Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)

Vasculopathy and pulmonary hypertension in sickle cell disease

(2015) Karin P. Potoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease

(2015) Narendranath Reddy Chintagari et al.   BLOOD CELLS MOLECULES AND DISEASES

Sickle Cell Hemoglobin with Mutation at αHis-50 Has Improved Solubility

(2015) Ming F. Tam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erythroid DAMPs drive inflammation in SCD

(2014) M. T. Gladwin et al.   BLOOD

Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation

(2014) N. Cardenes et al.   BLOOD

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin

(2014) Todd L. Mollan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ischemia-reperfusion Injury in Sickle Cell Anemia

(2014) Robert P. Hebbel   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Post-translational Transformation of Methionine to Aspartate Is Catalyzed by Heme Iron and Driven by Peroxide

(2014) Michael Brad Strader et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood substitutes: why haven’t we been more successful?

(2014) Abdu I. Alayash   TRENDS IN BIOTECHNOLOGY

Structure of fully liganded Hb ζ2β2strapped in a tense conformation

(2013) Martin K. Safo et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine β145

(2013) Chris E. Cooper et al.   ANTIOXIDANTS & REDOX SIGNALING

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

(2013) A. George et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein Carbonylation, Mitochondrial Dysfunction, and Insulin Resistance

(2013) Brigitte I. Frohnert et al.   Advances in Nutrition

Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity

(2013) Seema Bansal et al.   Redox Biology

Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy

(2012) Ashlee N. Higdon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

α-Hemoglobin Stabilizing Protein (AHSP) Markedly Decreases the Redox Potential and Reactivity of α-Subunits of Human HbA with Hydrogen Peroxide

(2012) Todd L. Mollan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Isolated Hb Providence β82Asn and β82Asp Fractions Are More Stable than Native HbA0under Oxidative Stress Conditions

(2011) Bindu Abraham et al.   BIOCHEMISTRY

Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: Implications in dopamine cytotoxicity and pathogenesis of Parkinson's disease

(2011) Sirsendu Jana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Assessing bioenergetic function in response to oxidative stress by metabolic profiling

(2011) Brian P. Dranka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Translocation of Heme Oxygenase-1 to Mitochondria Is a Novel Cytoprotective Mechanism against Non-steroidal Anti-inflammatory Drug-induced Mitochondrial Oxidative Stress, Apoptosis, and Gastric Mucosal Injury

(2011) Samik Bindu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemoglobins S and C Interfere with Actin Remodeling in Plasmodium falciparum-Infected Erythrocytes

(2011) M. Cyrklaff et al.   SCIENCE

Reconstructing sickle cell disease: A data-based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence-based medicine

(2010) Robert P. Hebbel   AMERICAN JOURNAL OF HEMATOLOGY

The Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms

(2010) Brandon J. Reeder   ANTIOXIDANTS & REDOX SIGNALING

Quantitative Mass Spectrometry Defines an Oxidative Hotspot in Hemoglobin that is Specifically Protected by Haptoglobin

(2010) Tatiana Pimenova et al.   JOURNAL OF PROTEOME RESEARCH

Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

(2009) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells

(2009) Gabriela Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

Tyrosine Residues as Redox Cofactors in Human Hemoglobin

(2008) Brandon J. Reeder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY