Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

(2020) Dean P. Staus et al.   NATURE

Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G protein–coupled receptors

(2020) Mithu Baidya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine in the lariat loop of arrestins does not serve as phosphate sensor

(2020) Sergey A. Vishnivetskiy et al.   JOURNAL OF NEUROCHEMISTRY

Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor

(2020) Yang Lee et al.   NATURE

GPCRmd uncovers the dynamics of the 3D-GPCRome

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Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms

(2019) Eshan Ghosh et al.   Cell Reports

A complex structure of arrestin-2 bound to a G protein-coupled receptor

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Catalytic activation of β-arrestin by GPCRs

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Molecular mechanism of GPCR-mediated arrestin activation

(2018) Naomi R. Latorraca et al.   NATURE

Arrestins as rheostats of GPCR signalling

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Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

(2018) Louis M. Luttrell et al.   Science Signaling

Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation

(2017) Punita Kumari et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model

(2017) Zhao Yang et al.   MOLECULAR PHARMACOLOGY

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Structural Insights into GPCR–β-Arrestin Interaction and Signaling

(2017) Ravi Ranjan et al.   TRENDS IN CELL BIOLOGY

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

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β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

(2016) K. Eichel et al.   NATURE CELL BIOLOGY

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Visualizing GPCR ‘Megaplexes’ Which Enable Sustained Intracellular Signaling

(2016) Fiona H. Marshall   TRENDS IN BIOCHEMICAL SCIENCES

Functional competence of a partially engaged GPCR–β-arrestin complex

(2016) Punita Kumari et al.   Nature Communications

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Emerging structural insights into biased GPCR signaling

(2014) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking

(2013) Dong Soo Kang et al.   CURRENT OPINION IN CELL BIOLOGY

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ACEMD: Accelerating Biomolecular Dynamics in the Microsecond Time Scale

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Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

(2008) Andrew B. Tobin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES