Platelets in Multiple Sclerosis: Early and Central Mediators of Inflammation and Neurodegeneration and Attractive Targets for Molecular Imaging and Site-Directed Therapy

Microbiome in Multiple Sclerosis: Where Are We, What We Know and Do Not Know

(2020) Marina Kleopatra Boziki et al.   Brain Sciences

The Gut–CNS Axis in Multiple Sclerosis

(2020) Atsushi Kadowaki et al.   TRENDS IN NEUROSCIENCES

Combined Antiplatelet/Anticoagulant Drug for Cardiac Ischemia/Reperfusion Injury

(2020) Laura A. Bienvenu et al.   CIRCULATION RESEARCH

Metformin as a Potential Agent in the Treatment of Multiple Sclerosis

(2020) Angela Dziedzic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis

(2020) Daiki Takewaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorine‐19 Magnetic Resonance Imaging of Activated Platelets

(2020) Xiaowei Wang et al.   Journal of the American Heart Association

A phase 1, first-in-human study of 18F-GP1 positron emission tomography for imaging acute arterial thrombosis

(2019) Sun Young Chae et al.   EJNMMI Research

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

(2019) Hans Lassmann   Frontiers in Immunology

A Perspective of Coagulation Dysfunction in Multiple Sclerosis and in Experimental Allergic Encephalomyelitis

(2019) Domenico Plantone et al.   Frontiers in Neurology

Pro-Thrombotic Activity of Blood Platelets in Multiple Sclerosis

(2019) Joanna Saluk-Bijak et al.   Cells

Antiphospholipid Antibodies Overlapping in Isolated Neurological Syndrome and Multiple Sclerosis: Neurobiological Insights and Diagnostic Challenges

(2019) Chiara D’Angelo et al.   Frontiers in Cellular Neuroscience

Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis

(2019) Tiago Granja et al.   CRITICAL CARE MEDICINE

Platelet Depletion is Effective in Ameliorating Anxiety-Like Behavior and Reducing the Pro-Inflammatory Environment in the Hippocampus in Murine Experimental Autoimmune Encephalomyelitis

(2019) Pece Kocovski et al.   Journal of Clinical Medicine

The Relationship between Platelet Count and Host Gut Microbiota: A Population-Based Retrospective Cross-Sectional Study

(2019) Hee-Young Yoon et al.   Journal of Clinical Medicine

Impact of B cells to the pathophysiology of multiple sclerosis

(2019) Borros M. Arneth   Journal of Neuroinflammation

The temporal and causal relationship between inflammation and neurodegeneration in multiple sclerosis

(2019) Ron Milo et al.   Multiple Sclerosis Journal

Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

(2018) Milka Koupenova et al.   CIRCULATION RESEARCH

Merits and complexities of modeling multiple sclerosis in non-human primates: implications for drug discovery

(2018) Bert A. ‘t Hart et al.   Expert Opinion on Drug Discovery

Platelets Drive Inflammation and Target Gray Matter and the Retina in Autoimmune-Mediated Encephalomyelitis

(2018) Claretta Sonia D’Souza et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Reassessing B cell contributions in multiple sclerosis

(2018) Rui Li et al.   NATURE IMMUNOLOGY

Multiple Sclerosis: Mechanisms and Immunotherapy

(2018) Clare Baecher-Allan et al.   NEURON

Assessment of Thrombotic Risk in Atrial Fibrillation with Ultrasound Molecular Imaging of P-Selectin

(2018) Hairui Li et al.   THROMBOSIS AND HAEMOSTASIS

Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury

(2018) Marina Dukhinova et al.   BRAIN BEHAVIOR AND IMMUNITY

Multiple sclerosis

(2018) Jiwon Oh et al.   CURRENT OPINION IN NEUROLOGY

A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury

(2017) Melanie Ziegler et al.   EUROPEAN HEART JOURNAL

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

(2017) Wissam Beaino et al.   Journal of Neuroinflammation

18 F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi

(2017) Jessica Lohrke et al.   JOURNAL OF NUCLEAR MEDICINE

Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function

(2017) Daniel Ontaneda et al.   LANCET

Serum neurofilament is associated with progression of brain atrophy and disability in early MS

(2017) Jens Kuhle et al.   NEUROLOGY

A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology

(2017) Bock Lim et al.   Theranostics

Targeting Activated Platelets: A Unique and Potentially Universal Approach for Cancer Imaging

(2017) May Lin Yap et al.   Theranostics

Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens

(2017) Kareem R. Rumah et al.   Frontiers in Cellular and Infection Microbiology

The physiology of blood platelets and changes of their biological activities in multiple sclerosis

(2016) Barbara Wachowicz et al.   ACTA NEUROBIOLOGIAE EXPERIMENTALIS

Multiple sclerosis: experimental models and reality

(2016) Hans Lassmann et al.   ACTA NEUROPATHOLOGICA

Progressive multiple sclerosis: from pathogenic mechanisms to treatment

(2016) Jorge Correale et al.   BRAIN

Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

(2016) Xiaohong Ruby Xu et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Diagnostic Criteria, Classification and Treatment Goals in Multiple Sclerosis: The Chronicles of Time and Space

(2016) Achilles Ntranos et al.   Current Neurology and Neuroscience Reports

Inflammatory Contribution of Platelets Revisited: New Players in the Arena of Inflammation

(2016) Madhumita Chatterjee et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Pathological differences between white and grey matter multiple sclerosis lesions

(2015) Marloes Prins et al.   Annals of the New York Academy of Sciences

Platelets Play Differential Role During the Initiation and Progression of Autoimmune NeuroinflammationNovelty and Significance

(2015) Sarah C. Starossom et al.   CIRCULATION RESEARCH

Ultrasmall superparamagnetic iron oxide nanoparticles coated with fucoidan for molecular MRI of intraluminal thrombus

(2015) Michimasa Suzuki et al.   Nanomedicine

Exploring the origins of grey matter damage in multiple sclerosis

(2015) Massimiliano Calabrese et al.   NATURE REVIEWS NEUROSCIENCE

The role of platelets in inflammation

(2015) Robert Storey et al.   THROMBOSIS AND HAEMOSTASIS

Platelets Are Not Just for Clots

(2015) James D. McFadyen et al.   TRANSFUSION MEDICINE REVIEWS

Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination

(2015) Jennifer R. Linden et al.   mBio

SPECT/CT Imaging of High-Risk Atherosclerotic Plaques using Integrin-Binding RGD Dimer Peptides

(2015) Jung Sun Yoo et al.   Scientific Reports

Detection of High-Risk Atherosclerotic Plaques with Ultrasound Molecular Imaging of Glycoprotein IIb/IIIa Receptor on Activated Platelets

(2015) Shengcun Guo et al.   Theranostics

Hybrid PET/optical imaging of integrin αVβ3 receptor expression using a 64Cu-labeled streptavidin/biotin-based dimeric RGD peptide

(2015) Choong Mo Kang et al.   EJNMMI Research

The inflammatory role of platelets via their TLRs and Siglec receptors

(2015) Fabrice Cognasse   Frontiers in Immunology

T cell mediated pathogenesis in EAE: Molecular mechanisms

(2015) FlorianC Kurschus   Biomedical Journal

Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis

(2014) Matías Sáenz-Cuesta et al.   Biomarkers in Medicine

Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function

(2014) Beatriz Marcos-Ramiro et al.   BMC NEUROSCIENCE

Dual-Contrast Molecular Imaging Allows Noninvasive Characterization of Myocardial Ischemia/Reperfusion Injury After Coronary Vessel Occlusion in Mice by Magnetic Resonance Imaging

(2014) Dominik von Elverfeldt et al.   CIRCULATION

Towards Effective and Safe Thrombolysis and Thromboprophylaxis

(2014) Xiaowei Wang et al.   CIRCULATION RESEARCH

New Multiple Sclerosis Phenotypic Classification

(2014) Fred D. Lublin   EUROPEAN NEUROLOGY

Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron

(2014) Lukas Haider et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Extracellular Vesicles in Multiple Sclerosis: What are They Telling Us?

(2014) Matías Sáenz-Cuesta et al.   Frontiers in Cellular Neuroscience

Experimental autoimmune encephalomyelitis is a good model of multiple sclerosis if used wisely

(2014) David Baker et al.   Multiple Sclerosis and Related Disorders

EAE is not a useful model for demyelinating disease

(2014) Peter O. Behan et al.   Multiple Sclerosis and Related Disorders

Multiple Sclerosis: Molecular Mechanisms and Therapeutic Opportunities

(2013) Djordje Miljković et al.   ANTIOXIDANTS & REDOX SIGNALING

Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

(2013) J. D. Hohmann et al.   BLOOD

Platelets: bridging hemostasis, inflammation, and immunity

(2013) C. N. Jenne et al.   International Journal of Laboratory Hematology

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

Adenosine A2A Receptors in Secondary Progressive Multiple Sclerosis: A [11C]TMSX Brain PET Study

(2013) Eero Rissanen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation

(2013) Ilya Sotnikov et al.   PLoS One

Novel Single-Chain Antibody-Targeted Microbubbles for Molecular Ultrasound Imaging of Thrombosis

(2012) Xiaowei Wang et al.   CIRCULATION

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2012) Harald F. Langer et al.   CIRCULATION RESEARCH

Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism

(2012) Hugo Gonzalo et al.   JOURNAL OF NEUROCHEMISTRY

Animal models of multiple sclerosis: the good, the bad and the bottom line

(2012) Richard M Ransohoff   NATURE NEUROSCIENCE

Will the real multiple sclerosis please stand up?

(2012) Peter K. Stys et al.   NATURE REVIEWS NEUROSCIENCE

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Radiolabeled Cyclic RGD Peptides as Radiotracers for Imaging Tumors and Thrombosis by SPECT

(2012) Yang Zhou et al.   Theranostics

Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more

(2012) Marie Cathrin Mayer et al.   Therapeutic Advances in Neurological Disorders

Unique B cell responses in B cell-dependent and B cell-independent EAE

(2011) Guorong Liu et al.   AUTOIMMUNITY

Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis

(2011) Laura Lovato et al.   BRAIN

A novel mitochondrial DNA deletion producing progressive external ophthalmoplegia associated with multiple sclerosis

(2011) M. Slee et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Radiolabeled Fucoidan as a P-Selectin Targeting Agent for In Vivo Imaging of Platelet-Rich Thrombus and Endothelial Activation

(2011) F. Rouzet et al.   JOURNAL OF NUCLEAR MEDICINE

Critical appraisal of animal models of multiple sclerosis

(2011) David Baker et al.   Multiple Sclerosis Journal

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ultrasound molecular imaging of arterial thrombi with novel microbubbles modified by cyclic RGD in vitro and in vivo

(2011) G. Hu et al.   THROMBOSIS AND HAEMOSTASIS

EAE: imperfect but useful models of multiple sclerosis

(2011) Bert A. ’t Hart et al.   TRENDS IN MOLECULAR MEDICINE

Experimental in vivo and in vitro models of multiple sclerosis: EAE and beyond

(2011) Markus Kipp et al.   Multiple Sclerosis and Related Disorders

Magnetic Resonance Molecular Imaging of Thrombosis in an Arachidonic Acid Mouse Model Using an Activated Platelet Targeted Probe

(2010) Ahmed Klink et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phosphatidylglucoside: a novel marker for adult neural stem cells

(2010) Jun Kaneko et al.   JOURNAL OF NEUROCHEMISTRY

Role of platelets in neuroinflammation: a wide-angle perspective

(2010) Lawrence L Horstman et al.   Journal of Neuroinflammation

Animal models of multiple sclerosis—Potentials and limitations

(2010) Eilhard Mix et al.   PROGRESS IN NEUROBIOLOGY

Axonal and neuronal pathology in multiple sclerosis: What have we learnt from animal models

(2009) Hans Lassmann   EXPERIMENTAL NEUROLOGY

Activities of the enzymes that hydrolyze adenine nucleotides in platelets from multiple sclerosis patients

(2009) Roselia Maria Spanevello et al.   JOURNAL OF NEUROLOGY

Demyelination, Inflammation, and Neurodegeneration in Multiple Sclerosis Deep Gray Matter

(2009) Marco Vercellino et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Pediatric multiple sclerosis

(2009) E. Ann Yeh et al.   Nature Reviews Neurology

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Platelets: Inflammatory Firebugs of Vascular Walls

(2008) Andreas E. May et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Magnetic Resonance Imaging Contrast Agent Targeted Toward Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis

(2008) C. von zur Muhlen et al.   CIRCULATION

Evidence of platelet activation in multiple sclerosis

(2008) William A Sheremata et al.   Journal of Neuroinflammation

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

MRI in multiple sclerosis: current status and future prospects

(2008) Rohit Bakshi et al.   LANCET NEUROLOGY

Spinal cord grey matter lesions in multiple sclerosis detected by post-mortem high field MR imaging

(2008) CP Gilmore et al.   Multiple Sclerosis Journal

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE

Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments

(2008) Ruth Huizinga et al.   NEUROBIOLOGY OF DISEASE