Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3–mediated chemokine scavenging

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of ligand interaction with atypical chemokine receptor 3

(2017) Martin Gustavsson et al.   Nature Communications

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor

(2016) Xufan Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12

(2016) Besma Benredjem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

(2016) K. Eichel et al.   NATURE CELL BIOLOGY

Functional competence of a partially engaged GPCR–β-arrestin complex

(2016) Punita Kumari et al.   Nature Communications

An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15

(2015) Françoise Bachelerie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Biased GsVersusGqProteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network

(2015) Louise Valentin-Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations

(2015) Jérôme Cabana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased Signaling at Chemokine Receptors

(2015) Jenny Corbisier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets

(2015) Nathan Karin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Imaging Ligand-Dependent Activation of CXCR7

(2015) Kathryn E. Luker et al.   NEOPLASIA

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis

(2014) Yaniv Zohar et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular control of δ-opioid receptor signalling

(2014) Gustavo Fenalti et al.   NATURE

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Crystal structure of a common GPCR-binding interface for G protein and arrestin

(2014) Michal Szczepek et al.   Nature Communications

Biased and G Protein-Independent Signaling of Chemokine Receptors

(2014) Anne Steen et al.   Frontiers in Immunology

Generation and Dynamics of an Endogenous, Self-Generated Signaling Gradient across a Migrating Tissue

(2013) Gayatri Venkiteswaran et al.   CELL

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

(2013) Sudarshan Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Agonist Affinity at the  -Opioid Receptor Induced by Prolonged Agonist Exposure

(2013) W. T. Birdsong et al.   JOURNAL OF NEUROSCIENCE

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach

(2013) Ka Young Chung et al.   PLoS One

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

Dual-Duty Active Site

(2013) V. Vinson   Science Signaling

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

 -arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation

(2012) H. Mahabaleshwar et al.   DEVELOPMENT

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

(2012) Frauke Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitination of CXCR7 Controls Receptor Trafficking

(2012) Meritxell Canals et al.   PLoS One

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

(2012) R. Rahmeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

(2012) Tony Warne et al.   STRUCTURE

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

(2011) Ana C Magalhaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

(2011) Lillian Cruz-Orengo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

(2011) X. Deupi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Peptidomimetic CXCR4 Antagonist TC14012 Recruits β-Arrestin to CXCR7

(2010) Stéphanie Gravel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different Effects of the Different Natural CC Chemokine Receptor 2b Ligands on  -Arrestin Recruitment, G i Signaling, and Receptor Internalization

(2010) Y. A. Berchiche et al.   MOLECULAR PHARMACOLOGY

CXCR7 Functions as a Scavenger for CXCL12 and CXCL11

(2010) Ulrike Naumann et al.   PLoS One

Biased Signaling of the Angiotensin II Type 1 Receptor Can Be Mediated through Distinct Mechanisms

(2010) Marie Mi Bonde et al.   PLoS One

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

(2009) I. Kalatskaya et al.   MOLECULAR PHARMACOLOGY

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

(2008) Bijan Boldajipour et al.   CELL

Multiple Roles for the C-terminal Tail of the Chemokine Scavenger D6

(2008) Clare V. McCulloch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Analysis of the Conserved Asp2.50 and ERY Motif Reveals Signaling Bias of the Urotensin II Receptor

(2008) C. D. Proulx et al.   MOLECULAR PHARMACOLOGY

β-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction

(2007) K DeFea   BRITISH JOURNAL OF PHARMACOLOGY