CURRENT BIOLOGY

Editing plant genomes with CRISPR/Cas9

(2015) Khaoula Belhaj et al.   CURRENT OPINION IN BIOTECHNOLOGY

Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy

(2015) Craig A. Press et al.   EPILEPSY & BEHAVIOR

Characterisation of cannabinoid composition in a diverse Cannabis sativa L. germplasm collection

(2015) Matthew T. Welling et al.   EUPHYTICA

Size matters: evolution of large drug-secreting resin glands in elite pharmaceutical strains of Cannabis sativa (marijuana)

(2015) Ernest Small et al.   GENETIC RESOURCES AND CROP EVOLUTION

Key cultivation techniques for hemp in Europe and China

(2015) S. Amaducci et al.   INDUSTRIAL CROPS AND PRODUCTS

New developments in fiber hemp (Cannabis sativa L.) breeding

(2015) Elma M.J. Salentijn et al.   INDUSTRIAL CROPS AND PRODUCTS

The CB1 Neutral Antagonist Tetrahydrocannabivarin Reduces Default Mode Network and Increases Executive Control Network Resting State Functional Connectivity in Healthy Volunteers

(2015) Ewelina Rzepa et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers

(2015) Luke Tudge et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cannabinoids for Medical Use

(2015) Penny F. Whiting et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial

(2015) Amir Englund et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications

(2015) Padmashree C. G. Rida et al.   MEDICINAL RESEARCH REVIEWS

Two complete chloroplast genome sequences ofCannabis sativavarieties

(2015) Hyehyun Oh et al.   Mitochondrial DNA

A Robust CRISPR/Cas9 System for Convenient, High-Efficiency Multiplex Genome Editing in Monocot and Dicot Plants

(2015) Xingliang Ma et al.   Molecular Plant

DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins

(2015) Je Wook Woo et al.   NATURE BIOTECHNOLOGY

The endocannabinoid system in guarding against fear, anxiety and stress

(2015) Beat Lutz et al.   NATURE REVIEWS NEUROSCIENCE

Cannabidiol as a Potential Treatment for Anxiety Disorders

(2015) Esther M. Blessing et al.   Neurotherapeutics

Cannabinoids and Epilepsy

(2015) Evan C. Rosenberg et al.   Neurotherapeutics

Gene duplication and divergence affecting drug content inCannabis sativa

(2015) George D. Weiblen et al.   NEW PHYTOLOGIST

Sequence heterogeneity of cannabidiolic- and tetrahydrocannabinolic acid-synthase in Cannabis sativa L. and its relationship with chemical phenotype

(2015) Chiara Onofri et al.   PHYTOCHEMISTRY

Cas9-Guide RNA Directed Genome Editing in Soybean

(2015) Zhongsen Li et al.   PLANT PHYSIOLOGY

A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation

(2015) Levi G. Lowder et al.   PLANT PHYSIOLOGY

Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein

(2015) T. Winzer et al.   SCIENCE

Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability

(2014) Fabio Arturo Iannotti et al.   ACS Chemical Neuroscience

Conversion of Thebaine to Oripavine and Other Useful Intermediates for the Semisynthesis of Opiate-Derived Agents: Synthesis of Hydromorphone

(2014) Brennan Murphy et al.   ADVANCED SYNTHESIS & CATALYSIS

A CRISPR/Cas9 toolkit for multiplex genome editing in plants

(2014) Hui-Li Xing et al.   BMC PLANT BIOLOGY

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid

(2014) Francesca Borrelli et al.   CARCINOGENESIS

Analysis of the genetic diversity of Chinese native Cannabis sativa cultivars by using ISSR and chromosome markers

(2014) L.G. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew

(2014) Yanpeng Wang et al.   NATURE BIOTECHNOLOGY

Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice

(2014) Sara Valdeolivas et al.   Neurotherapeutics

Differences in receptor binding affinity of several phytocannabinoids do not explain their effects on neural cell cultures

(2014) Sarah Rosenthaler et al.   NEUROTOXICOLOGY AND TERATOLOGY

Targeted mutation of Δ12 and Δ15 desaturase genes in hemp produce major alterations in seed fatty acid composition including a high oleic hemp oil

(2014) Monika Bielecka et al.   PLANT BIOTECHNOLOGY JOURNAL

Economic Analysis of Greenhouse Lighting: Light Emitting Diodes vs. High Intensity Discharge Fixtures

(2014) Jacob A. Nelson et al.   PLoS One

Diversity Analysis in Cannabis sativa Based on Large-Scale Development of Expressed Sequence Tag-Derived Simple Sequence Repeat Markers

(2014) Chunsheng Gao et al.   PLoS One

A comparison of cannabidiolic acid with other treatments for anticipatory nausea using a rat model of contextually elicited conditioned gaping

(2014) Erin M. Rock et al.   PSYCHOPHARMACOLOGY

General Method of Synthesis for Naloxone, Naltrexone, Nalbuphone, and Nalbuphine by the Reaction of Grignard Reagents with an Oxazolidine Derived from Oxymorphone

(2013) Mary Ann A. Endoma-Arias et al.   ADVANCED SYNTHESIS & CATALYSIS

Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis

(2013) Eva Vranová et al.   Annual Review of Plant Biology

Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease

(2013) Francesca Borrelli et al.   BIOCHEMICAL PHARMACOLOGY

Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1receptor-independent mechanism

(2013) T D M Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

(2013) B Romano et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease

(2013) Luqing Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blockade of sarcolemmal TRPV2 accumulation inhibits progression of dilated cardiomyopathy

(2013) Yuko Iwata et al.   CARDIOVASCULAR RESEARCH

Efficient genome editing in plants using a CRISPR/Cas system

(2013) Zhengyan Feng et al.   CELL RESEARCH

The Medical Necessity for Medicinal Cannabis: Prospective, Observational Study Evaluating the Treatment in Cancer Patients on Supportive or Palliative Care

(2013) Gil Bar-Sela et al.   Evidence-based Complementary and Alternative Medicine

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9

(2013) Jian-Feng Li et al.   NATURE BIOTECHNOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The effect of cannabichromene on adult neural stem/progenitor cells

(2013) Noriko Shinjyo et al.   NEUROCHEMISTRY INTERNATIONAL

A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice

(2013) Kun Li et al.   NEUROPHARMACOLOGY

Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice

(2013) Wenzhi Jiang et al.   NUCLEIC ACIDS RESEARCH

GPR55, a G-Protein Coupled Receptor for Lysophosphatidylinositol, Plays a Role in Motor Coordination

(2013) Chia-Shan Wu et al.   PLoS One

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair

(2013) Aniko Krumbholz et al.   THERAPEUTIC DRUG MONITORING

Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

(2013) Nancy Podevin et al.   TRENDS IN BIOTECHNOLOGY

The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity

(2013) E T Wargent et al.   Nutrition & Diabetes

Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression

(2013) Naoki Amada et al.   PeerJ

UnexpectedN-Demethylation of Oxymorphone and OxycodoneN-Oxides Mediated by the Burgess Reagent: Direct Synthesis of Naltrexone, Naloxone, and Other Antagonists from Oxymorphone

(2012) Lukas Werner et al.   ADVANCED SYNTHESIS & CATALYSIS

Improved Synthesis of Buprenorphine from Thebaine and/or Oripavine via Palladium-Catalyzed N-Demethylation/Acylation and/or Concomitant O-Demethylation

(2012) Ales Machara et al.   ADVANCED SYNTHESIS & CATALYSIS

Multiple Functions of Endocannabinoid Signaling in the Brain

(2012) István Katona et al.   Annual Review of Neuroscience

The Endocannabinoid System and the Brain

(2012) Raphael Mechoulam et al.   Annual Review of Psychology

Effects of abscisic acid on content and biosynthesis of terpenoids in Cannabis sativa at vegetative stage

(2012) H. Mansouri et al.   BIOLOGIA PLANTARUM

Cannabidivarin is anticonvulsant in mouse and rat

(2012) AJ Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice

(2012) Angelo A Izzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

The carbon footprint of indoor Cannabis production

(2012) Evan Mills   ENERGY POLICY

Functional TRPV1 expression in human corneal fibroblasts

(2012) Yuanquan Yang et al.   EXPERIMENTAL EYE RESEARCH

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

(2012) Wei Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure and Function of ∆1-Tetrahydrocannabinolic Acid (THCA) Synthase, the Enzyme Controlling the Psychoactivity of Cannabis sativa

(2012) Yoshinari Shoyama et al.   JOURNAL OF MOLECULAR BIOLOGY

Cycloheximide as a tool to investigate protein import in peroxisomes: A case study of the subcellular localization of isoprenoid biosynthetic enzymes

(2012) Grégory Guirimand et al.   JOURNAL OF PLANT PHYSIOLOGY

Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT2A and dopamine D2 receptors in rat prefrontal cortex

(2012) Jade M Franklin et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission

(2012) Alejandro Aparisi Rey et al.   NEUROPSYCHOPHARMACOLOGY

Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology

(2012) Vinogran Naidoo et al.   Neurotherapeutics

Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Contractility in Mice

(2012) Gracious R. Ross et al.   PHARMACOLOGY

Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures

(2012) Rudolf Moldzio et al.   PHYTOMEDICINE

The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes

(2012) Jake M. Stout et al.   PLANT JOURNAL

Endocannabinoids Measurement in Human Saliva as Potential Biomarker of Obesity

(2012) Isabelle Matias et al.   PLoS One

Differences in the Endocannabinoid System of Sperm from Fertile and Infertile Men

(2012) Sheena E. M. Lewis et al.   PLoS One

Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides

(2012) S. J. Gagne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

(2012) T. Winzer et al.   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT2A) receptor activity via ERK1/2 signaling

(2012) Jade M. Franklin et al.   SYNAPSE

Cannabisol, a novel Δ9-THC dimer possessing a unique methylene bridge, isolated from Cannabis sativa

(2012) Fazila Zulfiqar et al.   TETRAHEDRON LETTERS

Agrobacteriuminfection of hemp (Cannabis sativaL.): establishment of hairy root cultures

(2012) Imane Wahby et al.   Journal of Plant Interactions

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

(2012) F M Leweke et al.   Translational Psychiatry

Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation

(2011) L. De Petrocellis et al.   Acta Physiologica

Cannabis in Palliative Medicine: Improving Care and Reducing Opioid-Related Morbidity

(2011) Gregory T. Carter et al.   American Journal of Hospice & Palliative Medicine

Terpene Biosynthesis: Modularity Rules

(2011) Eric Oldfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson's disease

(2011) C García et al.   BRITISH JOURNAL OF PHARMACOLOGY

Factors determining yield and quality of illicit indoor cannabis (Cannabis spp.) production

(2011) Wouter Vanhove et al.   FORENSIC SCIENCE INTERNATIONAL

Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids

(2011) Sharon Anavi-Goffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of Electrical Lighting Power and Irradiance on Indoor-Grown Cannabis Potency and Yield

(2011) David J. Potter et al.   JOURNAL OF FORENSIC SCIENCES

Estimation of reference intervals of five endocannabinoids and endocannabinoid related compounds in human plasma by two dimensional-LC/MS/MS

(2011) Flaminia Fanelli et al.   JOURNAL OF LIPID RESEARCH

Bioactive Prenylogous Cannabinoid from Fiber Hemp (Cannabis sativa)

(2011) Federica Pollastro et al.   JOURNAL OF NATURAL PRODUCTS

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

The subcellular localization of periwinkle farnesyl diphosphate synthase provides insight into the role of peroxisome in isoprenoid biosynthesis

(2011) Insaf Thabet et al.   JOURNAL OF PLANT PHYSIOLOGY

Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia

(2011) Wei Xiong et al.   Nature Chemical Biology

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents

(2011) X.-H. Lin et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55

(2011) Niklas Schuelert et al.   NEUROSCIENCE LETTERS

Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels

(2011) Sangsu Bang et al.   PAIN

Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing

(2011) Champa P. Wijekoon et al.   PLANT JOURNAL

Phenotypic and Genomic Analyses of a Fast Neutron Mutant Population Resource in Soybean

(2011) Y.-T. Bolon et al.   PLANT PHYSIOLOGY

Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta

(2011) Andrew J. Simkin et al.   PLANTA

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

(2011) Giuseppe Esposito et al.   PLoS One

Cannabioxepane, a novel tetracyclic cannabinoid from hemp, Cannabis sativa L.

(2011) Alberto Pagani et al.   TETRAHEDRON

Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism

(2011) M Donadelli et al.   Cell Death & Disease

The draft genome and transcriptome of Cannabis sativa

(2011) Harm van Bakel et al.   GENOME BIOLOGY

Temperature response of photosynthesis in different drug and fiber varieties of Cannabis sativa L.

(2011) Suman Chandra et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization

(2010) Maggie P. Y. Lam et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Enzymes of the mevalonate pathway of isoprenoid biosynthesis

(2010) Henry M. Miziorko   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells

(2010) Kyota Aoyagi et al.   BIOCHEMICAL JOURNAL

Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes

(2010) Satoshi Yamaori et al.   BIOCHEMICAL PHARMACOLOGY

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease

(2010) Cristina Blázquez et al.   BRAIN

The plant cannabinoid Δ9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice

(2010) Daniele Bolognini et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR55 ligands promote receptor coupling to multiple signalling pathways

(2010) Christopher M Henstridge et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes

(2010) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis

(2010) A. Preet et al.   Cancer Prevention Research

Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ9-tetrahydrocannabinol☆

(2010) Gerald T. DeLong et al.   DRUG AND ALCOHOL DEPENDENCE

Δ9-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats

(2010) Andrew J. Hill et al.   EPILEPSIA

Cannabimovone, a Cannabinoid with a Rearranged Terpenoid Skeleton from Hemp (Eur. J. Org. Chem. 11/2010)

(2010) Orazio Taglialatela-Scafati et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

An artificial solar spectrum substantially alters plant development compared with usual climate room irradiance spectra

(2010) Sander W. Hogewoning et al.   JOURNAL OF EXPERIMENTAL BOTANY

Decarboxylation of Δ9-tetrahydrocannabinol: Kinetics and molecular modeling

(2010) Helene Perrotin-Brunel et al.   JOURNAL OF MOLECULAR STRUCTURE

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

The Isogene 1-Deoxy-D-Xylulose 5-Phosphate Synthase 2 Controls Isoprenoid Profiles, Precursor Pathway Allocation, and Density of Tomato Trichomes

(2010) Heike Paetzold et al.   Molecular Plant

Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis

(2010) Derick T Wade et al.   Multiple Sclerosis Journal

Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy

(2010) Jillian M Hagel et al.   Nature Chemical Biology

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

(2010) Tiffany M Link et al.   NATURE IMMUNOLOGY

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

AAV Vector-Mediated Overexpression of CB1 Cannabinoid Receptor in Pyramidal Neurons of the Hippocampus Protects against Seizure-Induced Excitoxicity

(2010) Stephan Guggenhuber et al.   PLoS One

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

(2010) I. A. Graham et al.   SCIENCE

Essential fatty acids, nutritive value and oxidative stability of cold pressed hempseed (Cannabis sativaL.) oil from different varieties

(2009) E. Dimić et al.   ACTA ALIMENTARIA

Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist

(2009) MG Cascio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception

(2009) Lamont Booker et al.   DRUG AND ALCOHOL DEPENDENCE

Buprenorphine/Naloxone

(2009) Jennifer S. Orman et al.   DRUGS

Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway

(2009) Futoshi Taura et al.   FEBS LETTERS

Overexpression of a Weed (Solanum americanum) Proteinase Inhibitor in Transgenic Tobacco Results in Increased Glandular Trichome Density and Enhanced Resistance to Helicoverpa armigera and Spodoptera litura

(2009) Ming Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of candidate genes affecting Δ9-tetrahydrocannabinol biosynthesis in Cannabis sativa

(2009) M. David Marks et al.   JOURNAL OF EXPERIMENTAL BOTANY

Effects of Gibberellic Acid on Primary Terpenoids and Δ9-Tetrahydrocannabinol inCannabis sativaat Flowering Stage

(2009) Hakimeh Mansouri et al.   Journal of Integrative Plant Biology

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer

(2009) Z. Qamri et al.   MOLECULAR CANCER THERAPEUTICS

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP

(2009) Sravan Mandadi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation

(2009) Vincenzo Di Marzo   PHARMACOLOGICAL RESEARCH

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

TRPA1 acts as a cold sensor in vitro and in vivo

(2009) Y. Karashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From dwarves to giants? Plant height manipulation for biomass yield

(2009) Maria G. Salas Fernandez et al.   TRENDS IN PLANT SCIENCE

Photosynthetic response of Cannabis sativa L. to variations in photosynthetic photon flux densities, temperature and CO2 conditions

(2009) Suman Chandra et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Ultra performance liquid chromatography tandem mass spectrometry method for the measurement of anandamide in human plasma

(2008) Patricia M.W. Lam et al.   ANALYTICAL BIOCHEMISTRY

Overexpression of the gene encoding HMG-CoA reductase in Saccharomyces cerevisiae for production of prenyl alcohols

(2008) Chikara Ohto et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effects of Δ9-tetrahydrocannabivarin on [35S]GTPγS binding in mouse brain cerebellum and piriform cortex membranes

(2008) I Dennis et al.   BRITISH JOURNAL OF PHARMACOLOGY

The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum

(2008) Y-L Ma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched dietThis article is one of a selection of papers published in the special issue Bridging the Gap: Where Progress in Cardiovascular and Neurophysiologic Research Meet.

(2008) M.A. Prociuk et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Antitumor activity of noscapine in human non-small cell lung cancer xenograft model

(2008) Tanise Jackson et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor  -Mediated Ceramide De novo Synthesis in Colon Cancer Cells

(2008) F. Cianchi et al.   CLINICAL CANCER RESEARCH

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic  -Cells

(2008) E. Hisanaga et al.   DIABETES

Peripheral, but Not Central, CB1 Antagonism Provides Food Intake-Independent Metabolic Benefits in Diet-Induced Obese Rats

(2008) R. Nogueiras et al.   DIABETES

Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models

(2008) Yuko Iwata et al.   HUMAN MOLECULAR GENETICS

Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression

(2008) M. Waldeck-Weiermair et al.   JOURNAL OF CELL SCIENCE

Cannabinoid Ester Constituents from High-PotencyCannabis sativa

(2008) Safwat A. Ahmed et al.   JOURNAL OF NATURAL PRODUCTS

TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons

(2008) N. Qin et al.   JOURNAL OF NEUROSCIENCE

One-Pot Conversion of Thebaine to Hydrocodone and Synthesis of Neopinone Ketal

(2008) Robert J. Carroll et al.   JOURNAL OF ORGANIC CHEMISTRY

Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8

(2008) L. De Petrocellis et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Genetic Evidence for the Role of Isopentenyl Diphosphate Isomerases in the Mevalonate Pathway and Plant Development in Arabidopsis

(2008) Kazunori Okada et al.   PLANT AND CELL PHYSIOLOGY

Characterisation of hemp (Cannabis sativa L.) roots under different growing conditions

(2008) Stefano Amaducci et al.   PLANT AND SOIL

Chloroplast localization of methylerythritol 4-phosphate pathway enzymes and regulation of mitochondrial genes in ispD and ispE albino mutants in Arabidopsis

(2008) Ming-Hsiun Hsieh et al.   PLANT MOLECULAR BIOLOGY

Peroxisomal Localization of Arabidopsis Isopentenyl Diphosphate Isomerases Suggests That Part of the Plant Isoprenoid Mevalonic Acid Pathway Is Compartmentalized to Peroxisomes

(2008) M. Sapir-Mir et al.   PLANT PHYSIOLOGY

Isolation and Characterization of New Cannabis Constituents from a High Potency Variety

(2008) Mohamed Radwan et al.   PLANTA MEDICA

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the CB1 receptor in the regulation of sleep

(2008) Eric Murillo-Rodríguez   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Structure determination and absolute configuration of cannabichromanone derivatives from high potency Cannabis sativa

(2008) Safwat A. Ahmed et al.   TETRAHEDRON LETTERS

The plastidial MEP pathway: unified nomenclature and resources

(2008) M PHILLIPS et al.   TRENDS IN PLANT SCIENCE

The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo

(2007) R G Pertwee et al.   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY