Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

(2014) Yujin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

(2013) D. Manwani et al.   BLOOD

Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis

(2013) Anthony O. Awojoodu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoxetine Induced Suicidal Erythrocyte Death

(2013) Kashif Jilani et al.   Toxins

Shaping the landscape: Metabolic regulation of S1P gradients

(2012) Ana Olivera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Accumulated Bending Energy Elicits Neutral Sphingomyelinase Activity in Human Red Blood Cells

(2012) David J. López et al.   BIOPHYSICAL JOURNAL

Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease

(2012) S. M. Camus et al.   BLOOD

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release

(2012) K. Golan et al.   BLOOD

Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release

(2012) Jean-Philip Truman et al.   IMMUNOLOGY

Cardiovascular Abnormalities in Sickle Cell Disease

(2012) Mark T. Gladwin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Monocytes from sickle cell disease patients induce differential pulmonary endothelial gene expression via activation of NF-κB signaling pathway

(2012) Surinder Safaya et al.   MOLECULAR IMMUNOLOGY

Circulating platelet and erythrocyte microparticles in young children and adolescents with sickle cell disease: Relation to cardiovascular complications

(2012) Azza Abdel Gawad Tantawy et al.   PLATELETS

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure

(2012) S Dinkla et al.   Cell Death & Disease

Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium

(2011) R. Zennadi et al.   BLOOD

Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands

(2011) C Bardelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models

(2011) M. Opreanu et al.   DIABETES

Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells

(2011) Alvaro Yogi et al.   HYPERTENSION

Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells

(2010) A. Weigert et al.   BLOOD

Microparticles

(2010) Sebastian F. Mause et al.   CIRCULATION RESEARCH

Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes

(2010) Ruijuan Xu et al.   FASEB JOURNAL

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

(2010) Masaru Ishii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation

(2010) Kevin A. Harvey et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hypoxia Mediated Release of Endothelial Microparticles and Increased Association of S100A12 with Circulating Neutrophils

(2010) Rebecca V. Vince et al.   Oxidative Medicine and Cellular Longevity

Acid Sphingomyelinase Inhibitors Normalize Pulmonary Ceramide and Inflammation in Cystic Fibrosis

(2009) Katrin Anne Becker et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sphingosine 1-Phosphate Receptor Signaling

(2009) Hugh Rosen et al.   Annual Review of Biochemistry

Roles and regulation of secretory and lysosomal acid sphingomyelinase

(2009) Russell W. Jenkins et al.   CELLULAR SIGNALLING

Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium

(2008) R. Zennadi et al.   BLOOD

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

(2008) Rebecca L. Shaner et al.   JOURNAL OF LIPID RESEARCH

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Increased procoagulant cell-derived microparticles (C-MP) in splenectomized patients with ITP

(2008) V. Fontana et al.   THROMBOSIS RESEARCH