TRIM8: Making the Right Decision between the Oncogene and Tumour Suppressor Role

TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours

(2017) Francesca Mastropasqua et al.   Molecular Cancer

TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3

(2017) Changming Zhang et al.   Molecular Oncology

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

miR-182 promotes tumor growth and increases chemoresistance of human anaplastic thyroid cancer by targeting tripartite motif 8

(2017) Yao Liu et al.   OncoTargets and Therapy

Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport

(2016) Subhas Mukherjee et al.   CANCER RESEARCH

Fish TRIM8 exerts antiviral roles through regulation of the proinflammatory factors and interferon signaling

(2016) Youhua Huang et al.   FISH & SHELLFISH IMMUNOLOGY

TRIMming p53’s anticancer activity

(2016) S Elabd et al.   ONCOGENE

TRIM8 regulates the chemoresistance of colorectal cancer in a p53-dependent manner

(2016) Mingli Ni et al.   Oncology Letters

STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia

(2016) Feng-Ting Liu et al.   Oncotarget

A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-κB regulates head and neck squamous cell carcinoma proliferation

(2016) Zhipeng Li et al.   Oncotarget

TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival

(2015) Lucia Micale et al.   BMC CANCER

Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma

(2015) Fei Wang et al.   Molecular Cancer

TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

(2015) Yu Chen et al.   Oncotarget

TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

(2015) Mariano Francesco Caratozzolo et al.   Oncotarget

Human Brat Ortholog TRIM3 Is a Tumor Suppressor That Regulates Asymmetric Cell Division in Glioblastoma

(2014) G. Chen et al.   CANCER RESEARCH

TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting

(2014) A. Herrmann et al.   CANCER RESEARCH

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins

(2014) Gijs A. Versteeg et al.   CYTOKINE & GROWTH FACTOR REVIEWS

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

(2014) Zhicheng Zhou et al.   GASTROENTEROLOGY

miR-106b-25/miR-17-92clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma

(2014) Weiqi Tan   WORLD JOURNAL OF GASTROENTEROLOGY

Knockdown of Oct4 and Nanog expression inhibits the stemness of pancreatic cancer cells

(2013) Yuhua Lu et al.   CANCER LETTERS

Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling

(2013) A. Schroeder et al.   CANCER RESEARCH

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease

(2013) E Mogilyansky et al.   CELL DEATH AND DIFFERENTIATION

Integrated molecular analysis of clear-cell renal cell carcinoma

(2013) Yusuke Sato et al.   NATURE GENETICS

The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis

(2013) X Lu et al.   ONCOGENE

TRIM8 modulates p53 activity to dictate cell cycle arrest

(2012) Mariano Francesco Caratozzolo et al.   CELL CYCLE

The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes

(2012) R Bomben et al.   LEUKEMIA

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

NANOG modulates stemness in human colorectal cancer

(2012) J Zhang et al.   ONCOGENE

Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-κB Pathway

(2012) Dhanendra Tomar et al.   PLoS One

Ubiquitylation of p53 by the APC/C inhibitor Trim39

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional interactions between ubiquitin E2 enzymes and TRIM proteins

(2011) Luisa M. Napolitano et al.   BIOCHEMICAL JOURNAL

Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3

(2011) Olga A. Guryanova et al.   CANCER CELL

NF-κB in immunobiology

(2011) Matthew S Hayden et al.   CELL RESEARCH

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

(2011) Taro Kawai et al.   EMBO Molecular Medicine

Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2

(2011) Hae Mi Joo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation

(2011) Luisa M. Napolitano et al.   IUBMB LIFE

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation

(2011) Yunjiao Wang et al.   JOURNAL OF THEORETICAL BIOLOGY

Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination

(2011) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of p53 in stem cells

(2011) Giuseppina Bonizzi et al.   TRENDS IN MOLECULAR MEDICINE

PIAS3 expression in human gastric carcinoma and its adjacent non-tumor tissues

(2011) Liang-ming Liu et al.   Clinics and Research in Hepatology and Gastroenterology

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

(2010) F. Okumura et al.   JOURNAL OF CELL SCIENCE

The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions

(2010) Z. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

SUMOylation of the GTPase Rac1 is required for optimal cell migration

(2010) Sonia Castillo-Lluva et al.   NATURE CELL BIOLOGY

SUMO E3 ligase activity of TRIM proteins

(2010) Y Chu et al.   ONCOGENE

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Roles of NF-κB in health and disease: mechanisms and therapeutic potential

(2009) Ee Tsin Wong et al.   CLINICAL SCIENCE

Stat3 activation is required for the growth of U87 cell-derived tumours in mice

(2009) Atreyi Dasgupta et al.   EUROPEAN JOURNAL OF CANCER

Keeping an eye on retinoblastoma control of human embryonic stem cells

(2009) Jamie F. Conklin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The miR-17-92 Cluster is Over Expressed in and Has an Oncogenic Effect on Renal Cell Carcinoma

(2009) Tsz-fung F. Chow et al.   JOURNAL OF UROLOGY

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

Human TRIM Gene Expression in Response to Interferons

(2009) Laetitia Carthagena et al.   PLoS One

Trim24 targets endogenous p53 for degradation

(2009) Kendra Allton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Loss of Protein Inhibitors of Activated STAT-3 Expression in Glioblastoma Multiforme Tumors: Implications for STAT-3 Activation and Gene Expression

(2008) E. C. Brantley et al.   CLINICAL CANCER RESEARCH

Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells

(2008) Ricardo Rajsbaum et al.   EUROPEAN JOURNAL OF IMMUNOLOGY