GPCR Signaling Regulation: The Role of GRKs and Arrestins

Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs

(2018) Whitney M. Cleghorn et al.   CELLULAR SIGNALLING

Different mode of arrestin-3 binding at the human Y 1 and Y 2 receptor

(2018) Lizzy Wanka et al.   CELLULAR SIGNALLING

The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation

(2018) Thomas F. Pack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gi- and Gs-coupled GPCRs show different modes of G-protein binding

(2018) Ned Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

Arrestins: structural disorder creates rich functionality

(2018) Vsevolod V. Gurevich et al.   Protein & Cell

Enhanced Mutant Compensates for Defects in Rhodopsin Phosphorylation in the Presence of Endogenous Arrestin-1

(2018) Srimal Samaranayake et al.   Frontiers in Molecular Neuroscience

Estrogen Regulation of GRK2 Inactivates Kappa Opioid Receptor Signaling Mediating Analgesia, But Not Aversion

(2018) Antony D. Abraham et al.   JOURNAL OF NEUROSCIENCE

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

(2018) Louis M. Luttrell et al.   Science Signaling

Arrestins and G proteins in cellular signaling: The coin has two sides

(2018) Vsevolod V. Gurevich et al.   Science Signaling

Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

(2018) Nicole A. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRK5 – A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders

(2018) Jhana O. Hendrickx et al.   Frontiers in Pharmacology

Cleavage of arrestin-3 by caspases attenuates cell death by precluding arrestin-dependent JNK activation

(2018) Seunghyi Kook et al.   CELLULAR SIGNALLING

Molecular Mechanisms of GPCR Signaling: A Structural Perspective

(2017) Vsevolod Gurevich et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation

(2017) Punita Kumari et al.   MOLECULAR BIOLOGY OF THE CELL

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

(2017) Yi-Lynn Liang et al.   NATURE

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

(2017) Yan Zhang et al.   NATURE

The Diverse Roles of Arrestin Scaffolds in G Protein–Coupled Receptor Signaling

(2017) Yuri K. Peterson et al.   PHARMACOLOGICAL REVIEWS

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

Mechanistic insights into GPCR–G protein interactions

(2016) Jacob P Mahoney et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling

(2016) Elisa Alvarez-Curto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

“Canonical and non-canonical actions of GRK5 in the heart”

(2016) Christopher J. Traynham et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Organization and functions of mGlu and GABAB receptor complexes

(2016) Jean-Philippe Pin et al.   NATURE

Functional competence of a partially engaged GPCR–β-arrestin complex

(2016) Punita Kumari et al.   Nature Communications

Peptide mini-scaffold facilitates JNK3 activation in cells

(2016) Xuanzhi Zhan et al.   Scientific Reports

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)

(2015) Lingyong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrestins regulate cell spreading and motility via focal adhesion dynamics

(2015) Whitney M. Cleghorn et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

How MAP kinase modules function as robust, yet adaptable, circuits

(2014) Tianhai Tian et al.   CELL CYCLE

Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes

(2014) Luis E. Gimenez et al.   CELLULAR SIGNALLING

GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity

(2014) Jonathan E. Hullmann et al.   CIRCULATION RESEARCH

Identification of Receptor Binding-induced Conformational Changes in Non-visual Arrestins

(2014) Ya Zhuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a common GPCR-binding interface for G protein and arrestin

(2014) Michal Szczepek et al.   Nature Communications

Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death

(2013) S Kook et al.   CELL DEATH AND DIFFERENTIATION

Arrestin-3 Binds c-Jun N-terminal Kinase 1 (JNK1) and JNK2 and Facilitates the Activation of These Ubiquitous JNK Isoforms in Cells via Scaffolding

(2013) Seunghyi Kook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

(2013) Jessica I. Gold et al.   PLoS One

Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina

(2013) Hormoz Moaven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRK2 Inhibition in Heart Failure: Something Old, Something New

(2012) Anastasios Lymperopoulos et al.   CURRENT PHARMACEUTICAL DESIGN

Role of Receptor-attached Phosphates in Binding of Visual and Non-visual Arrestins to G Protein-coupled Receptors

(2012) Luis E. Gimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manipulation of Very Few Receptor Discriminator Residues Greatly Enhances Receptor Specificity of Non-visual Arrestins

(2012) Luis E. Gimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silent Scaffolds

(2012) Maya Breitman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin Ligase Parkin Promotes Mdm2–Arrestin Interaction but Inhibits Arrestin Ubiquitination

(2011) M. Rafiuddin Ahmed et al.   BIOCHEMISTRY

A Single Mutation in Arrestin-2 Prevents ERK1/2 Activation by Reducing c-Raf1 Binding

(2011) Sergio Coffa et al.   BIOCHEMISTRY

Nonvisual Arrestins Function as Simple Scaffolds Assembling the MKK4–JNK3α2 Signaling Complex

(2011) Xuanzhi Zhan et al.   BIOCHEMISTRY

Identification of Arrestin-3-specific Residues Necessary for JNK3 Kinase Activation

(2011) Jungwon Seo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

(2011) Eugenia V. Gurevich et al.   PHARMACOLOGY & THERAPEUTICS

Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase

(2010) Adi Raveh et al.   CELL

Enhanced Arrestin Facilitates Recovery and Protects Rods Lacking Rhodopsin Phosphorylation

(2009) Xiufeng Song et al.   CURRENT BIOLOGY

Phosphorylation-independent Regulation of Metabotropic Glutamate Receptor 5 Desensitization and Internalization by G Protein-coupled Receptor Kinase 2 in Neurons

(2009) Fabiola M. Ribeiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEK1 Binds Directly to βArrestin1, Influencing Both Its Phosphorylation by ERK and the Timing of Its Isoprenaline-stimulated Internalization

(2009) Dong Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Arrestin α-Helix I in Receptor Binding

(2009) Sergey A. Vishnivetskiy et al.   JOURNAL OF MOLECULAR BIOLOGY

Role for the Regulator of G-Protein Signaling Homology Domain of G Protein-Coupled Receptor Kinases 5 and 6 in  2-Adrenergic Receptor and Rhodopsin Phosphorylation

(2009) F. Baameur et al.   MOLECULAR PHARMACOLOGY

How Does Arrestin Assemble MAPKs into a Signaling Complex?

(2008) Xiufeng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

(2008) J. S. Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY