Sickle Cell Disease: Role of Oxidative Stress and Antioxidant Therapy

Complement activation in sickle cell disease: Dependence on cell density, hemolysis and modulation by hydroxyurea therapy

(2020) Lubka T. Roumenina et al.   AMERICAN JOURNAL OF HEMATOLOGY

The role of myeloperoxidase (MPO) in biomolecule modification, chronic inflammation and disease.

(2020) Michael Davies Davies et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress assessment in sickle cell anemia patients treated with hydroxyurea

(2020) Cristiane O. Renó et al.   ANNALS OF HEMATOLOGY

Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease

(2020) Panae Noomuna et al.   BRITISH JOURNAL OF HAEMATOLOGY

Correlation of lipid peroxidation and nitric oxide metabolites, trace elements, and antioxidant enzymes in patients with sickle cell disease

(2020) Charles Antwi‐Boasiako et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease

(2020) Michael Brad Strader et al.   Scientific Reports

Correction: Curcumin attenuates iron accumulation and oxidative stress in the liver and spleen of chronic iron-overloaded rats

(2020) Farid A. Badria et al.   PLoS One

Red blood cells microparticles are associated with hemolysis markers and may contribute to clinical events among sickle cell disease patients

(2019) Oladele Simeon Olatunya et al.   ANNALS OF HEMATOLOGY

Impaired antioxidant capacity causes a disruption of metabolic homeostasis in sickle erythrocytes

(2019) Nayara Alves Chaves et al.   FREE RADICAL BIOLOGY AND MEDICINE

Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents

(2019) Jon A. Detterich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood

(2019) Anub M. Thomas et al.   JOURNAL OF IMMUNOLOGY

Modification of proteins by reactive lipid oxidation products and biochemical effects of lipoxidation

(2019) Corinne M. Spickett et al.   Essays in Biochemistry

Serum haptoglobin and hemopexin levels are depleted in pediatric sickle cell disease patients

(2018) Rayra Pereira Santiago et al.   BLOOD CELLS MOLECULES AND DISEASES

Oxidative stress and phosphatidylserine exposure in red cells from patients with sickle cell anaemia

(2018) Anke Hannemann et al.   BRITISH JOURNAL OF HAEMATOLOGY

Oxidative stress, antioxidant capacity, biomolecule damage, and inflammation symptoms of sickle cell disease in children

(2018) Sebaranjan Biswal et al.   Hematology

A Phase 3 Trial of l-Glutamine in Sickle Cell Disease

(2018) Yutaka Niihara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease

(2018) Xiaohong Liu et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

(2018) Rafael Radi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sickle cell disease

(2018) Gregory J. Kato et al.   Nature Reviews Disease Primers

Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease

(2018) Ayla Yalamanoglu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Differences in heme and hemopexin content in lipoproteins from patients with sickle cell disease

(2018) Felipe Vendrame et al.   Journal of Clinical Lipidology

Pathophysiology of Sickle Cell Disease

(2018) Prithu Sundd et al.   Annual Review of Pathology-Mechanisms of Disease

Advances in the Treatment of Sickle Cell Disease

(2018) Sargam Kapoor et al.   MAYO CLINIC PROCEEDINGS

Soluble receptor for advanced glycation end products as a vasculopathy biomarker in sickle cell disease

(2018) Nesma Ahmed Safwat et al.   PEDIATRIC RESEARCH

Intravascular hemolysis and the pathophysiology of sickle cell disease

(2017) Gregory J. Kato et al.   JOURNAL OF CLINICAL INVESTIGATION

Sickle cell disease

(2017) Russell E Ware et al.   LANCET

Sickle Cell Disease

(2017) Frédéric B. Piel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sickle cell disease in the older adult

(2017) Mya S. Thein et al.   PATHOLOGY

Individual variability in response to a single sickling event for normal, sickle cell, and sickle trait erythrocytes

(2017) Michael Tarasev et al.   Translational Research

The Heme Connection: Linking Erythrocytes and Macrophage Biology

(2017) Md Zahidul Alam et al.   Frontiers in Immunology

The Mechanism of Proinflammatory HDL Generation in Sickle Cell Disease Is Linked to Cell-Free Hemoglobin via Haptoglobin

(2016) Xiang Ji et al.   PLoS One

Blood Antioxidant Parameters in Sickle Cell Anemia Patients in Steady State

(2016) Luísa Lauermann Lazzaretti et al.   JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION

Evolution of sickle cell disease from a life-threatening disease of children to a chronic disease of adults: The last 40 years

(2015) Shruti Chaturvedi et al.   AMERICAN JOURNAL OF HEMATOLOGY

Vasculopathy and pulmonary hypertension in sickle cell disease

(2015) Karin P. Potoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Special delivery: microparticles convey heme

(2015) G. M. Vercellotti   BLOOD

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

(2015) S. M. Camus et al.   BLOOD

Covalent modification of DNA by α, β-unsaturated aldehydes derived from lipid peroxidation: Recent progress and challenges

(2015) X. Wei et al.   FREE RADICAL RESEARCH

Dietary  -3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease

(2015) B. T. Kalish et al.   HAEMATOLOGICA

Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)

(2015) Tigist Kassa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble RAGEs — Prospects for treating & tracking metabolic and inflammatory disease

(2015) Ann Marie Schmidt   VASCULAR PHARMACOLOGY

Dietary  -3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease

(2015) B. T. Kalish et al.   HAEMATOLOGICA

The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions

(2015) Joseph M. Rifkind et al.   Frontiers in Physiology

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Curcumin Attenuates Iron Accumulation and Oxidative Stress in the Liver and Spleen of Chronic Iron-Overloaded Rats

(2015) Farid A. Badria et al.   PLoS One

Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation

(2014) N. Cardenes et al.   BLOOD

Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD

(2014) A. O. Awojoodu et al.   BLOOD

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Hemoglobin S Polymerization and Red Cell Membrane Changes

(2014) Frans A. Kuypers   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging

(2014) Joy G. Mohanty et al.   Frontiers in Physiology

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

(2013) A. George et al.   BLOOD

Sickle hemoglobin disturbs normal coupling among erythrocyte O2 content, glycolysis, and antioxidant capacity

(2013) S. C. Rogers et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease

(2013) Viachaslau M. Barodka et al.   BLOOD CELLS MOLECULES AND DISEASES

Asymmetric dimethylarginine levels in children with sickle cell disease and its correlation to tricuspid regurgitant jet velocity

(2013) Mohamed El-Shanshory et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Oxidative stress in sickle cell disease: An overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies

(2013) Danilo Grunig Humberto Silva et al.   FREE RADICAL BIOLOGY AND MEDICINE

The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: Insights into the potential of various iron therapies to induce oxidative and nitrosative stress

(2013) Taija S. Koskenkorva-Frank et al.   FREE RADICAL BIOLOGY AND MEDICINE

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

(2013) G. Vistoli et al.   FREE RADICAL RESEARCH

Thalassemic erythrocytes release microparticles loaded with hemichromes by redox activation of p72Syk kinase

(2013) E. Ferru et al.   HAEMATOLOGICA

2D DIGE based proteomics study of erythrocyte cytosol in sickle cell disease: Altered proteostasis and oxidative stress

(2013) Avik Basu et al.   PROTEOMICS

Genetic modifiers of sickle cell disease

(2012) Martin H. Steinberg et al.   AMERICAN JOURNAL OF HEMATOLOGY

N-acetylcysteine reduces oxidative stress in sickle cell patients

(2012) Erfan Nur et al.   ANNALS OF HEMATOLOGY

Principles in Redox Signaling: From Chemistry to Functional Significance

(2012) Alberto Bindoli et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability

(2012) Ying-Hao Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

L-arginine as an adjuvant drug in the treatment of sickle cell anaemia

(2012) Darcielle Bruna Dias Elias et al.   BRITISH JOURNAL OF HAEMATOLOGY

Advanced Glycation End Products and Diabetic Cardiovascular Disease

(2012) Anand Prasad et al.   Cardiology in Review

Natural antiband 3 antibodies in patients with sickle cell disease

(2012) Rinaldo Villaescusa et al.   COMPTES RENDUS BIOLOGIES

Advanced glycation end products and neurodegenerative diseases: Mechanisms and perspective

(2012) Jinlong Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A global perspective on sickle cell disease

(2012) Banu Aygun et al.   PEDIATRIC BLOOD & CANCER

Reactive carbonyl species: Their production from lipid peroxides, action in environmental stress, and the detoxification mechanism

(2012) Jun’ichi Mano   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Oxidative stress and antioxidant capacity in sickle cell anaemia patients receiving different treatments and medications for different periods of time

(2011) Edis Belini Junior et al.   ANNALS OF HEMATOLOGY

S-Glutathionylation: From Molecular Mechanisms to Health Outcomes

(2011) Ying Xiong et al.   ANTIOXIDANTS & REDOX SIGNALING

Assessment of oxidative stress in patients with sickle cell disease: The glutathione system and the oxidant–antioxidant status

(2011) Anna Gizi et al.   BLOOD CELLS MOLECULES AND DISEASES

Biomarkers in sickle cell disease

(2011) David C. Rees et al.   BRITISH JOURNAL OF HAEMATOLOGY

Role of oxidative stress in the pathogenesis of sickle cell disease

(2011) Erica N. Chirico et al.   IUBMB LIFE

Pathophysiology of sickle cell disease is mirrored by the red blood cell metabolome

(2010) D. Darghouth et al.   BLOOD

Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patients

(2010) Erfan Nur et al.   BRITISH JOURNAL OF HAEMATOLOGY

Haptoglobin: Old protein with new functions

(2010) Abdu I. Alayash   CLINICA CHIMICA ACTA

Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease

(2010) Iryna Rusanova et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Peroxiredoxin-2 expression is increased in β-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress

(2010) Alessandro Matte et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aggregation of mononuclear and red blood cells through an  4 1-Lu/basal cell adhesion molecule interaction in sickle cell disease

(2010) V. Chaar et al.   HAEMATOLOGICA

Sickle cell anemia and vascular dysfunction: The nitric oxide connection

(2010) Idowu Akinsheye et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Novel Function of Advanced Glycation End Products in Regulation of MMP-9 Production

(2010) Fan Zhang et al.   JOURNAL OF SURGICAL RESEARCH

Sickle-cell disease

(2010) David C Rees et al.   LANCET

Hydroxyurea-Induced Expression of Glutathione Peroxidase 1 in Red Blood Cells of Individuals with Sickle Cell Anemia

(2009) Chun-Seok Cho et al.   ANTIOXIDANTS & REDOX SIGNALING

Evolutionary Aspects of Hemoglobin Scavengers

(2009) Krzysztof B. Wicher et al.   ANTIOXIDANTS & REDOX SIGNALING

Hemoglobin and Heme Scavenger Receptors

(2009) Marianne Jensby Nielsen et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme Degradation and Vascular Injury

(2009) John D. Belcher et al.   ANTIOXIDANTS & REDOX SIGNALING

Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death

(2009) Gregory J. Kato et al.   BRITISH JOURNAL OF HAEMATOLOGY

Tetrahydrobiopterin, superoxide, and vascular dysfunction

(2009) Jeannette Vásquez-Vivar   FREE RADICAL BIOLOGY AND MEDICINE

Lipid peroxidation: Physiological levels and dual biological effects

(2009) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells

(2009) Gabriela Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: Role of asymmetric dimethylarginine

(2009) Shruti Sharma et al.   VASCULAR PHARMACOLOGY

Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress

(2008) Dhananjay K. Kaul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Peroxiredoxin 2 and Peroxide Metabolism in the Erythrocyte

(2008) Felicia M. Low et al.   ANTIOXIDANTS & REDOX SIGNALING

Red cell membrane: past, present, and future

(2008) N. Mohandas et al.   BLOOD

Heme degradation and oxidative stress in murine models for hemoglobinopathies: Thalassemia, sickle cell disease and hemoglobin C disease

(2008) Enika Nagababu et al.   BLOOD CELLS MOLECULES AND DISEASES

Association of asymmetric dimethylarginine with sickle cell disease-related pulmonary hypertension

(2008) P. P. Landburg et al.   HAEMATOLOGICA

Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin

(2008) Ivan Azarov et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Chronic Hyper-Hemolysis in Sickle Cell Anemia: Association of Vascular Complications and Mortality with Less Frequent Vasoocclusive Pain

(2008) James G. Taylor et al.   PLoS One

Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts

(2008) Ashutosh Lal et al.   REDOX REPORT

Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients

(2008) Bin Bao et al.   Translational Research