Terpene Biosynthesis: Modularity Rules

Characterization of the Rv3378c Gene Product, a New Diterpene Synthase for Producing Tuberculosinol and (13R,S)-Isotuberculosinol (Nosyberkol), from theMycobacterium tuberculosisH37Rv Genome

(2011) Chiaki NAKANO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

IspG-Catalyzed Positional Isotopic Exchange in Methylerythritol Cyclodiphosphate of the Deoxyxylulose Phosphate Pathway: Mechanistic Implications

(2011) Youli Xiao et al.   CHEMBIOCHEM

Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target

(2011) William Sinko et al.   Chemical Biology & Drug Design

Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase

(2011) Mustafa Köksal et al.   Nature Chemical Biology

Reductive Dehydroxylation of Allyl Alcohols by IspH Protein

(2010) Tobias Gräwert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lipophilic Bisphosphonates Are Potent Inhibitors of Plasmodium Liver-Stage Growth

(2010) A. P. Singh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enzymes of the mevalonate pathway of isoprenoid biosynthesis

(2010) Henry M. Miziorko   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms

(2010) Youli Xiao et al.   CHEMICAL COMMUNICATIONS

Structure of theE-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) fromThermus thermophilus

(2010) Ingo Rekittke et al.   FEBS LETTERS

Crystal Structure of Heterodimeric Hexaprenyl Diphosphate Synthase fromMicrococcus luteusB-P 26 Reveals That the Small Subunit Is Directly Involved in the Product Chain Length Regulation

(2010) Daisuke Sasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase fromPlasmodiumParasites

(2010) Jennifer D. Artz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lycopene Cyclase CrtY fromPantoea ananatis(FormerlyErwinia uredovora) Catalyzes an FADred-dependent Non-redox Reaction

(2010) Qiuju Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Substrate Specificity of Geranylgeranyl Reductases Revealed by the Structure of Digeranylgeranylglycerophospholipid Reductase, an Essential Enzyme in the Biosynthesis of Archaeal Membrane Lipids

(2010) Qingping Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

Biosynthesis of Isoprenoids: Crystal Structure of the [4Fe–4S] Cluster Protein IspG

(2010) Matthias Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of Isoprene Synthase Illuminates the Chemical Mechanism of Teragram Atmospheric Carbon Emission

(2010) Mustafa Köksal et al.   JOURNAL OF MOLECULAR BIOLOGY

The Structure of Formaldehyde-Inhibited Xanthine Oxidase Determined by 35 GHz2H ENDOR Spectroscopy

(2010) Muralidharan Shanmugam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Paramagnetic Intermediates of (E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate Synthase (GcpE/IspG) under Steady-State and Pre-Steady-State Conditions

(2010) Weiya Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Origins and Early Evolution of the Mevalonate Pathway of Isoprenoid Biosynthesis in the Three Domains of Life

(2010) J. Lombard et al.   MOLECULAR BIOLOGY AND EVOLUTION

Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis

(2010) Mustafa Köksal et al.   NATURE

Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme

(2010) Yang Zhang et al.   NATURE

Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery

(2010) Wolfgang Jahnke et al.   Nature Chemical Biology

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophagephagocytosis

(2010) Tsutomu Hoshino et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation

(2010) T.-H. Chang et al.   PLANT CELL

Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)

(2010) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioorganometallic mechanism of action, and inhibition, of IspH

(2010) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of action and inhibition of dehydrosqualene synthase

(2010) F.-Y. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diterpene cyclases and the nature of the isoprene fold

(2010) Rong Cao et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Trinuclear metal clusters in catalysis by terpenoid synthases

(2010) Julie A. Aaron et al.   PURE AND APPLIED CHEMISTRY

Gibberellin biosynthesis in bacteria: Separateent-copalyl diphosphate andent-kaurene synthases inBradyrhizobium japonicum

(2009) Dana Morrone et al.   FEBS LETTERS

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway

(2009) Marta Coscia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IspG Converts an Epoxide Substrate Analogue to (E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate: Implications for IspG Catalysis in Isoprenoid Biosynthesis

(2009) Rodney L. Nyland II et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermodynamics of Bisphosphonates Binding to Human Bone: A Two-Site Model

(2009) Sujoy Mukherjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

(2009) Yonghui Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Endocrine Therapy plus Zoledronic Acid in Premenopausal Breast Cancer

(2009) Michael Gnant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Probing the reaction mechanism of IspH protein by x-ray structure analysis

(2009) T. Grawert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Activities of ER-119884 and E5700, Two Potent Squalene Synthase Inhibitors, against Leishmania amazonensis: Antiproliferative, Biochemical, and Ultrastructural Effects

(2008) J. C. Fernandes Rodrigues et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Different reaction mechanisms for cis- and trans-prenyltransferases

(2008) Yen-Pin Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spin distribution of the H-cluster in the Hox–CO state of the [FeFe] hydrogenase from Desulfovibrio desulfuricans: HYSCORE and ENDOR study of 14N and 13C nuclear interactions

(2008) Alexey Silakov et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Structure of (E)-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

(2008) Ingo Rekittke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From Molecular Fossils of Bacterial Hopanoids to the Formation of Isoprene Units: Discovery and Elucidation of the Methylerythritol Phosphate Pathway

(2008) Michel Rohmer   LIPIDS

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH

Terpenoid biomaterials

(2008) Jörg Bohlmann et al.   PLANT JOURNAL

A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence

(2008) C.-I Liu et al.   SCIENCE