The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis

Vitamin D Deficiency Is Associated With Increased Risk of Non-alcoholic Steatohepatitis in Adults With Non-alcoholic Fatty Liver Disease: Possible Role for MAPK and NF-κB?

(2016) James E Nelson et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Hepatic Oncostatin M Receptor β Regulates Obesity-Induced Steatosis and Insulin Resistance

(2016) Pengcheng Luo et al.   AMERICAN JOURNAL OF PATHOLOGY

The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia

(2016) Daniel Okin et al.   CELL

Targeting TRAF3 signaling protects against hepatic ischemia/reperfusions injury

(2016) Junfei Hu et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

TAK1 regulates hepatic lipid homeostasis through SREBP

(2016) S Morioka et al.   ONCOGENE

Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling

(2016) Pi-Xiao Wang et al.   Nature Communications

The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

(2016) Yan-Xiao Ji et al.   Nature Communications

Effects of Moderate and Vigorous Exercise on Nonalcoholic Fatty Liver Disease

(2016) Hui-Jie Zhang et al.   JAMA Internal Medicine

Interferon Regulatory Factor Signalings in Cardiometabolic Diseases

(2015) Xiao-Jing Zhang et al.   HYPERTENSION

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

(2015) Szu-Wei Lee et al.   MOLECULAR CELL

CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis

(2014) Kyoung-Jin Oh et al.   BMB Reports

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

(2014) Sayaka Inokuchi-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice

(2014) Li-Hua Zhu et al.   JOURNAL OF HEPATOLOGY

Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signalling

(2014) Wei Liu et al.   Nature Communications

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-κB and activator protein-1

(2013) Xiaofang Huo et al.   GUT

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes

(2013) Andreas L. Birkenfeld et al.   HEPATOLOGY

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

From NAFLD in clinical practice to answers from guidelines

(2013) Fabio Nascimbeni et al.   JOURNAL OF HEPATOLOGY

TRIMmunity: The Roles of the TRIM E3-Ubiquitin Ligase Family in Innate Antiviral Immunity

(2013) Ricardo Rajsbaum et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol

(2012) Jiaquan Wu et al.   ACS Chemical Biology

Inactivation of the Deubiquitinase CYLD in Hepatocytes Causes Apoptosis, Inflammation, Fibrosis, and Cancer

(2012) Kostas Nikolaou et al.   CANCER CELL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

TRIM8 modulates p53 activity to dictate cell cycle arrest

(2012) Mariano Francesco Caratozzolo et al.   CELL CYCLE

Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-κB Pathway

(2012) Dhanendra Tomar et al.   PLoS One

Targeting of TAK1 in inflammatory disorders and cancer

(2012) Hiroaki Sakurai   TRENDS IN PHARMACOLOGICAL SCIENCES

Insulin signaling to hepatic lipid metabolism in health and disease

(2011) Karla F. Leavens et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Non-alcoholic fatty liver disease

(2011) Briohny W. Smith et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

TAK1: Another mesh in the NF-κB – JNK controlled network causing hepatocellular carcinoma

(2011) Florian R. Greten   JOURNAL OF HEPATOLOGY

Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination

(2011) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tripartite-motif proteins and innate immune regulation

(2010) Finlay W McNab et al.   CURRENT OPINION IN IMMUNOLOGY

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPKPathways

(2010) Dan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

(2010) F. Okumura et al.   JOURNAL OF CELL SCIENCE

Insulin resistance, inflammation, and non-alcoholic fatty liver disease

(2008) Herbert Tilg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM