Ketogenic diets, mitochondria, and neurological diseases

Ketone body metabolism and cardiovascular disease

(2013) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats

(2013) Dominic P. D'Agostino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy

(2013) Manuela Mazzuferi et al.   ANNALS OF NEUROLOGY

Energy Failure

(2013) Divya Pathak et al.   ANNALS OF NEUROLOGY

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

A decade of the modified Atkins diet (2003–2013): Results, insights, and future directions

(2013) Eric H. Kossoff et al.   EPILEPSY & BEHAVIOR

Mitochondrial involvement and oxidative stress in temporal lobe epilepsy

(2013) Shane Rowley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Traumatic Brain Injury Pathophysiology and Treatments: Early, Intermediate, and Late Phases Post-Injury

(2013) Hanna Algattas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ketogenic Diets and Pain

(2013) Susan A. Masino et al.   JOURNAL OF CHILD NEUROLOGY

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy

(2013) Mussie G. Hadera et al.   JOURNAL OF NEUROCHEMISTRY

 -Hydroxybutyrate Modulates N-Type Calcium Channels in Rat Sympathetic Neurons by Acting as an Agonist for the G-Protein-Coupled Receptor FFA3

(2013) Y.-J. Won et al.   JOURNAL OF NEUROSCIENCE

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy

(2013) Howard T Chang et al.   Nutrition & Metabolism

Ketogenic Diet Improves Core Symptoms of Autism in BTBR Mice

(2013) David N. Ruskin et al.   PLoS One

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity?

(2013) Adina T. Michael-Titus et al.   TRENDS IN NEUROSCIENCES

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases

(2013) Michael Wong   Biomedical Journal

Metabolic and Neuropsychiatric Effects of Calorie Restriction and Sirtuins

(2012) Sergiy Libert et al.   Annual Review of Physiology

Mitochondrial Ca2+ and neurodegeneration

(2012) Tito Calì et al.   CELL CALCIUM

Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease

(2012) Mark P. Mattson   Cell Metabolism

Brain response to calorie restriction

(2012) Salvatore Fusco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetics and epilepsy

(2012) Avtar Roopra et al.   EPILEPSIA

Why are antiepileptic drugs used for nonepileptic conditions?

(2012) Meir Bialer   EPILEPSIA

Harnessing the power of metabolism for seizure prevention: Focus on dietary treatments

(2012) Adam L. Hartman et al.   EPILEPSY & BEHAVIOR

A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in mice

(2012) Shireesh Srivastava et al.   IUBMB LIFE

Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death

(2012) S. Kovac et al.   JOURNAL OF CELL SCIENCE

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures

(2012) Alfredo Giménez-Cassina et al.   NEURON

Energy depletion in seizures: Anaplerosis as a strategy for future therapies

(2012) Stjepana Kovac et al.   NEUROPHARMACOLOGY

The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma

(2012) Mohammed G. Abdelwahab et al.   PLoS One

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

The ketogenic diet: metabolic influences on brain excitability and epilepsy

(2012) Andrew Lutas et al.   TRENDS IN NEUROSCIENCES

The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders

(2012) Carl E. Stafstrom et al.   Frontiers in Pharmacology

Diet induced epigenetic changes and their implications for health

(2011) J. A. McKay et al.   Acta Physiologica

Energy, evolution, and human diseases: an overview

(2011) Jesse Roth et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The ketogenic and related diets in adolescents and adults-A review

(2011) Natasha E. Payne et al.   EPILEPSIA

The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway

(2011) Sharon S. McDaniel et al.   EPILEPSIA

Purines and neuronal excitability: Links to the ketogenic diet

(2011) S.A. Masino et al.   EPILEPSY RESEARCH

Modulation of oxidative stress and mitochondrial function by the ketogenic diet

(2011) Julie Milder et al.   EPILEPSY RESEARCH

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

(2011) Susan A. Masino et al.   JOURNAL OF CLINICAL INVESTIGATION

Single KATP Channel Opening in Response to Action Potential Firing in Mouse Dentate Granule Neurons

(2011) G. R. Tanner et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial response to controlled nutrition in health and disease

(2011) Manuel Schiff et al.   NUTRITION REVIEWS

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Metabolic management of brain cancer

(2010) Thomas N. Seyfried et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metabolic Networks of Longevity

(2010) Riekelt H. Houtkooper et al.   CELL

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

(2010) Tadahiro Shimazu et al.   Cell Metabolism

KAT(ching) Metabolism by the Tail: Insight into the Links between Lysine Acetyltransferases and Metabolism

(2010) Brittany N. Albaugh  et al.   CHEMBIOCHEM

Polyunsaturated fatty acids and epilepsy

(2010) Ameer Y. Taha et al.   EPILEPSIA

Ketogenic diet treatment in adults with refractory epilepsy

(2010) Pavel Klein et al.   EPILEPSY & BEHAVIOR

Mitochondrial quality control and neurological disease: an emerging connection

(2010) Inês Pimenta de Castro et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy?

(2010) Simon Waldbaum et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Dietary ketosis enhances memory in mild cognitive impairment

(2010) Robert Krikorian et al.   NEUROBIOLOGY OF AGING

Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models

(2010) Sarah Willis et al.   NEUROBIOLOGY OF DISEASE

Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet

(2010) Julie B. Milder et al.   NEUROBIOLOGY OF DISEASE

Metabolic Control of Vesicular Glutamate Transport and Release

(2010) Narinobu Juge et al.   NEURON

The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma

(2010) Phillip Stafford et al.   Nutrition & Metabolism

Cancer as a metabolic disease

(2010) Thomas N Seyfried et al.   Nutrition & Metabolism

Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models

(2009) Carl E. Stafstrom et al.   ANNALS OF NEUROLOGY

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats

(2009) Zhi-Gang Hu et al.   BRAIN INJURY

The ketogenic diet and epilepsy

(2009) Do Young Kim et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy

(2009) David A. Muzykewicz et al.   EPILEPSIA

Mitochondria, oxidative stress, and temporal lobe epilepsy

(2009) Simon Waldbaum et al.   EPILEPSY RESEARCH

Ketogenic Diets: An Update for Child Neurologists

(2009) Eric H. Kossoff et al.   JOURNAL OF CHILD NEUROLOGY

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

Ketogenic diets: Evidence for short- and long-term efficacy

(2009) Eric H. Kossoff et al.   Neurotherapeutics

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

(2009) Samuel T Henderson et al.   Nutrition & Metabolism

Reduced Pain and Inflammation in Juvenile and Adult Rats Fed a Ketogenic Diet

(2009) David N. Ruskin et al.   PLoS One

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Cysteine-based regulation of the CUL3 adaptor protein Keap1

(2009) Konjeti R. Sekhar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The on-off switches of the mitochondrial uncoupling proteins

(2009) Vian Azzu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus

(2008) Xin Yu et al.   BRAIN RESEARCH

The ketogenic diet: Uses in epilepsy and other neurologic illnesses

(2008) Kristin W. Barañano et al.   Current Treatment Options in Neurology

Potential consequences of altered neurogenesis on learning and memory in the epileptic brain

(2008) Jan Martin Wojtowicz   EPILEPSIA

Efficacy of the ketogenic diet in the 6-Hz seizure test

(2008) Adam L. Hartman et al.   EPILEPSIA

Integration of adult generated neurons during epileptogenesis

(2008) Chuan-Sheng Zhao et al.   EPILEPSIA

The ketogenic diet-update on recent clinical trials

(2008) J. Helen Cross et al.   EPILEPSIA

The Modified Atkins Diet

(2008) Eric H. Kossoff et al.   EPILEPSIA

Fenofibrate, a peroxisome proliferator-activated receptor-α agonist, exerts anticonvulsive properties

(2008) Natacha Porta et al.   EPILEPSIA

A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy

(2008) Elizabeth G. Neal et al.   EPILEPSIA

Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group

(2008) Eric H. Kossoff et al.   EPILEPSIA

A randomized trial of polyunsaturated fatty acids for refractory epilepsy

(2008) Edward Bromfield et al.   EPILEPSY & BEHAVIOR

The ketogenic diet increases mitochondrial glutathione levels

(2008) Stuart G. Jarrett et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative impairment of hippocampal long-term potentiation involves activation of protein phosphatase 2A and is prevented by ketone bodies

(2008) Marwan Maalouf et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Fasting is neuroprotective following traumatic brain injury

(2008) Laurie M. Davis et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

(2008) Elizabeth G Neal et al.   LANCET NEUROLOGY

The PPARγ agonist FMOC-l-leucine protects both mature and immature brain

(2007) Pierre Maurois et al.   BIOMEDICINE & PHARMACOTHERAPY

When do seizures usually improve with the ketogenic diet?

(2007) Eric H. Kossoff et al.   EPILEPSIA

A Prospective Study of the Modified Atkins Diet for Intractable Epilepsy in Adults

(2007) Eric H. Kossoff et al.   EPILEPSIA