Inducible Pluripotent Stem Cells as a Potential Cure for Diabetes

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells

(2020) Suman Bose et al.   Nature Biomedical Engineering

118-OR: HLA Matching and Clinical Outcomes in Islet Transplantation

(2020) VIRGINIA FUENMAYOR et al.   DIABETES

Role of the PD-1/PD-L1 Dyad in the Maintenance of Pancreatic Immune Tolerance for Prevention of Type 1 Diabetes

(2020) Marika Falcone et al.   Frontiers in Endocrinology

State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018

(2019) Nicole C. Foster et al.   Diabetes Technology & Therapeutics

Biomaterials: Foreign Bodies or Tuners for the Immune Response?

(2019) Erminia Mariani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy

(2019) Esther Latres et al.   Cell Metabolism

Generation of hypoimmunogenic human pluripotent stem cells

(2019) Xiao Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced pancreatic polypeptide response is associated with early alteration of glycemic control in chronic pancreatitis

(2019) Mohsin Aslam et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model

(2018) Antonio Bruni et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Improved outcomes of islet autotransplant after total pancreatectomy by combined blockade of IL-1β and TNFα

(2018) B. Naziruddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Insulin-producing Cells from Adult Human Bone Marrow Mesenchymal Stromal Cells Could Control Chemically Induced Diabetes in Dogs

(2018) Mahmoud M. Gabr et al.   CELL TRANSPLANTATION

Clinical islet transplantation

(2018) Andrew R. Pepper et al.   Current Opinion in Organ Transplantation

Initial Clinical Evaluation of VC-01TM Combination Product—A Stem Cell–Derived Islet Replacement for Type 1 Diabetes (T1D)

(2018) ROBERT R. HENRY et al.   DIABETES

Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents

(2018) Na Li et al.   Cell Death & Disease

Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis

(2018) Eleni Bekiari et al.   BMJ-British Medical Journal

Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis

(2018) Eleni Bekiari et al.   BMJ-British Medical Journal

Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques

(2018) Matthew A. Bochenek et al.   Nature Biomedical Engineering

Standardizing CAR-T therapy: Getting it scaled up

(2018) Xiaofeng Dai et al.   BIOTECHNOLOGY ADVANCES

Linking a cell-division gene and a suicide gene to define and improve cell therapy safety

(2018) Qin Liang et al.   NATURE

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

Bioengineering of an Intraabdominal Endocrine Pancreas

(2017) David A. Baidal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Islet Transplantation Provides Superior Glycemic Control With Less Hypoglycemia Compared With Continuous Subcutaneous Insulin Infusion or Multiple Daily Insulin Injections

(2017) Deborah Jane Holmes-Walker et al.   TRANSPLANTATION

Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)

(2017)   BMJ-British Medical Journal

Effect of Wnt Signaling on the Differentiation of Islet β-Cells from Adipose-Derived Stem Cells

(2017) Hefei Wang et al.   Biomed Research International

Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)

(2017)   BMJ-British Medical Journal

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

(2017) Andrew R. Pepper et al.   Stem Cell Reports

Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes

(2017) Kelen C. R. Malmegrim et al.   Frontiers in Immunology

Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation

(2016) J-R Chen et al.   CELL DEATH AND DIFFERENTIATION

Induced Pluripotent Stem Cells Meet Genome Editing

(2016) Dirk Hockemeyer et al.   Cell Stem Cell

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

(2016) Camillo Ricordi et al.   DIABETES

Variability of Insulin Requirements Over 12 Weeks of Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes

(2016) Yue Ruan et al.   DIABETES CARE

Diabetes Device Use in Adults With Type 1 Diabetes: Barriers to Uptake and Potential Intervention Targets

(2016) Molly L. Tanenbaum et al.   DIABETES CARE

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

A novel redox-active metalloporphyrin reduces reactive oxygen species and inflammatory markers but does not improve marginal mass engraftment in a murine donation after circulatory death islet transplantation model

(2016) Antonio Bruni et al.   Islets

Efficient generation of functional pancreatic β-cells from human induced pluripotent stem cells

(2016) Shigeharu G. Yabe et al.   Journal of Diabetes

Clinical manufacturing of CAR T cells: foundation of a promising therapy

(2016) Xiuyan Wang et al.   Molecular Therapy-Oncolytics

Clinical Benefit of Islet Xenotransplantation for the Treatment of Type 1 Diabetes

(2016) Shinichi Matsumoto et al.   EBioMedicine

Long-Term Control of Diabetes in Immunosuppressed Nonhuman Primates (NHP) by the Transplantation of Adult Porcine Islets

(2015) J. S. Shin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Generation of Human Alloantigen-Specific Regulatory T Cells under Good Manufacturing Practice-Compliant Conditions for Cell Therapy

(2015) Mustapha Chera et al.   CELL TRANSPLANTATION

Risk Factors Associated With Severe Hypoglycemia in Older Adults With Type 1 Diabetes

(2015) Ruth S. Weinstock et al.   DIABETES CARE

Interleukin-10 gene transfer into insulin-producing β cells protects against diabetes in non-obese diabetic mice

(2015) AIJING XU et al.   Molecular Medicine Reports

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

HLA Class I Depleted hESC as a Source of Hypoimmunogenic Cells for Tissue Engineering Applications

(2015) Zaruhi Karabekian et al.   TISSUE ENGINEERING PART A

A 3D map of the islet routes throughout the healthy human pancreas

(2015) Constantin Ionescu-Tirgoviste et al.   Scientific Reports

Side effects of the calcineurin inhibitor, such as new-onset diabetes after kidney transplantation

(2014) Bernadett Borda et al.   ACTA PHYSIOLOGICA HUNGARICA

Pig-to-Monkey Islet Xenotransplantation Using Multi-Transgenic Pigs

(2014) R. Bottino et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Human Pluripotent Stem Cell Culture: Considerations for Maintenance, Expansion, and Therapeutics

(2014) Kevin G. Chen et al.   Cell Stem Cell

Prevention of acute liver allograft rejection by IL-10-engineered mesenchymal stem cells

(2014) J. Niu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Islet cell transplant and the incorporation of Tregs

(2014) Adam Krzystyniak et al.   Current Opinion in Organ Transplantation

Neural regulation of pancreatic islet cell mass and function

(2014) B. Thorens   DIABETES OBESITY & METABOLISM

Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection

(2014) Carolina Moore et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

(2014) Lin Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Porcine Islet Xenotransplantation Under Comprehensive Regulation

(2014) S. Matsumoto et al.   TRANSPLANTATION PROCEEDINGS

Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells

(2014) Dorothea Maetzel et al.   Stem Cell Reports

TGF-β Signaling Regulates Pancreatic β-Cell Proliferation through Control of Cell Cycle Regulator p27 Expression

(2013) Tomoyuki Suzuki et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Lentivirus IL-10 Gene Therapy Down-Regulates IL-17 and Attenuates Mouse Orthotopic Lung Allograft Rejection

(2013) S. Hirayama et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Attenuation of Donor-Reactive T Cells Allows Effective Control of Allograft Rejection Using Regulatory T Cell Therapy

(2013) K. Lee et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus

(2013) Hsin-Chieh Yeh et al.   ANNALS OF INTERNAL MEDICINE

Allogeneic cell therapy bioprocess economics and optimization: Single-use cell expansion technologies

(2013) Ana S. Simaria et al.   BIOTECHNOLOGY AND BIOENGINEERING

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

(2013) Yun Li et al.   Cell Stem Cell

To Be Immunogenic, or Not to Be: That’s the iPSC Question

(2013) Shin Kaneko et al.   Cell Stem Cell

Lack of Immune Response to Differentiated Cells Derived from Syngeneic Induced Pluripotent Stem Cells

(2013) Prajna Guha et al.   Cell Stem Cell

Transplantation of Xenogeneic Islets: Are We There Yet?

(2013) Philip J. O’Connell et al.   Current Diabetes Reports

Thyroid Hormone Promotes Postnatal Rat Pancreatic  -Cell Development and Glucose-Responsive Insulin Secretion Through MAFA

(2013) C. Aguayo-Mazzucato et al.   DIABETES

Randomized Trial of Infusion Set Function: Steel Versus Teflon

(2013) Parul J. Patel et al.   Diabetes Technology & Therapeutics

Nonmetabolic Complications of Continuous Subcutaneous Insulin Infusion: A Patient Survey

(2013) John C. Pickup et al.   Diabetes Technology & Therapeutics

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

HLA Engineering of Human Pluripotent Stem Cells

(2013) Laura Riolobos et al.   MOLECULAR THERAPY

Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

(2013) Ryoko Araki et al.   NATURE

Low Immunogenicity of Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Derived from Less Immunogenic Somatic Cells

(2013) Pengfei Liu et al.   PLoS One

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

Glucose-stimulated insulin secretion: A newer perspective

(2013) Mitsuhisa Komatsu et al.   Journal of Diabetes Investigation

A replacement for islet equivalents with improved reliability and validity

(2012) Han-Hung Huang et al.   ACTA DIABETOLOGICA

Potent Induction Immunotherapy Promotes Long-Term Insulin Independence After Islet Transplantation in Type 1 Diabetes

(2012) M. D. Bellin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

iPSC Disease Modeling

(2012) F. Soldner et al.   SCIENCE

Concise Review: The Evolution of human pluripotent stem cell culture: From feeder cells to synthetic coatings

(2012) L.G. Villa-Diaz et al.   STEM CELLS

Anakinra Potentiates the Protective Effects of Etanercept in Transplantation of Marginal Mass Human Islets in Immunodeficient Mice

(2011) M. McCall et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Engineered polymer-media interfaces for the long-term self-renewal of human embryonic stem cells

(2011) Elizabeth F. Irwin et al.   BIOMATERIALS

State of the Art of Clinical Islet Transplantation and Novel Protocols of Immunosuppression

(2011) A. M. James Shapiro   Current Diabetes Reports

Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment

(2011) Bo Nilsson et al.   Current Opinion in Organ Transplantation

The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo

(2011) A. M. Paterson et al.   JOURNAL OF IMMUNOLOGY

Combinatorial treatment of bone marrow stem cells and stromal cell-derived factor 1 improves glycemia and insulin production in diabetic mice

(2011) H. Cheng et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice

(2011) Michael McCall et al.   SURGERY

Reduced Progression of Diabetic Microvascular Complications With Islet Cell Transplantation Compared With Intensive Medical Therapy

(2011) David M. Thompson et al.   TRANSPLANTATION

Lentivirus-mediated gene transfer of interleukin 10 to the ovine and human cornea

(2010) Douglas G Parker et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Noggin, Retinoids, and Fibroblast Growth Factor Regulate Hepatic or Pancreatic Fate of Human Embryonic Stem Cells

(2010) Josué Kunjom Mfopou et al.   GASTROENTEROLOGY

Comparison of Four Pancreatic Islet Implantation Sites

(2010) Hyoung-Il Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension

(2010) Debora Steiner et al.   NATURE BIOTECHNOLOGY

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

(2010) Sergey Rodin et al.   NATURE BIOTECHNOLOGY

Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium

(2010) Ruth Olmer et al.   Stem Cell Research

Up-scaling single cell-inoculated suspension culture of human embryonic stem cells

(2010) Harmeet Singh et al.   Stem Cell Research

Alginate Macroencapsulation of Pig Islets Allows Correction of Streptozotocin-Induced Diabetes in Primates up to 6 Months Without Immunosuppression

(2010) Denis Dufrane et al.   TRANSPLANTATION

Insulin-Heparin Infusions Peritransplant Substantially Improve Single-Donor Clinical Islet Transplant Success

(2010) Angela Koh et al.   TRANSPLANTATION

Neurogenin3: A master regulator of pancreatic islet differentiation and regeneration

(2010) J. Michael Rukstalis et al.   Islets

C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

(2009) Carlos E. B. Couri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion

(2009) Tina K. Thethi et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

(2009) Shuibing Chen et al.   Nature Chemical Biology

Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture

(2009) Christian Toso et al.   TRANSPLANT INTERNATIONAL

Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells

(2008) Takamichi Miyazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparison of the Portal Vein and Kidney Subcapsule as Sites for Primate Islet Autotransplantation

(2008) Amer Rajab et al.   CELL TRANSPLANTATION

The Caspase Selective Inhibitor EP1013 Augments Human Islet Graft Function and Longevity in Marginal Mass Islet Transplantation in Mice

(2008) J. A. Emamaullee et al.   DIABETES

Liraglutide, a Long-Acting Human Glucagon-Like Peptide 1 Analog, Improves Glucose Homeostasis in Marginal Mass Islet Transplantation in Mice

(2008) S. Merani et al.   ENDOCRINOLOGY

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Islet culture and counter-culture

(2008) Thierry Berney   TRANSPLANT INTERNATIONAL

A Multi-Year Analysis of Islet Transplantation Compared With Intensive Medical Therapy on Progression of Complications in Type 1 Diabetes

(2008) Garth L. Warnock et al.   TRANSPLANTATION