Autologous Regulatory T Cells for the Treatment of Type 1 Diabetes

CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity

(2014) E. M. Schmidt et al.   JOURNAL OF IMMUNOLOGY

IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development

(2014) K. B. Vang et al.   JOURNAL OF IMMUNOLOGY

TCR affinity and specificity requirements for human regulatory T-cell function

(2012) G. Plesa et al.   BLOOD

Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice

(2012) Shounan Yi et al.   DIABETES

Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase

(2012) C. C. Patterson et al.   DIABETOLOGIA

Comparative study of regulatory T cells expanded ex vivo from cord blood and adult peripheral blood

(2012) Huahua Fan et al.   IMMUNOLOGY

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PTPN22 Alters the Development of Regulatory T Cells in the Thymus

(2012) C. J. Maine et al.   JOURNAL OF IMMUNOLOGY

Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function

(2012) G. Garg et al.   JOURNAL OF IMMUNOLOGY

Cord Blood Derived CD4+CD25high T Cells Become Functional Regulatory T Cells upon Antigen Encounter

(2012) Elisabeth Mayer et al.   PLoS One

A Simple and Effective Method to Generate Lentiviral Vectors for Ex Vivo Gene Delivery to Mature Human Peripheral Blood Lymphocytes

(2012) Shicheng Yang et al.   Human Gene Therapy Methods

Advances in Imaging Gene-Directed Enzyme Prodrug Therapy

(2011) Srabani Bhaumik   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function

(2011) K. D. Gerold et al.   DIABETES

Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes

(2011) Alessandra Ferraro et al.   DIABETES

Polyclonal Treg cells modulate T effector cell trafficking

(2011) Todd S. Davidson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

(2011) Garth L. Burn et al.   FEBS LETTERS

Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells

(2011) David M. Barrett et al.   HUMAN GENE THERAPY

T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

(2011) Guoyan Cheng et al.   IMMUNOLOGICAL REVIEWS

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

(2011) Joel Montane et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-CD3 Therapy Promotes Tolerance by Selectively Depleting Pathogenic Cells while Preserving Regulatory T Cells

(2011) C. Penaranda et al.   JOURNAL OF IMMUNOLOGY

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

(2011) Stephanie A. McClymont et al.   JOURNAL OF IMMUNOLOGY

Reversal of nonstructural protein 3-specific CD4+ T cell dysfunction in patients with persistent hepatitis C virus infection

(2011) M. Bes et al.   JOURNAL OF VIRAL HEPATITIS

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Understanding type 1 diabetes through genetics: advances and prospects

(2011) Constantin Polychronakos et al.   NATURE REVIEWS GENETICS

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Immune intervention in type 1 diabetes

(2011) Aaron W. Michels et al.   SEMINARS IN IMMUNOLOGY

Regulatory T cells: stability revisited

(2011) Samantha L. Bailey-Bucktrout et al.   TRENDS IN IMMUNOLOGY

Expansion of CD4+CD25+ regulatory T cells from cord blood CD4+ cells using the common γ-chain cytokines (IL-2 and IL-15) and rapamycin

(2010) Shinsuke Asanuma et al.   ANNALS OF HEMATOLOGY

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells

(2010) S A Long et al.   GENES AND IMMUNITY

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

Generation and expansion of regulatory human CD4+ T-cell clones specific for pancreatic islet autoantigens

(2010) James A. Dromey et al.   JOURNAL OF AUTOIMMUNITY

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes

(2010) A. K. Marwaha et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research

(2010) O. S. Burren et al.   NUCLEIC ACIDS RESEARCH

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer

(2010) Todd M. Brusko et al.   PLoS One

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years

(2009) Kevan C. Herold et al.   CLINICAL IMMUNOLOGY

Plasticity of CD4+ FoxP3+ T cells

(2009) Xuyu Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

Adoptive cell therapy for the treatment of patients with metastatic melanoma

(2009) Steven A Rosenberg et al.   CURRENT OPINION IN IMMUNOLOGY

Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice

(2009) M. J. Parker et al.   DIABETES

Is Antigen Specificity of Autoreactive T Cells the Key to Islet Entry?

(2009) Cristina Penaranda et al.   IMMUNITY

T Cell Islet Accumulation in Type 1 Diabetes Is a Tightly Regulated, Cell-Autonomous Event

(2009) Greig P. Lennon et al.   IMMUNITY

T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

(2009) Karen M. Doody et al.   IMMUNOLOGICAL REVIEWS

CD4+regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

(2009) Randall H. Friedline et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

(2008) H. Erlich et al.   DIABETES

PTPN22 Trp620 Explains the Association of Chromosome 1p13 With Type 1 Diabetes and Shows a Statistical Interaction With HLA Class II Genotypes

(2008) D. J. Smyth et al.   DIABETES

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

(2008) Todd M. Brusko et al.   IMMUNOLOGICAL REVIEWS

CTLA-4: a key regulatory point in the control of autoimmune disease

(2008) Kenneth J. Scalapino et al.   IMMUNOLOGICAL REVIEWS

Primary Immune Deficiency Disorders Presenting as Autoimmune Diseases: IPEX and APECED

(2008) D. Moraes-Vasconcelos et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

(2008) Deborah J. Smyth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation

(2008) Volkert A. L. Huurman et al.   PLoS One

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE