Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications

Unique genetic profiles from cerebrospinal fluid cell-free DNA in leptomeningeal metastases of EGFR-mutant non-small-cell lung cancer: a new medium of liquid biopsy

(2018) Y S Li et al.   ANNALS OF ONCOLOGY

Molecular Profiling of Liquid Biopsy Samples for Precision Medicine

(2018) Camila D.M. Campos et al.   CANCER JOURNAL

Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer

(2018) Daniel G. Stover et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical trial design for local therapies for brain metastases: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group

(2018) Brian M Alexander et al.   LANCET ONCOLOGY

Clinical trial design for systemic agents in patients with brain metastases from solid tumours: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group

(2018) D Ross Camidge et al.   LANCET ONCOLOGY

Liquid biopsy for brain tumors

(2017) Ganesh M. Shankar et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Applications of DNA-Based Liquid Biopsy for Central Nervous System Neoplasms

(2017) Joanna Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid

(2017) Mark T. J. van Bussel et al.   JOURNAL OF NEURO-ONCOLOGY

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Cerebrospinal fluid circulating tumor cells: a novel tool to diagnose leptomeningeal metastases from epithelial tumors

(2017) Xuling Lin et al.   NEURO-ONCOLOGY

Clinical significance of detecting CSF-derived tumor cells in breast cancer patients with leptomeningeal metastasis

(2017) Xuelu Li et al.   Oncotarget

Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer

(2016) W. J. Janni et al.   CLINICAL CANCER RESEARCH

The “Liquid Biopsy”: the Role of Circulating DNA and RNA in Central Nervous System Tumors

(2016) Ian D. Connolly et al.   Current Neurology and Neuroscience Reports

Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid

(2016) Elena I. Pentsova et al.   JOURNAL OF CLINICAL ONCOLOGY

SHP-1 promoter 2 methylation in cerebrospinal fluid for diagnosis of leptomeningeal epithelial-derived malignancy (carcinomatous meningitis)

(2016) Chanida Vinayanuwattikun et al.   JOURNAL OF NEURO-ONCOLOGY

Tumor DNA in cerebral spinal fluid reflects clinical course in a patient with melanoma leptomeningeal brain metastases

(2016) Yingmei Li et al.   JOURNAL OF NEURO-ONCOLOGY

Quantification of tumor-derived cell free DNA(cfDNA) by digital PCR (DigPCR) in cerebrospinal fluid of patients with BRAFV600 mutated malignancies

(2016) Parisa Momtaz et al.   Oncotarget

Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer

(2016) Kyung-A Hyun et al.   Oncotarget

Digital PCR quantification ofMGMTmethylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer

(2015) L. Barault et al.   ANNALS OF ONCOLOGY

Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer

(2015) J. Tie et al.   ANNALS OF ONCOLOGY

Detection of cerebrospinal fluid tumor cells and its clinical relevance in leptomeningeal metastasis of breast cancer

(2015) Jin Sun Lee et al.   BREAST CANCER RESEARCH AND TREATMENT

Diagnostic and prognostic significance of flow cytometry immunophenotyping in patients with leptomeningeal carcinomatosis

(2015) D. Subirá et al.   CLINICAL & EXPERIMENTAL METASTASIS

Detection and Dynamic Changes of EGFR Mutations from Circulating Tumor DNA as a Predictor of Survival Outcomes in NSCLC Patients Treated with First-line Intercalated Erlotinib and Chemotherapy

(2015) T. Mok et al.   CLINICAL CANCER RESEARCH

Brain Tumor Mutations Detected in Cerebral Spinal Fluid

(2015) W. Pan et al.   CLINICAL CHEMISTRY

Screening of carcinoma metastasis by flow cytometry: A study of 238 cases

(2015) Maria Acosta et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

CellSearch® technology applied to the detection and quantification of tumor cells in CSF of patients with lung cancer leptomeningeal metastasis

(2015) Qian Tu et al.   LUNG CANCER

EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291

(2015) Kenneth S. Thress et al.   LUNG CANCER

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors

(2015) Bojana Milojkovic Kerklaan et al.   NEURO-ONCOLOGY

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

(2015) Isaac Garcia-Murillas et al.   Science Translational Medicine

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

(2015) Leticia De Mattos-Arruda et al.   Nature Communications

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

(2015) P. K. Brastianos et al.   Cancer Discovery

Association ofEGFRL858R Mutation in Circulating Free DNA With Survival in the EURTAC Trial

(2015) Niki Karachaliou et al.   JAMA Oncology

Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases

(2015) Akshal S. Patel et al.   Oncotarget

Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer

(2014) J. A. Beaver et al.   CLINICAL CANCER RESEARCH

MGMT promoter methylation in plasma of glioma patients receiving temozolomide

(2014) Valentina Fiano et al.   JOURNAL OF NEURO-ONCOLOGY

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

(2014) François-Clément Bidard et al.   LANCET ONCOLOGY

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

(2014) Aaron M Newman et al.   NATURE MEDICINE

Acquired resistance to TKIs in solid tumours: learning from lung cancer

(2014) D. Ross Camidge et al.   Nature Reviews Clinical Oncology

Leptomeningeal metastasis: a Response Assessment in Neuro-Oncology critical review of endpoints and response criteria of published randomized clinical trials

(2014) M. Chamberlain et al.   NEURO-ONCOLOGY

Blockade of EGFR and MEK Intercepts Heterogeneous Mechanisms of Acquired Resistance to Anti-EGFR Therapies in Colorectal Cancer

(2014) S. Misale et al.   Science Translational Medicine

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Molecular Profiling of Tumor Cells in Cerebrospinal Fluid and Matched Primary Tumors from Metastatic Breast Cancer Patients with Leptomeningeal Carcinomatosis

(2013) M. J. M. Magbanua et al.   CANCER RESEARCH

Detection and quantification of CSF malignant cells by the CellSearch® technology in patients with melanoma leptomeningeal metastasis

(2013) Emilie Le Rhun et al.   MEDICAL ONCOLOGY

Rare cell capture technology for the diagnosis of leptomeningeal metastasis in solid tumors

(2013) L. Nayak et al.   NEUROLOGY

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epithelial Cell Adhesion Molecule-positive Circulating Tumor Cells as Predictive Biomarker in Patients With Prostate Cancer

(2013) Robert J. Amato et al.   UROLOGY

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer

(2013) Alberto Bardelli et al.   Cancer Discovery

Relationship among circulating tumor cells, CEA and overall survival in patients with metastatic colorectal cancer

(2012) C. Aggarwal et al.   ANNALS OF ONCOLOGY

Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer

(2012) Yosuke Togashi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Meta-Analysis of the Prognostic Value of Circulating Tumor Cells in Breast Cancer

(2012) L. Zhang et al.   CLINICAL CANCER RESEARCH

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Role of flow cytometry immunophenotyping in the diagnosis of leptomeningeal carcinomatosis

(2011) Dolores Subirá et al.   NEURO-ONCOLOGY

Circulating Tumor Cells in the Management of Breast Cancer

(2010) Govardhanan Nagaiah et al.   Clinical Breast Cancer

External quality assurance of circulating tumor cell enumeration using the CellSearch® system: A feasibility study

(2010) Jaco Kraan et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE