Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization

Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide

(2020) Kyungjin Min et al.   STRUCTURE

The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting

(2020) Martine J. Smit et al.   Annual Review of Pharmacology and Toxicology

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication

(2020) Amos Fumagalli et al.   Nature Communications

Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling

(2020) Hemlata Dwivedi-Agnihotri et al.   Science Advances

CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2

(2020) Huong Thi Nguyen et al.   Cell and Bioscience

GPCR Signaling Regulation: The Role of GRKs and Arrestins

(2019) Vsevolod V. Gurevich et al.   Frontiers in Pharmacology

ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin

(2019) Friederike Saaber et al.   Cell Reports

Atypical Chemokine Receptors in Cardiovascular Disease

(2019) Selin Gencer et al.   THROMBOSIS AND HAEMOSTASIS

CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status

(2019) Amos Fumagalli et al.   MOLECULAR PHARMACOLOGY

The role of ACKR3 in breast, lung and brain cancer.

(2019) Maria Neves et al.   MOLECULAR PHARMACOLOGY

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub

(2019) Petronila Penela et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Arrestin‐independent constitutive endocytosis of GPR125/ADGRA3

(2019) Katja Spiess et al.   Annals of the New York Academy of Sciences

Genome Editing Provides New Insights into Receptor-Controlled Signalling Pathways

(2018) Graeme Milligan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

CXCR7 Targeting and Its Major Disease Relevance

(2018) Chuan Wang et al.   Frontiers in Pharmacology

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

(2018) Louis M. Luttrell et al.   Science Signaling

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

(2018) I. Adlere et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders

(2018) Jaana van Gastel et al.   Frontiers in Pharmacology

Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3–mediated chemokine scavenging

(2017) Nicolas Montpas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation

(2017) Punita Kumari et al.   MOLECULAR BIOLOGY OF THE CELL

Understanding the Differential Selectivity of Arrestins toward the Phosphorylation State of the Receptor

(2016) Ozge Sensoy et al.   ACS Chemical Neuroscience

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling

(2016) Elisa Alvarez-Curto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overview and potential unifying themes of the atypical chemokine receptor family

(2016) Alessandro Vacchini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography

(2016) Honggang Huang et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells

(2016) Raymond H. de Wit et al.   Oncotarget

Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response

(2016) Raffaella Bonecchi et al.   Frontiers in Immunology

A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate

(2015) Angélique Levoye et al.   Frontiers in Endocrinology

Imaging Ligand-Dependent Activation of CXCR7

(2015) Kathryn E. Luker et al.   NEOPLASIA

KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport

(2014) Malte Schmick et al.   CELL

The regulator of G protein signaling (RGS) domain of G protein–coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function

(2014) Hua Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

CXCR7 Controls Competition for Recruitment of β-Arrestin 2 in Cells Expressing Both CXCR4 and CXCR7

(2014) Nathaniel L. Coggins et al.   PLoS One

Hierarchical Organization of Multi-Site Phosphorylation at the CXCR4 C Terminus

(2013) Wiebke Mueller et al.   PLoS One

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

(2012) Frauke Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer

(2012) Martin Klammer et al.   MOLECULAR & CELLULAR PROTEOMICS

Ubiquitination of CXCR7 Controls Receptor Trafficking

(2012) Meritxell Canals et al.   PLoS One

Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET

(2012) Tien-Hung Lan et al.   TRAFFIC

Atypical chemokine receptors

(2011) Maria Helena Ulvmar et al.   EXPERIMENTAL CELL RESEARCH

Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

(2011) Xuanzhi Zhan et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

(2011) D. M. Thal et al.   MOLECULAR PHARMACOLOGY

Internalization Dissociates β2-Adrenergic Receptors

(2011) Tien-Hung Lan et al.   PLoS One

Distinct and Shared Roles of β-Arrestin-1 and β-Arrestin-2 on the Regulation of C3a Receptor Signaling in Human Mast Cells

(2011) Arpana Vibhuti et al.   PLoS One

Phosphorylation Barcoding as a Mechanism of Directing GPCR Signaling

(2011) S. B. Liggett   Science Signaling

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

(2010) Xueqing Sun et al.   CANCER AND METASTASIS REVIEWS

Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands

(2010) K E Luker et al.   ONCOGENE

Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells

(2009) Haiyu Li et al.   BMC CANCER

Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands

(2009) B. A. Zabel et al.   JOURNAL OF IMMUNOLOGY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

(2008) Bijan Boldajipour et al.   CELL

A Novel Protein Kinase A-independent, β-Arrestin-1-dependent Signaling Pathway for p38 Mitogen-activated Protein Kinase Activation by β2-Adrenergic Receptors

(2008) Kaizheng Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY