Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, Irisin

Extracellular vesicles secreted from mouse muscle cells suppress osteoclast formation: Roles of mitochondrial energy metabolism

(2020) Yoshimasa Takafuji et al.   BONE

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Vascular Smooth Muscle Cell-Derived Exosomal MicroRNAs Regulate Endothelial Cell Migration Under PDGF Stimulation

(2020) Jeongyeon Heo et al.   Cells

Cardiomyocyte‐derived exosomal microRNA‐92a mediates post‐ischemic myofibroblast activation both in vitro and ex vivo

(2020) Xujun Wang et al.   ESC Heart Failure

Cardiac Tissue Remodeling in Healthy Aging: The Road to Pathology

(2020) Evan Tracy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins

(2020) Phyoe Kyawe Myint et al.   Diagnostic Pathology

New insights into the cellular activities of Fndc5/Irisin and its signaling pathways

(2020) Farzaneh Rabiee et al.   Cell and Bioscience

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

(2020) Yasuo Oguri et al.   CELL

Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis

(2020) Binglin Yue et al.   CELL PROLIFERATION

Stem cell homing: From physiology to therapeutics

(2020) Jane L. Liesveld et al.   STEM CELLS

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

(2020) Eben G Estell et al.   eLife

MicroRNA-196a-5p in Extracellular Vesicles Secreted from Myoblasts Suppresses Osteoclast-like Cell Formation in Mouse Cells

(2020) Yoshimasa Takafuji et al.   CALCIFIED TISSUE INTERNATIONAL

Inhibition of αvβ3 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles

(2020) Wanessa F. Altei et al.   Cell Communication and Signaling

Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin

(2020) Eun Jeong Park et al.   Frontiers in Cell and Developmental Biology

Effect of Exercise on Fatty Acid Metabolism and Adipokine Secretion in Adipose Tissue

(2019) Adriana Mika et al.   Frontiers in Physiology

Endothelial cell–cardiomyocyte crosstalk in heart development and disease

(2019) Andrea Colliva et al.   JOURNAL OF PHYSIOLOGY-LONDON

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

(2019) Sadanand Fulzele et al.   Aging-US

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Skeletal muscle derived exosomes regulate endothelial cell functions via reactive oxygen species activated NF‐κB signaling

(2019) Yaohui Nie et al.   EXPERIMENTAL PHYSIOLOGY

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish

(2019) Hannah M. Isles et al.   Frontiers in Immunology

Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases

(2019) Paulina Korta et al.   Medicina-Lithuania

Muscle-Derived Extracellular Vesicles Influence Motor Neuron Regeneration Accuracy

(2019) Roger D. Madison et al.   NEUROSCIENCE

Skeletal Muscle-Released Extracellular Vesicles: State of the Art

(2019) Sophie Rome et al.   Frontiers in Physiology

Cardiomyocyte-Derived Exosomes: Biological Functions and Potential Therapeutic Implications

(2019) Hui Yu et al.   Frontiers in Physiology

Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling

(2019) Fernando de la Cuesta et al.   Cell Communication and Signaling

Exosomes in Sepsis and Inflammatory Tissue Injury.

(2019) Eun Jeong Park et al.   CURRENT PHARMACEUTICAL DESIGN

Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin αVβ5 receptor

(2019) Jianbin Bi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Collective cancer invasion forms an integrin-dependent radioresistant niche

(2019) Anna Haeger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart

(2019) Wanling Xuan et al.   Stem Cells International

Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion

(2019) Marco B. Morelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circulatory exosomal miRNA following intense exercise is unrelated to muscle and plasma miRNA abundances

(2018) Randall F. D'Souza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exosomes from C2C12 myoblasts enhance osteogenic differentiation of MC3T3-E1 pre-osteoblasts by delivering miR-27a-3p

(2018) Qian Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms

(2018) Chunmei Li et al.   BMC CANCER

MicroRNA-1246 inhibits cell invasion and epithelial mesenchymal transition process by targeting CXCR4 in lung cancer cells

(2018) Xiaohui Xu et al.   Cancer Biomarkers

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

(2018) Martin Whitham et al.   Cell Metabolism

CD150 high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

(2018) Yuichi Hirata et al.   Cell Stem Cell

Exosomes and extracellular vesicles: the path forward

(2018) Philip D. Stahl et al.   Essays in Biochemistry

Serum irisin associates with breast cancer to spinal metastasis

(2018) Zheng-ping Zhang et al.   MEDICINE

FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity

(2018) Xiao-Qing Xiong et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The harsh microenvironment in infarcted heart accelerates transplanted bone marrow mesenchymal stem cells injury: the role of injured cardiomyocytes-derived exosomes

(2018) Ming Hu et al.   Cell Death & Disease

MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress.

(2018) Jie Yuan et al.   Theranostics

Roles of Exosome-Like Vesicles Released from Inflammatory C2C12 Myotubes: Regulation of Myocyte Differentiation and Myokine Expression

(2018) Sujin Kim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Prostate cancer sheds the αvβ3 integrin in vivo through exosomes

(2018) Shiv Ram Krishn et al.   MATRIX BIOLOGY

Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases

(2018) Luana G. Leal et al.   Frontiers in Physiology

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2018) Hyeonwoo Kim et al.   CELL

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

(2017) Agnieszka Irena Mazur-Bialy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis

(2017) Bin Zheng et al.   MOLECULAR THERAPY

Irisin reverses the IL-6 induced epithelial-mesenchymal transition in osteosarcoma cell migration and invasion through the STAT3/Snail signaling pathway

(2017) Gang Kong et al.   ONCOLOGY REPORTS

Increased FNDC5/Irisin expression in human hepatocellular carcinoma

(2017) Melania Gaggini et al.   PEPTIDES

Crosstalk between adipokines and myokines in fat browning

(2016) A. Rodríguez et al.   Acta Physiologica

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice

(2016) Audrey Jalabert et al.   DIABETOLOGIA

Cardiac Extracellular Vesicles in Normal and Infarcted Heart

(2016) Dimitry Chistiakov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration

(2016) Ji Suk Choi et al.   JOURNAL OF CONTROLLED RELEASE

Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation

(2016) A. N. Kapustin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exosome-mediated Transfer of  v 3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype

(2016) A. Singh et al.   MOLECULAR CANCER RESEARCH

Reverse-topology membrane scission by the ESCRT proteins

(2016) Johannes Schöneberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Skeletal muscle Heat shock protein 60 increases after endurance training and induces peroxisome proliferator-activated receptor gamma coactivator 1 α1 expression

(2016) Rosario Barone et al.   Scientific Reports

Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes

(2015) Nahuel A. Garcia et al.   CARDIOVASCULAR RESEARCH

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

(2015) A. N. Kapustin et al.   CIRCULATION RESEARCH

MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial HypertensionNovelty and Significance

(2015) Lin Deng et al.   CIRCULATION RESEARCH

The αvβ6Integrin Is Transferred Intercellularly via Exosomes

(2015) Carmine Fedele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiosome mediated regulation of MMP9 in diabetic heart: role of mir29b and mir455 in exercise

(2015) Pankaj Chaturvedi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Resistance exercise induces a greater irisin response than endurance exercise

(2015) Yoshifumi Tsuchiya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Deep Proteomics of Mouse Skeletal Muscle Enables Quantitation of Protein Isoforms, Metabolic Pathways, and Transcription Factors

(2015) Atul S. Deshmukh et al.   MOLECULAR & CELLULAR PROTEOMICS

MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction

(2015) SAI WANG et al.   Molecular Medicine Reports

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells

(2015) Nahuel A. Garcia et al.   PLoS One

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Effects of the exercise-inducible myokine irisin on malignant and non-malignant breast epithelial cell behaviorin vitro

(2014) Nicholas P. Gannon et al.   INTERNATIONAL JOURNAL OF CANCER

Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells

(2014) Xiaohong Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues

(2014) Suleyman Aydin et al.   PEPTIDES

Proteomic Analysis of C2C12 Myoblast and Myotube Exosome-Like Vesicles: A New Paradigm for Myoblast-Myotube Cross Talk?

(2014) Alexis Forterre et al.   PLoS One

High-Intensity Exercise Causes Greater Irisin Response Compared with Low-Intensity Exercise under Similar Energy Consumption

(2014) Yoshifumi Tsuchiya et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Irisin Enhances Osteoblast DifferentiationIn Vitro

(2014) Graziana Colaianni et al.   International Journal of Endocrinology

Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles

(2013) Neta Regev-Rudzki et al.   CELL

Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation

(2013) Alexis Forterre et al.   CELL CYCLE

Macrophage-Derived Matrix Vesicles

(2013) Sophie E. P. New et al.   CIRCULATION RESEARCH

Contraction and AICAR Stimulate IL-6 Vesicle Depletion From Skeletal Muscle Fibers In Vivo

(2013) Hans P.M.M. Lauritzen et al.   DIABETES

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Neural Stem Cell Niches and Homing: Recruitment and Integration into Functional Tissues

(2013) T. Garzon-Muvdi et al.   ILAR JOURNAL

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway

(2013) W. M. Henne et al.   Cold Spring Harbor Perspectives in Biology

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications

(2013) Keitaro Hagiwara et al.   Drug Delivery and Translational Research

β7 integrin controls immunogenic and tolerogenic mucosal B cell responses

(2012) Angela Schippers et al.   CLINICAL IMMUNOLOGY

Metabolic Syndrome and Risk of Cancer: A systematic review and meta-analysis

(2012) K. Esposito et al.   DIABETES CARE

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

(2012) Y. Lee et al.   HUMAN MOLECULAR GENETICS

The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001

(2012) Rebecca E. De Angel et al.   MOLECULAR CARCINOGENESIS

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Exercise in the Metabolic Syndrome

(2012) Saeid Golbidi et al.   Oxidative Medicine and Cellular Longevity

Hsp20 Functions as a Novel Cardiokine in Promoting Angiogenesis via Activation of VEGFR2

(2012) Xiaowei Zhang et al.   PLoS One

Cardiomyocyte Microvesicles Contain DNA/RNA and Convey Biological Messages to Target Cells

(2012) Anders Waldenström et al.   PLoS One

Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells

(2012) Aysegul Ocal Sahin et al.   Cell Adhesion & Migration

Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines

(2012) Marcus M. Seldin et al.   Adipocyte

The growing challenge of obesity and cancer: an inflammatory issue

(2011) Alison E. Harvey et al.   Annals of the New York Academy of Sciences

The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

(2011) Mitsuhiro Yamada et al.   Cellular & Molecular Immunology

The emerging role of HSP20 as a multifunctional protective agent

(2011) H.V. Edwards et al.   CELLULAR SIGNALLING

Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization

(2011) Alexander N. Kapustin et al.   CIRCULATION RESEARCH

MiR-133a regulates collagen 1A1: Potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension

(2011) Giovanna Castoldi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Integrins in Cell Migration

(2011) A. Huttenlocher et al.   Cold Spring Harbor Perspectives in Biology

Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?

(2010) S. Viaud et al.   CANCER RESEARCH

Hold Me Tight

(2010) Monte S. Willis et al.   CIRCULATION

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

MicroRNA-320 EXPRESSION IN MYOCARDIAL MICROVASCULAR ENDOTHELIAL CELLS AND ITS RELATIONSHIP WITH INSULIN-LIKE GROWTH FACTOR-1 IN TYPE 2 DIABETIC RATS

(2008) XH Wang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

WHIM syndrome: congenital immune deficiency disease

(2008) Toshinao Kawai et al.   CURRENT OPINION IN HEMATOLOGY

Trafficking and function of the tetraspanin CD63

(2008) Maaike S. Pols et al.   EXPERIMENTAL CELL RESEARCH

Metabolic Responses to Reduced Daily Steps in Healthy Nonexercising Men

(2008)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ALIX-CHMP4 interactions in the human ESCRT pathway

(2008) J. McCullough et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA