Article
Oncology
Wenjin Yu, Yangyang Liu, Yunsong Zhao, Haofan Huang, Jiahao Liu, Xiaofeng Yao, Jingwen Li, Zhen Xie, Luyue Jiang, Heping Wu, Xinhao Cao, Jiaming Zhou, Yuting Guo, Gaoyang Li, Matthew Xinhu Ren, Yi Quan, Tingmin Mu, Guillermo Ayuso Izquierdo, Guoxun Zhang, Runze Zhao, Di Zhao, Jiangyun Yan, Haijun Zhang, Junchao Lv, Qian Yao, Yan Duan, Huimin Zhou, Tingting Liu, Ying He, Ting Bian, Wen Dai, Jiahui Huai, Xiyuan Wang, Qian He, Yi Gao, Wei Ren, Gang Niu, Gang Zhao
Summary: This study establishes a deep learning model to classify cancer cells in cerebrospinal fluid (CSF) for the diagnosis of leptomeningeal metastasis (LM). The model achieves high accuracy and effectively facilitates the screening of cancer cells. Additionally, a computer-aided diagnosis software is developed to generate cytology diagnosis reports rapidly, saving significant working time. The application of deep learning and CAD software shows promise in expediting LM diagnosis and improving prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Neurosciences
Shengnan Wang, Wenzhuo Yang, Mingqin Zhu, Xiaochuang Wang, Lin Pan, Tao Jin, Youqi Chen, Jianxin Xi, Laiyu Yang, Run Cui
Summary: This case describes a patient with symptoms of acute lower extremity weakness, dysuria, and high intracranial pressure. Enhanced MRI showed extensive enhancement of the leptomeningeal and spinal meninges. Initially diagnosed as miliary TB with associated tuberculous meningitis, further inspection revealed malignant cells in the cerebrospinal fluid. PET/CT confirmed the diagnosis of leptomeningeal metastasis. Overall, early diagnosis and active treatment are important for improving survival rate.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Ferdinand Otto, Christine Harrer, Georg Pilz, Peter Wipfler, Andrea Harrer
Summary: Cerebrospinal fluid (CSF) has seen a resurgence in diagnostics and research, but advancements in CSF cell analysis have been limited. While CSF cell count and cytology have been central in diagnosing CNS diseases, the lack of incorporation of modern immune phenotyping technologies has left valuable information unexplored. This gap is particularly concerning given the important role of CSF cells in CNS immune defense and autoimmune processes, as well as the diagnostic challenges posed by overlapping infectious and immune-mediated CNS diseases.
Article
Oncology
Ning Li, Zhimin Bian, Minghua Cong, Yutao Liu
Summary: This study confirms that patients with EGFR-mutated NSCLC who are diagnosed with leptomeningeal metastasis have better clinical outcomes with osimertinib therapy. The study also reveals that disease control of leptomeningeal metastasis is the most effective strategy for prolonging overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agronomy
Vijayakumari Narukulla, Yogesh Lahane, Krutika Fiske, Shashi Pandey, Vasileios Ziogas
Summary: In this study, stable tetraploids were developed in citrus rootstock cultivars including Rough lemon, Rangpur lime, and Alemow through in vitro colchicine treatments. The treatment with 0.1% colchicine for 24 hours resulted in the highest tetraploid induction percentage (18.3%) in all the rootstock cultivars.
Article
Veterinary Sciences
Valentina Lorenzo, Joao Ribeiro, Marco Bernardini, Juan J. Minguez, Meritxell Moral, Carlos Blanco, Tina Loncarica, Araceli Gamito, Marti Pumarola
Summary: This multicentric retrospective study describes the clinical and MRI features and pathological studies of spinal lymphoma in 27 cats. The study found that spinal lymphoma typically presents as an ill-defined epidural focal lesion on MRI, with compression of the spinal cord. The lesions are often localized in the lumbar vertebral segment and have certain MRI characteristics and histopathological features. Abdominal pain and neck pain are the most common neurological symptoms of spinal lymphoma, and MRI can assist in the diagnosis of spinal lymphoma.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Clinical Neurology
Chien-Chin Chen, Pei-Chun Chiang, Tsung-Hsien Chen
Summary: The COVID-19 outbreak has raised concerns about its potential involvement in the central nervous system and various neurological complications. However, there is a lack of clear guidelines on the sampling, processing, and risk assessment of neurological specimens in the context of the pandemic.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Yujun Bai, Qingxi Yu, Ning Liu, Jingwen Liu, Di Wang, Xiaoli Liu, Shuanghu Yuan
Summary: Leptomeningeal metastasis (LM) is rare in non-small cell lung cancer patients and current diagnostic methods have limitations. Recent studies have found that circulating tumor DNA (ctDNA) in cerebrospinal fluid can potentially serve as an early diagnostic biomarker for LM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Hematology
Nadine Martins Castanheira, Anna K. Spanhofer, Sebastian Wiener, Stefanie Bobe, Hermann Schillers
Summary: The study revealed that cancer cells hijack platelets by phagocytosis and recycling of platelet membrane proteins, aiding in cancer cell survival and metastasis. The process of platelet uptake can be tracked, with positive platelet uptake observed in tested cancer cells but not in non-cancerous cells.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Clinical Neurology
Raban Arved Heller, Julian Seelig, Helena Lucia Crowell, Maximilian Pilz, Patrick Haubruck, Qian Sun, Lutz Schomburg, Volker Daniel, Arash Moghaddam, Bahram Biglari
Summary: This study aimed to evaluate the correlation between remission after traumatic spinal cord injury and the dynamics of monocyte subsets, lymphocytes' responsive potential, cytokine expression, patterns of trace element concentration, and clinical covariates. Clinical research findings suggest that early dynamics in monocyte subsets can predict recovery from traumatic spinal cord injury.
Article
Medical Laboratory Technology
Kazuya Takahashi, Kentaro Kurashina, Shin Saito, Rihito Kanamaru, Hideyuki Ohzawa, Hironori Yamaguchi, Hideyo Miyato, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Summary: The study showed that the detection of tumor cells in ascites or peritoneal lavages using flow cytometry is correlated with the progression of peritoneal metastases. Tumor-leukocyte ratio (TLR) is associated with peritoneal cancer index scores and the ratios of different cell types.
CYTOMETRY PART B-CLINICAL CYTOMETRY
(2021)
Article
Oncology
Margaux Wooster, Julia E. McGuinness, Kathleen M. Fenn, Veena M. Singh, Lauren E. Franks, Shing Lee, David Cieremans, Andrew B. Lassman, Dawn L. Hershman, Katherine D. Crew, Melissa K. Accordino, Meghna S. Trivedi, Fabio Iwamoto, Mary R. Welch, Aya Haggiagi, Robbie D. Schultz, Lan Huynh, Edgar Sales, Deanna Fisher, Julie Ann Mayer, Teri Kreisl, Kevin Kalinsky
Summary: This study evaluates a novel assay called CNSide, which shows 100% sensitivity for detecting leptomeningeal metastasis (LM) in metastatic breast cancer patients, overcoming the limitations of low sensitivity in cerebrospinal fluid cytopathology. CNSide also has the capacity to assess receptor expression and identify mutations. It may serve as a viable platform for LM detection and a potential diagnostic tool.
CLINICAL BREAST CANCER
(2022)
Article
Immunology
A. Elisabeth Gressler, Sabrina Luebke, Bettina Wagner, Corinna Arnold, Katharina L. Lohmann, Christiane L. Schnabel
Summary: Equine asthma, a common disease affecting approximately 20% of horses, shows similarities to human asthma and is believed to be immune-mediated. By analyzing the cell populations in the lower airways of horses with different severities of equine asthma, researchers identified characteristic changes in the cell compositions, highlighting potential differences between severe cases and mild to moderate cases as well as healthy horses. These findings contribute to a better understanding of the pathogenesis of equine asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Parikshaa Gupta, Nalini Gupta, Amanjit Bal, Pulkit Rastogi, Gaurav Prakash, Pankaj Malhotra, Pranab Dey, Radhika Srinivasan, Ashim Das
Summary: This study aimed to identify the distinctive cytomorphological features of angioimmunoblastic T cell lymphoma (AITL) in lymph node fine-needle aspirates (LN-FNA) through a retrospective case-control study. The results showed that the absence of tingible body macrophages, presence of atypical lymphoid cells, and singly scattered epithelioid cells in polymorphic LN-FNAs were significant cytomorphological predictors of AITL in comparison with reactive lymphoid hyperplasia (RLH).
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Lindsay Angus, Teoman Deger, Agnes Jager, John W. M. Martens, Vanja de Weerd, Irene van Heuvel, Martin J. van den Bent, Peter A. E. Sillevis Smitt, Johan M. Kros, Eric M. J. Bindels, Ellen Heitzer, Stefan Sleijfer, Joost L. M. Jongen, Saskia M. Wilting
Summary: Detection of aneuploidy in cell-free DNA from cerebrospinal fluid may serve as a promising biomarker for timely detection of leptomeningeal metastasis in breast cancer patients. A high success rate of the mFAST-SeqS method in detecting genome-wide aneuploidy suggests its potential usefulness in improving overall survival outcomes.
CLINICAL CANCER RESEARCH
(2021)
Letter
Oncology
Mei-Yin C. Polley, Thierry Gorlia, Andy B. Lassman, Martin J. van den Bent
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Julie J. Miller, L. Nicolas Gonzalez Castro, Samuel McBrayer, Michael Weller, Timothy Cloughesy, Jana Portnow, Ovidiu Andronesi, Jill S. Barnholtz-Sloan, Brigitta G. Baumert, Mitchell S. Berger, Wenya Linda Bi, Ranjit Bindra, Daniel P. Cahill, Susan M. Chang, Joseph F. Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. Mellinghoff, L. Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Hai Yan, Andreas von Deimling, Martin van den Bent, William G. Kaelin, Patrick Y. Wen
Summary: This article discusses the diagnosis and management of IDH-mutant gliomas, as well as new treatment methods and future research directions.
Article
Oncology
Youri Hoogstrate, Kaspar Draaisma, Santoesha A. Ghisai, Levi van Hijfte, Nastaran Barin, Iris de Heer, Wouter Coppieters, Thierry P. P. van den Bosch, Anne Bolleboom, Zhenyu Gao, Arnaud J. P. E. Vincent, Latifa Karim, Manon Deckers, Martin J. B. Taphoorn, Melissa Kerkhof, Astrid Weyerbrock, Marc Sanson, Ann Hoeben, Slavka Lukacova, Giuseppe Lombardi, Sieger Leenstra, Monique Hanse, Ruth E. M. Fleischeuer, Colin Watts, Nicos Angelopoulos, Thierry Gorlia, Vassilis Golfinopoulos, Vincent Bours, Martin J. van den Bent, Pierre A. Robe, Pim J. French
Summary: A better understanding of the transcriptional evolution of IDH-wild-type glioblastoma is crucial for optimizing treatment. Through RNA sequencing, this study demonstrates that glioblastomas mainly evolve through microenvironmental reorganization rather than molecular evolution of tumor cells. The changes in tumor composition over time, including alterations in neuron and oligodendrocyte marker genes and an increase in tumor-associated macrophages, are confirmed by single-cell RNA-seq and immunohistochemistry.
Article
Oncology
Caroline Hertler, Joerg Felsberg, Dorothee Gramatzki, Emilie Le Rhun, Jennifer Clarke, Riccardo Soffietti, Wolfgang Wick, Olivier Chinot, Francois Ducray, Patrick Roth, Kerrie McDonald, Peter Hau, Andreas F. Hottinger, Jaap Reijneveld, Oliver Schnell, Christine Marosi, Michael Glantz, Amelie Darlix, Giuseppe Lombardi, Dietmar Krex, Martin Glas, David A. Reardon, Martin van den Bent, Florence Lefranc, Ulrich Herrlinger, Evangelia Razis, Antoine F. Carpentier, Samuel Phillips, Roberta Ruda, Antje Wick, Emeline Tabouret, David Meyronet, Claude-Alain Maurage, Elisabeth Rushing, Robert Rapkins, Elisabeth Bumes, Monika Hegi, Astrid Weyerbrock, Dawit Aregawi, Christian Gonzalez-Gomez, Alessia Pellerino, Martin Klein, Matthias Preusser, Martin Bendszus, Vassilis Golfinopoulos, Andreas von Deimling, Thierry Gorlia, Patrick Y. Wen, Guido Reifenberger, Michael Weller
Summary: This study analyzed patients with glioblastoma who survived at least 5 years and found that only a few patients can survive for longer periods. The characteristics and factors associated with long-term survival remain poorly defined.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Clinical Neurology
Pim B. van der Meer, Linda Dirven, Marta Fiocco, Maaike J. Vos, Mathilde C. M. Kouwenhoven, Martin J. van den Bent, Martin J. B. Taphoorn, Johan A. F. Koekkoek
Summary: This study aimed to evaluate the effectiveness of levetiracetam combined with valproic acid and clobazam compared with other triple therapy combinations in patients with glioma. The results showed that there were no significant differences in treatment failure rate, uncontrolled seizure rate, adverse effects rate, and recurrent seizure rate between levetiracetam combined with valproic acid and clobazam and other triple therapy combinations.
Article
Medicine, General & Internal
Ingo K. Mellinghoff, Martin J. van den Bent, Deborah T. Blumenthal, Mehdi Touat, Katherine B. Peters, Jennifer Clarke, Joe Mendez, Shlomit Yust-Katz, Liam Welsh, Warren P. Mason, Francois Ducray, Yoshie Umemura, Burt Nabors, Matthias Holdhoff, Andreas F. Hottinger, Yoshiki Arakawa, Juan M. Sepulveda, Wolfgang Wick, Riccardo Soffietti, James R. Perry, Pierre Giglio, Macarena de la Fuente, Elizabeth A. Maher, Steven Schoenfeld, Dan Zhao, Shuchi S. Pandya, Lori Steelman, Islam Hassan, Patrick Y. Wen, Timothy F. Cloughesy
Summary: In a phase 3 trial, vorasidenib showed significant improvement in progression-free survival and delay in the time to the next intervention for patients with grade 2 IDH-mutant glioma.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Clinical Neurology
M. J. van den Bent
Summary: This paper reviews the 30-year development of low-grade gliomas, including changes in diagnostics with the incorporation of 1p/19q and IDH mutations, improved surgical techniques, and improved delivery of radiotherapy and chemotherapy. Recently, the better understanding of altered cellular processes has led to the development of novel drugs that may completely alter the management of patients early in their disease.
REVUE NEUROLOGIQUE
(2023)
Article
Oncology
Ioannis Ntafoulis, Anne Kleijn, Jie Ju, Kevin Jimenez-Cowell, Federica Fabro, Michelle Klein, Romain Tching Chi Yen, Rutger K. Balvers, Yunlei Li, Andrew P. Stubbs, Trisha V. Kers, Johan M. Kros, Sean E. Lawler, Laurens V. Beerepoot, Andreas Kremer, Ahmed Idbaih, Maite Verreault, Annette T. Byrne, Alice C. O'Farrell, Kate Connor, Archita Biswas, Manuela Salvucci, Jochen H. M. Prehn, Diether Lambrechts, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Martin J. van den Bent, Clemens M. F. Dirven, Sieger Leenstra, Martine L. M. Lamfers
Summary: This study found that patient-derived glioma stem-like cells (GSCs) retain patient-unique gene expressions despite the loss of their natural environment. Drug screening using GSCs predicted patient response to temozolomide (TMZ) more specifically than the MGMT status alone. Transcriptome analysis identified potential biomarkers for TMZ sensitivity.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Tobias Kessler, Daniel Schrimpf, Laura Doerner, Ling Hai, Leon D. Kaulen, Jakob Ito, Martin van den Bent, Martin Taphoorn, Alba A. Brandes, Ahmed Idbaih, Julien Domont, Paul M. Clement, Mario Campone, Martin Bendszus, Andreas von Deimling, Felix Sahm, Michael Platten, Wolfgang Wick, Antje Wick
Summary: The EORTC-26101 study investigated the efficacy of combination therapy with bevacizumab and lomustine versus lomustine alone in progressive glioblastoma. Molecular data from DNA methylation arrays and panel sequencing were analyzed to assess prognostic biomarkers. The study found that MGMT promoter methylation and RTK1 classifier assignment were prognostic factors, while NF1 mutation may predict response to bevacizumab treatment.
CLINICAL CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Riccardo Soffietti, Alessia Pellerino, Francesco Bruno, Alessandro Mauro, Roberta Ruda
Summary: Research on brain damage mechanisms following radiation treatments for brain tumors has increased, providing insight into pathobiological mechanisms and suggesting new approaches to minimize damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Oncology
Patrick Y. Wen, Martin van den Bent, Michael A. Vogelbaum, Susan M. Chang
Article
Oncology
Philipp Karschnia, Jorg Dietrich, Francesco Bruno, Antonio Dono, Stephanie T. Juenger, Nico Teske, Jacob S. Young, Tommaso Sciortino, Levin Haeni, Martin van den Bent, Michael Weller, Michael A. Vogelbaum, Ramin A. Morshed, Alexander F. Haddad, Annette M. Molinaro, Nitin Tandon, Juergen Beck, Oliver Schnell, Lorenzo Bello, Shawn Hervey-Jumper, Niklas Thon, Stefan J. Grau, Yoshua Esquenazi, Roberta Ruda, Susan M. Chang, Mitchel S. Berger, Daniel P. Cahill, Joerg-Christian Tonn
Summary: The absence of contrast enhancement in glioblastomas characterizes a less aggressive clinical phenotype, with smaller postoperative tumor volumes associated with more favorable outcomes. Maximal resection of non-CE tumors has prognostic implications and leads to a better outcome compared to lesion biopsy. Patients with non-CE glioblastoma have a more favorable clinical profile and superior outcome when compared to those with CE glioblastoma.
Article
Oncology
Karin A. van Garderen, Wies R. Vallentgoed, Anna Lavrova, Johanna M. Niers, Wendy W. J. de Leng, Youri Hoogstrate, Iris de Heer, Bauke Ylstra, Erik van Dijk, Stefan Klein, Kaspar Draaisma, Pierre A. J. T. Robe, Roel G. W. Verhaak, Bart A. Westerman, Pim J. French, Martin J. van den Bent, Mathilde C. M. Kouwenhoven, Johan M. Kros, Pieter Wesseling, Marion Smits
Summary: The T2-FLAIR mismatch sign is correlated with microcystic change in IDH-mutant astrocytomas, favorable prognosis, and Grade 2 tumors.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wouter H. T. Teunissen, Anna Lavrova, Martin van den Bent, Anouk van der Hoorn, Esther A. H. Warnert, Marion Smits
Summary: This study investigates the correlation and diagnostic accuracy of quantitative cerebral blood flow and non-quantitative perfusion weighted imaging measurements in brain tumour surveillance using arterial spin labelling MRI. The results show that there is a high correlation between ASL-PWI ratios and ASL-CBF ratios and their diagnostic accuracy is comparable. Therefore, quantification of ASL-CBF can be omitted in these patients and visual assessment provides the same diagnostic accuracy as quantitative measurements.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wouter H. T. Teunissen, Anna Lavrova, Martin van den Bent, Anouk van der Hoorn, Esther A. H. Warnert, Marion Smits
Summary: ASL-PWI has higher diagnostic accuracy than ASL-CBF, indicating that quantification of ASL-CBF can be omitted for brain tumour surveillance.
EUROPEAN RADIOLOGY
(2023)