The Role of Hypoxia in Glioblastoma Radiotherapy Resistance

Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy

(2020) Jac A. Nickoloff et al.   Genes

O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy

(2020) Wei Yu et al.   Frontiers in Oncology

Glioblastoma: Pathogenesis and Current Status of Chemotherapy and Other Novel Treatments

(2020) Vilashini Rajaratnam et al.   Cancers

Investigating Glioblastoma Response to Hypoxia

(2020) Agathe L. Chédeville et al.   Biomedicines

Recurrent Glioblastoma: From Molecular Landscape to New Treatment Perspectives

(2020) Cristina Birzu et al.   Cancers

The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma

(2019) Martha Foltyn et al.   BRITISH JOURNAL OF CANCER

Annexin A2 Regulates AKT Upon H2O2-Dependent Signaling Activation in Cancer Cells

(2019) Stéphanie Castaldo et al.   Cancers

Hypoxic glioma cells-secreted exosomal miR-301a activates the Wnt/β-catenin signaling and promotes radiation resistance by targeting TCEAL7

(2019) Xiao Yue et al.   MOLECULAR THERAPY

Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression

(2019) Saxena et al.   Biomolecules

The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding

(2019) Marta Helena Kubala et al.   CANCER AND METASTASIS REVIEWS

ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade

(2019) Yu-Ting Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia

(2018) Julian Hlouschek et al.   Frontiers in Oncology

Mechanisms of DNA damage, repair, and mutagenesis

(2017) Nimrat Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

GBM radiosensitizers: dead in the water…or just the beginning?

(2017) Ranjit S. Bindra et al.   JOURNAL OF NEURO-ONCOLOGY

Time- and oxygen-dependent expression and regulation of NDRG1 in human brain cancer cells

(2017) Harun Muayad Said et al.   ONCOLOGY REPORTS

The Role of Hypoxia in Glioblastoma Invasion

(2017) Ana Monteiro et al.   Cells

In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies

(2017) Joseph A. Pinto et al.   Scientific Reports

Hypoxia-inducible factor 3 biology: complexities and emerging themes

(2016) Cunming Duan   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia

(2016) Johann Matschke et al.   ANTIOXIDANTS & REDOX SIGNALING

FGFR1 Induces Glioblastoma Radioresistance through the PLC /Hif1  Pathway

(2016) V. Gouaze-Andersson et al.   CANCER RESEARCH

The Tumorigenic Roles of the Cellular REDOX Regulatory Systems

(2016) Stéphanie Anaís Castaldo et al.   Oxidative Medicine and Cellular Longevity

c-MYC inhibition impairs hypoxia response in glioblastoma multiforme

(2016) Maria Patrizia Mongiardi et al.   Oncotarget

Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance

(2016) Alessia Fidoamore et al.   Stem Cells International

Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism

(2015) H. Shen et al.   MOLECULAR CANCER THERAPEUTICS

Variation over time and interdependence between disease progression and death among patients with glioblastoma on RTOG 0525

(2015) Meihua Wang et al.   NEURO-ONCOLOGY

Comprehensive Analysis of Glycolytic Enzymes as Therapeutic Targets in the Treatment of Glioblastoma

(2015) Morgane Sanzey et al.   PLoS One

The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.

(2015) Olga Catalina-Rodriguez et al.   Oncotarget

Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay

(2014) FRANCESCO MARAMPON et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cancer stem cells and radioresistance

(2014) Kiera Rycaj et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Angiogenesis and expression of PDGF-C, VEGF, CD105 and HIF-1α in human glioblastoma

(2014) Carlos Afonso Clara et al.   NEUROPATHOLOGY

Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance

(2014) P Dahan et al.   Cell Death & Disease

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

Ionizing Radiation-Induced DNA Damage, Response, and Repair

(2013) Wil L. Santivasi et al.   ANTIOXIDANTS & REDOX SIGNALING

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

(2013) Mark R. Gilbert et al.   JOURNAL OF CLINICAL ONCOLOGY

Preoperative dynamic contrast-enhanced MRI correlates with molecular markers of hypoxia and vascularity in specific areas of intratumoral microenvironment and is predictive of patient outcome

(2013) Randy L. Jensen et al.   NEURO-ONCOLOGY

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

(2013) M. Weiler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

(2012) Y.-L. Hu et al.   CANCER RESEARCH

Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications

(2012) Liuqi Yang et al.   EXPERIMENTAL CELL RESEARCH

NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme

(2012) Chia-Hung Hsieh et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Biochemistry and Regulation of S100A10: A Multifunctional Plasminogen Receptor Involved in Oncogenesis

(2012) Patricia A. Madureira et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Targeting Tumor Perfusion and Oxygenation to Improve the Outcome of Anticancer Therapy1

(2012) Bénédicte F. Jordan et al.   Frontiers in Pharmacology

The role of the annexin A2 heterotetramer in vascular fibrinolysis

(2011) P. A. Madureira et al.   BLOOD

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential

(2011) J M Heddleston et al.   CELL DEATH AND DIFFERENTIATION

Water Radiolysis: Influence of Oxide Surfaces on H2 Production under Ionizing Radiation

(2011) Sophie Le Caër   Water

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Effects of hypoxia on expression of a panel of stem cell and chemoresistance markers in glioblastoma-derived spheroids

(2010) Jesper Kolenda et al.   JOURNAL OF NEURO-ONCOLOGY

Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres

(2010) Olga Méndez et al.   Molecular Cancer

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity

(2010) Hsieh   ONCOLOGY REPORTS

Inhibition of 4E-BP1 Sensitizes U87 Glioblastoma Xenograft Tumors to Irradiation by Decreasing Hypoxia Tolerance

(2009) Ludwig Dubois et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Chromium-mediated apoptosis: Involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes

(2008) Richard Hill et al.   DNA REPAIR

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE