Overview and potential unifying themes of the atypical chemokine receptor family

Pioglitazone Suppresses CXCR7 Expression To Inhibit Human Macrophage Chemotaxis through Peroxisome Proliferator-Activated Receptor γ

(2015) Duo Zhao et al.   BIOCHEMISTRY

An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15

(2015) Françoise Bachelerie et al.   BRITISH JOURNAL OF PHARMACOLOGY

CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice

(2015) Beth Lucas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Specificity of arrestin subtypes in regulating airway smooth muscle G protein–coupled receptor signaling and function

(2015) Tonio Pera et al.   FASEB JOURNAL

MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis

(2015) Setareh Alampour-Rajabi et al.   FASEB JOURNAL

Biased Signaling at Chemokine Receptors

(2015) Jenny Corbisier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet surface expression of stromal cell-derived factor-1 receptors CXCR4 and CXCR7 is associated with clinical outcomes in patients with coronary artery disease

(2015) D. Rath et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives

(2015) Lukas Pawig et al.   Frontiers in Immunology

Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus

(2015) Jianwu Bai et al.   PLoS One

Imaging Ligand-Dependent Activation of CXCR7

(2015) Kathryn E. Luker et al.   NEOPLASIA

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells

(2014) Rebecca A Pelekanos et al.   BMC CELL BIOLOGY

DARC shuttles inflammatory chemokines across the blood–brain barrier during autoimmune central nervous system inflammation

(2014) Carsten Minten et al.   BRAIN

Macrophage Migration Inhibitory Factor Limits Activation-Induced Apoptosis of Platelets via CXCR7-Dependent Akt Signaling

(2014) Madhumita Chatterjee et al.   CIRCULATION RESEARCH

Decoy Receptor CXCR7 Modulates Adrenomedullin-Mediated Cardiac and Lymphatic Vascular Development

(2014) Klara R. Klein et al.   DEVELOPMENTAL CELL

Intermediate expression of CCRL1 reveals novel subpopulations of medullary thymic epithelial cells that emerge in the postnatal thymus

(2014) Ana R. Ribeiro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CCRL1 marks heterogeneity in cortical and medullary thymic epithelial cells

(2014) Izumi Ohigashi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Chemokine Receptor CXCR3 Is Degraded following Internalization and Is Replenished at the Cell Surface by De Novo Synthesis of Receptor

(2014) A. Meiser et al.   JOURNAL OF IMMUNOLOGY

Hemopoietic Cell Expression of the Chemokine Decoy Receptor D6 Is Dynamic and Regulated by GATA1

(2014) C. S. McKimmie et al.   JOURNAL OF IMMUNOLOGY

Atypical Chemokine Receptor ACKR2 Mediates Chemokine Scavenging by Primary Human Trophoblasts and Can Regulate Fetal Growth, Placental Structure, and Neonatal Mortality in Mice

(2014) Pek Joo Teoh et al.   JOURNAL OF IMMUNOLOGY

CXCL1 Inhibits Airway Smooth Muscle Cell Migration through the Decoy Receptor Duffy Antigen Receptor for Chemokines

(2014) L. A. Al-Alwan et al.   JOURNAL OF IMMUNOLOGY

Endothelial Cell-Derived Chemerin Promotes Dendritic Cell Transmigration

(2014) S. Gonzalvo-Feo et al.   JOURNAL OF IMMUNOLOGY

Characterization of Conventional and Atypical Receptors for the Chemokine CCL2 on Mouse Leukocytes

(2014) L. B. Ford et al.   JOURNAL OF IMMUNOLOGY

Chemokine decoy receptor D6 mimicking trap (D6MT) prevents allosensitization and immune rejection in murine corneal allograft model

(2014) Wungrak Choi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

New nomenclature for atypical chemokine receptors

(2014) Françoise Bachelerie et al.   NATURE IMMUNOLOGY

CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12

(2014) Rita de Cássia Carvalho Melo et al.   PLoS One

CXCR7 Controls Competition for Recruitment of β-Arrestin 2 in Cells Expressing Both CXCR4 and CXCR7

(2014) Nathaniel L. Coggins et al.   PLoS One

CXCR7 signaling induced epithelial–mesenchymal transition by AKT and ERK pathways in epithelial ovarian carcinomas

(2014) Hao Yu et al.   TUMOR BIOLOGY

Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers

(2014) Jessica L. Williams et al.   Frontiers in Cellular Neuroscience

Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid

(2014) Leah A. Marquez-Curtis et al.   Stem Cells International

Atypical chemokine receptors: from silence to sound

(2013) Cinzia Cancellieri et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

An analysis of the function and expression of D6 on lymphatic endothelial cells

(2013) C. S. McKimmie et al.   BLOOD

Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5)

(2013) A Steen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Complementary Populations of Human Adipose CD34+ Progenitor Cells Promote Growth, Angiogenesis, and Metastasis of Breast Cancer

(2013) S. Orecchioni et al.   CANCER RESEARCH

Modulation of Circadian Glucocorticoid Oscillation via Adrenal Opioid-CXCR7 Signaling Alters Emotional Behavior

(2013) Yuichi Ikeda et al.   CELL

Generation and Dynamics of an Endogenous, Self-Generated Signaling Gradient across a Migrating Tissue

(2013) Gayatri Venkiteswaran et al.   CELL

Expression of the Atypical Chemokine Receptor D6 in Human Alveolar Macrophages in COPD

(2013) Erica Bazzan et al.   CHEST

A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system

(2013) Iain Comerford et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CCRL2, a fringe member of the atypical chemoattractant receptor family

(2013) Annalisa Del Prete et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCR7 influences the migration of B cells during maturation

(2013) Marie-Luise Humpert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels

(2013) Robert D. Berahovich et al.   IMMUNOLOGY

Global gene expression changes in BV2 microglial cell line during rabies virus infection

(2013) Pingsen Zhao et al.   INFECTION GENETICS AND EVOLUTION

β-Arrestin Recruitment and G Protein Signaling by the Atypical Human Chemokine Decoy Receptor CCX-CKR

(2013) Anne O. Watts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chemokine Receptor CCR1 Is Constitutively Active, Which Leads to G Protein-independent, β-Arrestin-mediated Internalization

(2013) C. Taylor Gilliland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

(2013) Sudarshan Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Autonomous Regulation of Neutrophil Migration by the D6 Chemokine Decoy Receptor

(2013) A. Rot et al.   JOURNAL OF IMMUNOLOGY

Directional tissue migration through a self-generated chemokine gradient

(2013) Erika Donà et al.   NATURE

 -Arrestin-Dependent Activation of the Cofilin Pathway Is Required for the Scavenging Activity of the Atypical Chemokine Receptor D6

(2013) E. M. Borroni et al.   Science Signaling

Arrest Functions of the MIF Ligand/Receptor Axes in Atherogenesis

(2013) Sabine Tillmann et al.   Frontiers in Immunology

Elevated Expression of the Chemokine-Scavenging Receptor D6 Is Associated with Impaired Lesion Development in Psoriasis

(2012) Mark D. Singh et al.   AMERICAN JOURNAL OF PATHOLOGY

CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity

(2012) M. D. Bunting et al.   BLOOD

Correlation between Duffy blood group phenotype and breast cancer incidence

(2012) Xiao-feng Liu et al.   BMC CANCER

Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR

(2012) J Vinet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12

(2012) Anup Kumar Singh et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

The biochemistry and biology of the atypical chemokine receptors

(2012) G.J. Graham et al.   IMMUNOLOGY LETTERS

Carboxy-terminus of CXCR7 regulates receptor localization and function

(2012) Paramita Ray et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Impact of Duffy antigen receptor for chemokine gene expression on mandibular bone density in menopausal women

(2012) W. Świątkowski et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

(2012) Frauke Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration

(2012) K. Schaeuble et al.   JOURNAL OF CELL SCIENCE

Chemerin Regulates NK Cell Accumulation and Endothelial Cell Morphogenesis in the Decidua during Early Pregnancy

(2012) Claudia Carlino et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Expression, Regulation, and Function of Atypical Chemerin Receptor CCRL2 on Endothelial Cells

(2012) J. Monnier et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors

(2012) M. E. Hamby et al.   JOURNAL OF NEUROSCIENCE

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

CXCR7 mediates SDF1-induced melanocyte migration

(2012) Eunkyung Lee et al.   Pigment Cell & Melanoma Research

Ubiquitination of CXCR7 Controls Receptor Trafficking

(2012) Meritxell Canals et al.   PLoS One

Regenerative capacity of adult cortical thymic epithelial cells

(2012) I. Rode et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complementary methods provide evidence for the expression of CXCR7 on human B cells

(2012) Marie-Luise Humpert et al.   PROTEOMICS

Evolutionary Analysis of Functional Divergence among Chemokine Receptors, Decoy Receptors, and Viral Receptors

(2012) Hiromi Daiyasu et al.   Frontiers in Microbiology

Endogenous Ligand Bias by Chemokines: Implications at the Front Lines of Infection and Leukocyte Trafficking

(2012) David A. Zidar   Endocrine Metabolic & Immune Disorders-Drug Targets

An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis

(2011) V. Codullo et al.   ANNALS OF THE RHEUMATIC DISEASES

The CXCR7 chemokine receptor promotes B-cell retention in the splenic marginal zone and serves as a sink for CXCL12

(2011) H. Wang et al.   BLOOD

Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice

(2011) C. A. H. Hansell et al.   BLOOD

D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion

(2011) K. M. Lee et al.   BLOOD

CCL2 binding is CCR2 independent in primary adult human astrocytes

(2011) A. Fouillet et al.   BRAIN RESEARCH

The presumed atypical chemokine receptor CXCR7 signals through Gi/o proteins in primary rodent astrocytes and human glioma cells

(2011) Veysel Ödemis et al.   GLIA

CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration

(2011) Fabien M. Décaillot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

(2011) Lillian Cruz-Orengo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR7 and syndecan-4 are potential receptors for CXCL12 in human cytotrophoblasts

(2011) A. Schanz et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Duffy Antigen Receptor for Chemokines Mediates Chemokine Endocytosis through a Macropinocytosis-Like Process in Endothelial Cells

(2011) Yani Zhao et al.   PLoS One

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pathogenic role of CXCR7 in rheumatoid arthritis

(2010) Kaori Watanabe et al.   ARTHRITIS AND RHEUMATISM

Astrocytes modulate the chemokine network in a pathogen-specific manner

(2010) Clive S. McKimmie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nonredundant role of CCRL2 in lung dendritic cell trafficking

(2010) K. Otero et al.   BLOOD

Chemokine-like receptor 1 (CMKLR1) and chemokine (C–C motif) receptor-like 2 (CCRL2); Two multifunctional receptors with unusual properties

(2010) Teizo Yoshimura et al.   EXPERIMENTAL CELL RESEARCH

Expression of chemokine decoy receptors and their ligands at the porcine maternal-fetal interface

(2010) Jocelyn M Wessels et al.   IMMUNOLOGY AND CELL BIOLOGY

CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells

(2010) V. Odemis et al.   JOURNAL OF CELL SCIENCE

Chemokine Scavenger D6 Is Expressed by Trophoblasts and Aids the Survival of Mouse Embryos Transferred into Allogeneic Recipients

(2010) J. Madigan et al.   JOURNAL OF IMMUNOLOGY

CXCR7 Protein Is Not Expressed on Human or Mouse Leukocytes

(2010) R. D. Berahovich et al.   JOURNAL OF IMMUNOLOGY

The chemokine receptor CXCR7 is expressed on lymphatic endothelial cells during renal allograft rejection

(2010) Matthias A. Neusser et al.   KIDNEY INTERNATIONAL

Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell chronic lymphocytic leukemia

(2010) Julie Catusse et al.   Molecular Cancer

Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands

(2010) K E Luker et al.   ONCOGENE

CXCR7 Functions as a Scavenger for CXCL12 and CXCL11

(2010) Ulrike Naumann et al.   PLoS One

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

(2009) A. Levoye et al.   BLOOD

Chemokines and chemokine receptors: an overview

(2009) Raffaella Bonecchi   Frontiers in Bioscience-Landmark

CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B

(2009) Marion Leick et al.   IMMUNOLOGY

RecognitionVersusAdaptive Up-regulation and Degradation of CC Chemokines by the Chemokine Decoy Receptor D6 Are Determined by Their N-terminal Sequence

(2009) Benedetta Savino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation

(2008) R. Bonecchi et al.   BLOOD

Imaging chemokine receptor dimerization with firefly luciferase complementation

(2008) Kathryn E. Luker et al.   FASEB JOURNAL

Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice

(2008) Han Gerrits et al.   GENESIS

Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner

(2008) Tanja N. Hartmann et al.   IMMUNOLOGY

Multiple Roles for the C-terminal Tail of the Chemokine Scavenger D6

(2008) Clare V. McCulloch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Expression of RDC1/CXCR7 in the Human Placenta

(2008) Vishwas Tripathi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Mast cell–expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis

(2008) Brian A. Zabel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells

(2008) Tanja Nicole Hartmann et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CXCR7, CXCR4 and CXCL12: An eccentric trio?

(2008) Marcus Thelen et al.   JOURNAL OF NEUROIMMUNOLOGY

The Duffy Antigen/Receptor for Chemokines Exists in an Oligomeric Form in Living Cells and Functionally Antagonizes CCR5 Signaling through Hetero-Oligomerization

(2008) A. Chakera et al.   MOLECULAR PHARMACOLOGY

How chemokines invite leukocytes to dance

(2008) Marcus Thelen et al.   NATURE IMMUNOLOGY

The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity

(2008) Monika Pruenster et al.   NATURE IMMUNOLOGY

Early immune response followingSalmonella entericasubspeciesentericaserovar Typhimurium infection in porcine jejunal gut loops

(2008) François Meurens et al.   VETERINARY RESEARCH