The Underlying Biology and Therapeutic Vulnerabilities of Leptomeningeal Metastases in Adult Solid Cancers

ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases

(2020) Priya Kumthekar et al.   CLINICAL CANCER RESEARCH

Proteomic Analysis of CSF from Patients with Leptomeningeal Melanoma Metastases Identifies Signatures Associated with Disease Progression and Therapeutic Resistance

(2020) Inna Smalley et al.   CLINICAL CANCER RESEARCH

Circulating epithelial tumor cell analysis in CSF in patients with leptomeningeal metastases

(2020) Mark T.J. van Bussel et al.   NEUROLOGY

Single-center phase I/Ib study of concurrent intrathecal (IT) and intravenous (IV) nivolumab (N) for metastatic melanoma (MM) patients (pts) with leptomeningeal disease (LMD).

(2020) Isabella Claudia Glitza et al.   JOURNAL OF CLINICAL ONCOLOGY

Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis

(2020) Priscilla K. Brastianos et al.   NATURE MEDICINE

Identification of Cerebrospinal Fluid MicroRNAs Associated With Leptomeningeal Metastasis From Lung Adenocarcinoma

(2020) Zhenyu Pan et al.   Frontiers in Oncology

A phase II, multicenter, two cohort study of 160 mg osimertinib in EGFR T790M-positive non-small-cell lung cancer patients with brain metastases or leptomeningeal disease who progressed on prior EGFR TKI therapy

(2020) S. Park et al.   ANNALS OF ONCOLOGY

Intrathecal administration of anti-HER2 treatment for the treatment of meningeal carcinomatosis in breast cancer: A metanalysis with meta-regression

(2020) Flora Zagouri et al.   CANCER TREATMENT REVIEWS

A Phase 2 Study of Abemaciclib in Patients with Brain Metastases Secondary to Hormone Receptor Positive Breast Cancer

(2020) Sara M Tolaney et al.   CLINICAL CANCER RESEARCH

Cerebrospinal fluid circulating tumor cells as a quantifiable measurement of leptomeningeal metastases in patients with HER2 positive cancer

(2020) Rachna Malani et al.   JOURNAL OF NEURO-ONCOLOGY

Clinical Trial of Proton Craniospinal Irradiation for Leptomeningeal Metastases

(2020) T Jonathan Yang et al.   NEURO-ONCOLOGY

Erlotinib for Non‐Small Cell Lung Cancer with Leptomeningeal Metastases: A Phase II Study ( LOGIK1101 )

(2020) Kaname Nosaki et al.   ONCOLOGIST

Whole brain radiotherapy (WBRT) for leptomeningeal metastasis from NSCLC in the era of targeted therapy: a retrospective study

(2020) Junjie Zhen et al.   Radiation Oncology

CSF cell-free DNA EGFR testing using DdPCR holds promise over conventional modalities for diagnosing leptomeningeal involvement in patients with non-small cell lung cancer

(2020) Moushumi Suryavanshi et al.   LUNG CANCER

Intra‐CSF topotecan in treatment of breast cancer patients with leptomeningeal metastases

(2020) Kurt A. Jaeckle et al.   Cancer Medicine

Prognostic validation and clinical implications of the EANO ESMO classification of leptomeningeal metastasis from solid tumors

(2020) Emilie Le Rhun et al.   NEURO-ONCOLOGY

Association of Neurosurgical Resection With Development of Pachymeningeal Seeding in Patients With Brain Metastases

(2019) Daniel N. Cagney et al.   JAMA Oncology

The RANO Leptomeningeal Metastasis Group proposal to assess response to treatment: lack of feasibility and clinical utility and a revised proposal

(2019) Emilie Le Rhun et al.   NEURO-ONCOLOGY

A Multi-Institutional Analysis of Presentation and Outcomes for Leptomeningeal Disease Recurrence After Surgical Resection and Radiosurgery for Brain Metastases

(2019) Roshan S Prabhu et al.   NEURO-ONCOLOGY

Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications

(2019) Adrienne Boire et al.   NEURO-ONCOLOGY

Phase II study of systemic high dose methotrexate and intrathecal liposomal cytarabine for treatment of leptomeningeal carcinomatosis from breast cancer

(2019) Maciej M. Mrugala et al.   Clinical Breast Cancer

Phase II study of irinotecan and temozolomide in breast cancer patients with progressing central nervous system disease

(2019) Michelle E. Melisko et al.   BREAST CANCER RESEARCH AND TREATMENT

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

The anatomy and immunology of vasculature in the central nervous system

(2019) Panagiotis Mastorakos et al.   Science Immunology

Predictors of Leptomeningeal Disease Following Hypofractionated Stereotactic Radiotherapy for Intact and Resected Brain Metastases

(2019) Timothy K Nguyen et al.   NEURO-ONCOLOGY

A Pilot Phase 1 Study of Intrathecal Pemetrexed for Refractory Leptomeningeal Metastases From Non-small-cell Lung Cancer

(2019) Zhenyu Pan et al.   Frontiers in Oncology

Nodular Leptomeningeal Disease – A Distinct Pattern of Recurrence After Post-Resection Stereotactic Radiosurgery for Brain Metastases: A Multi-Institutional Study of Inter-Observer Reliability

(2019) Brandon E. Turner et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Intrathecal liposomal cytarabine plus systemic therapy versus systemic chemotherapy alone for newly diagnosed leptomeningeal metastasis from breast cancer

(2019) Emilie Le Rhun et al.   NEURO-ONCOLOGY

Osimertinib in Patients With Epidermal Growth Factor Receptor Mutation–Positive Non–Small-Cell Lung Cancer and Leptomeningeal Metastases: The BLOOM Study

(2019) James C.H. Yang et al.   JOURNAL OF CLINICAL ONCOLOGY

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS

(2018) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Intrathecal trastuzumab in the management of HER2+ breast leptomeningeal disease: a single institution experience

(2018) Nicholas B. Figura et al.   BREAST CANCER RESEARCH AND TREATMENT

Leptomeningeal Metastases

(2018) Jerome J. Graber et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Phase I feasibility study for intrathecal administration of trastuzumab in patients with HER2 positive breast carcinomatous meningitis

(2018) Claire Bonneau et al.   EUROPEAN JOURNAL OF CANCER

Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+T cell trafficking

(2018) David Taggart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukaemia hijacks a neural mechanism to invade the central nervous system

(2018) Hisayuki Yao et al.   NATURE

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Efficacy of Osimertinib in EGFR-Mutated Non-Small Cell Lung Cancer with Leptomeningeal Metastases Pretreated with EGFR-Tyrosine Kinase Inhibitors

(2018) Karima Saboundji et al.   Targeted Oncology

Unique genomic profiles obtained from cerebrospinal fluid cell-free DNA of non-small cell lung cancer patients with leptomeningeal metastases

(2018) Shenpeng Ying et al.   CANCER BIOLOGY & THERAPY

Circumventricular Organs and Parasite Neurotropism: Neglected Gates to the Brain?

(2018) Marina Bentivoglio et al.   Frontiers in Immunology

EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid

(2017) Mark T. J. van Bussel et al.   JOURNAL OF NEURO-ONCOLOGY

METCopy Number Gain Is Associated with Gefitinib Resistance in Leptomeningeal Carcinomatosis ofEGFR-mutant Lung Cancer

(2017) Shigeki Nanjo et al.   MOLECULAR CANCER THERAPEUTICS

Cerebrospinal fluid circulating tumor cells: a novel tool to diagnose leptomeningeal metastases from epithelial tumors

(2017) Xuling Lin et al.   NEURO-ONCOLOGY

Leptomeningeal disease: current diagnostic and therapeutic strategies

(2017) Gautam Nayar et al.   Oncotarget

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma

(2016) M. H. Geukes Foppen et al.   ANNALS OF ONCOLOGY

FDA Approval: Alectinib for the Treatment of Metastatic, ALK-Positive Non-Small Cell Lung Cancer Following Crizotinib

(2016) E. Larkins et al.   CLINICAL CANCER RESEARCH

The Choroid Plexus in Healthy and Diseased Brain

(2016) Charanjit Kaur et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Leptomeningeal metastases: a RANO proposal for response criteria

(2016) Marc Chamberlain et al.   NEURO-ONCOLOGY

FDA Approval: Ceritinib for the Treatment of Metastatic Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer

(2015) S. Khozin et al.   CLINICAL CANCER RESEARCH

A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Non–Small-Cell Lung Cancer Patients with Leptomeningeal Carcinomatosis

(2015) Bin-Chi Liao et al.   Journal of Thoracic Oncology

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells

(2015) Shigeki Nanjo et al.   Oncotarget

Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels

(2015) Qingtang Lin et al.   NEOPLASIA

Leptomeningeal disease and breast cancer: the importance of tumor subtype

(2014) Sausan Abouharb et al.   BREAST CANCER RESEARCH AND TREATMENT

COX-2 Drives Metastatic Breast Cells from Brain Lesions into the Cerebrospinal Fluid and Systemic Circulation

(2014) J. E. Allen et al.   CANCER RESEARCH

Leptomeningeal metastasis: a Response Assessment in Neuro-Oncology critical review of endpoints and response criteria of published randomized clinical trials

(2014) M. Chamberlain et al.   NEURO-ONCOLOGY

A retrospective case series of 103 consecutive patients with leptomeningeal metastasis and breast cancer

(2013) E. Le Rhun et al.   JOURNAL OF NEURO-ONCOLOGY

Analysis of Treatment Outcomes of Intraventricular Chemotherapy in 105 Patients for Leptomeningeal Carcinomatosis from Non–Small-Cell Lung Cancer

(2013) Ho-Shin Gwak et al.   Journal of Thoracic Oncology

Leptomeningeal Carcinomatosis in Non–Small-Cell Lung Cancer Patients: Impact on Survival and Correlated Prognostic Factors

(2013) Su Jin Lee et al.   Journal of Thoracic Oncology

The Central Nervous System as a Sanctuary Site in ALK-Positive Non–Small-Cell Lung Cancer

(2013) Justin F. Gainor et al.   Journal of Thoracic Oncology

Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival

(2013) Anna Niwińska et al.   MEDICAL ONCOLOGY

Detection and quantification of CSF malignant cells by the CellSearch® technology in patients with melanoma leptomeningeal metastasis

(2013) Emilie Le Rhun et al.   MEDICAL ONCOLOGY

Risk for leptomeningeal seeding after resection for brain metastases: implication of tumor location with mode of resection

(2012) Jun Hyong Ahn et al.   JOURNAL OF NEUROSURGERY

Central Nervous System Metastases in Patients with HER2-Positive Metastatic Breast Cancer: Incidence, Treatment, and Survival in Patients from registHER

(2011) A. M. Brufsky et al.   CLINICAL CANCER RESEARCH

Meningeal carcinomatosis in breast cancer: prognostic factors and outcome

(2011) Carla Rameri Alexandre Silva de Azevedo et al.   JOURNAL OF NEURO-ONCOLOGY

Leptomeningeal Metastasis from Non-small Cell Lung Cancer: Survival and the Impact of Whole Brain Radiotherapy

(2011) Patrick G. Morris et al.   Journal of Thoracic Oncology

Leptomeningeal metastases in the MRI era

(2010) J. L. Clarke et al.   NEUROLOGY

Brain metastases admissions in Sweden between 1987 and 2006

(2009) K E Smedby et al.   BRITISH JOURNAL OF CANCER

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

COMPARATIVE RISK OF LEPTOMENINGEAL DISSEMINATION OF CANCER AFTER SURGERY OR STEREOTACTIC RADIOSURGERY FOR A SINGLE SUPRATENTORIAL SOLID TUMOR METASTASIS

(2009) Dima Suki et al.   NEUROSURGERY

Prognostic factors and clinical outcomes in patients with leptomeningeal metastasis from solid tumors

(2008) Fusako Waki et al.   JOURNAL OF NEURO-ONCOLOGY

A multicenter phase II trial of intrathecal topotecan in patients with meningeal malignancies

(2008) Morris D. Groves et al.   NEURO-ONCOLOGY

Prognostic factors and outcomes in patients with leptomeningeal melanomatosis

(2008) Laura Harstad et al.   NEURO-ONCOLOGY