The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications

Inhalable nanostructured lipid particles of 9-bromo-noscapine, a tubulin-binding cytotoxic agent: In vitro and in vivo studies

(2015) Kiran Jyoti et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics

(2015) Manu Lopus et al.   Pharmacological Reports

Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity

(2014) Maged Henary et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and biological evaluation of novel biaryl type α-noscapine congeners

(2014) Naresh K. Manchukonda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel 9′-substituted-noscapines: Synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation

(2014) Elena Porcù et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antifibrotic Effects of Noscapine through Activation of Prostaglandin E2Receptors and Protein Kinase A

(2014) Jacob Kach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular insight of isotypes specific β-tubulin interaction of tubulin heterodimer with noscapinoids

(2014) Seneha Santoshi et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Epithelial transport of Noscapine across cell monolayer and influence of absorption enhancers onin vitropermeation and bioavailability: implications for intestinal absorption

(2014) Mahavir B. Chougule et al.   JOURNAL OF DRUG TARGETING

Cyclodextrin Complexes of Reduced Bromonoscapine in Guar Gum Microspheres Enhance Colonic Drug Delivery

(2014) Jitender Madan et al.   MOLECULAR PHARMACEUTICS

Acetylation serves as a protective group in noscapine biosynthesis in opium poppy

(2014) Thu-Thuy T Dang et al.   Nature Chemical Biology

Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death

(2014) A Ogden et al.   Cell Death & Disease

Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth

(2013) Qi Qi et al.   ACTA PHARMACOLOGICA SINICA

The Synthesis and Biological Evaluation of Multifunctionalised Derivatives of Noscapine as Cytotoxic Agents

(2013) Aaron J. DeBono et al.   ChemMedChem

Sterically stabilized gelatin microassemblies of noscapine enhance cytotoxicity, apoptosis and drug delivery in lung cancer cells

(2013) Jitender Madan et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

A Review on Noscapine, and its Impact on Heme Metabolism

(2013) Harpal Singh et al.   CURRENT DRUG METABOLISM

Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy

(2013) Thu-Thuy T. Dang et al.   FEBS LETTERS

CYP82Y1 IsN-Methylcanadine 1-Hydroxylase, a Key Noscapine Biosynthetic Enzyme in Opium Poppy

(2013) Thu-Thuy T. Dang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short-chain dehydrogenase/reductase catalyzing the final step of noscapine biosynthesis is localized to laticifers in opium poppy

(2013) Xue Chen et al.   PLANT JOURNAL

Rational Design, Synthesis, and Biological Evaluation of Third Generation α-Noscapine Analogues as Potent Tubulin Binding Anti-Cancer Agents

(2013) Naresh Kumar Manchukonda et al.   PLoS One

Do viruses require the cytoskeleton?

(2013) Jason D Matthews et al.   Virology Journal

Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro

(2012) Zi-Rong Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic map and bioactivation of the anti-tumour drug noscapine

(2012) Zhong-Ze Fang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis and Biological Evaluation ofN-Substituted Noscapine Analogues

(2012) Aaron J. DeBono et al.   ChemMedChem

Implications of Nanoscale Based Drug Delivery Systems in Delivery and Targeting Tubulin Binding Agent, Noscapine in Cancer Cells

(2012) Ramesh Chandra et al.   CURRENT DRUG METABOLISM

Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives

(2012) Youssef L. Bennani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells

(2012) Jitender Madan et al.   Nanomedicine-Nanotechnology Biology and Medicine

Management of Opioid Analgesic Overdose

(2012) Edward W. Boyer   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of Three O-Methyltransferases Involved in Noscapine Biosynthesis in Opium Poppy

(2012) T.-T. T. Dang et al.   PLANT PHYSIOLOGY

Noscapine Induced Apoptosis via Downregulation of Survivin in Human Neuroblastoma Cells Having Wild Type or Null p53

(2012) Shiwang Li et al.   PLoS One

A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

(2012) T. Winzer et al.   SCIENCE

Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach

(2012) V Pannu et al.   Cell Death & Disease

Long-circulating poly(ethylene glycol)-grafted gelatin nanoparticles customized for intracellular delivery of noscapine

(2011) Jitender Madan et al.   ANTI-CANCER DRUGS

Second generation benzofuranone ring substituted noscapine analogs: Synthesis and biological evaluation

(2011) Ram Chandra Mishra et al.   BIOCHEMICAL PHARMACOLOGY

Decreased therapeutic effects of noscapine combined with imatinib mesylate on human glioblastoma in vitro and the effect of midkine

(2011) Mine Erguven et al.   Cancer Cell International

Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α

(2011) Wenjing Su et al.   CANCER LETTERS

Noscapine inhibits tumor growth in TMZ-resistant gliomas

(2011) Niyati Jhaveri et al.   CANCER LETTERS

Determination of Noscapine’s Localization and Interaction with the Tubulin-α/β Heterodimer

(2011) Laleh Alisaraie et al.   Chemical Biology & Drug Design

Rational design, synthesis and biological evaluations of amino-noscapine: a high affinity tubulin-binding noscapinoid

(2011) Pradeep K. Naik et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Molecular modelling and competition binding study of Br-noscapine and colchicine provide insight into noscapinoid–tubulin binding site

(2011) Pradeep K. Naik et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Antitumor Activity of Noscapine in Combination with Doxorubicin in Triple Negative Breast Cancer

(2011) Mahavir B. Chougule et al.   PLoS One

Enhanced Anticancer Activity of Gemcitabine in Combination with Noscapine via Antiangiogenic and Apoptotic Pathway against Non-Small Cell Lung Cancer

(2011) Mahavir B. Chougule et al.   PLoS One

Synergistic antimicrotubule therapy for prostate cancer

(2010) Vaishali Pannu et al.   BIOCHEMICAL PHARMACOLOGY

Noscapine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo

(2010) Meng Liu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Noscapine, a Benzylisoquinoline Alkaloid, Sensitizes Leukemic Cells to Chemotherapeutic Agents and Cytokines by Modulating the NF- B Signaling Pathway

(2010) B. Sung et al.   CANCER RESEARCH

A novel microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cells

(2010) Ritu Aneja et al.   EUROPEAN JOURNAL OF CANCER

Induction of Reactive Oxygen Species-mediated Autophagy by a Novel Microtubule-modulating Agent

(2010) Prasanthi Karna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer

(2010) Mahavir Chougule et al.   LUNG CANCER

Potent Anti-Inflammatory Activity of Novel Microtubule-Modulating Brominated Noscapine Analogs

(2010) Susu Zughaier et al.   PLoS One

Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats

(2010) Anjali Priyadarshani et al.   Journal of Ovarian Research

Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction

(2009) Zhong-Ze Fang et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Inclusion complexes of noscapine in β-cyclodextrin offer better solubility and improved pharmacokinetics

(2009) Jitender Madan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Synthesis and characterization of noscapine loaded magnetic polymeric nanoparticles

(2009) Mohamed O. Abdalla et al.   JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

Antitumor activity of noscapine in human non-small cell lung cancer xenograft model

(2008) Tanise Jackson et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Thymoma, Myasthenia Gravis, and Other Paraneoplastic Syndromes

(2008) Laura M. Tormoehlen et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Antiangiogenic Effects of Noscapine Enhance Radioresponse for GL261 Tumors

(2008) Elizabeth W. Newcomb et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Noscapine may increase the effect of warfarin

(2007) Staffan Ohlsson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY