Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

Zebrafish model of posttraumatic epilepsy

(2020) Sung‐Joon Cho et al.   EPILEPSIA

Functional and behavioral signatures of Kv7 activator drug subtypes

(2020) Richard Kanyo et al.   EPILEPSIA

Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein

(2020) Richard Kanyo et al.   EXPERIMENTAL NEUROLOGY

A systematic review of closed head injury models of mild traumatic brain injury in mice and rats

(2019) Colleen N Bodnar et al.   JOURNAL OF NEUROTRAUMA

Mild closed head injury in conscious rats causes transient neurobehavioral and glial disturbances: A novel experimental model of concussion

(2019) Louise Pham et al.   JOURNAL OF NEUROTRAUMA

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo

(2019) Frederik J. Verweij et al.   DEVELOPMENTAL CELL

A mouse model of repetitive blast traumatic brain injury reveals post-trauma seizures and increased neuronal excitability

(2019) Vladislav Bugay et al.   JOURNAL OF NEUROTRAUMA

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

(2019) Morvane Colin et al.   ACTA NEUROPATHOLOGICA

Prion-like Spreading in Tauopathies

(2018) Jacob I. Ayers et al.   BIOLOGICAL PSYCHIATRY

OUP accepted manuscript

(2018)   BRAIN

Tau-Induced Pathology in Epilepsy and Dementia: Notions from Patients and Animal Models

(2018) Marina Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prion gene paralogs are dispensable for early zebrafish development but have non-additive roles in seizure susceptibility

(2018) Patricia L.A. Leighton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Population genetic diversity in zebrafish lines

(2018) Michele Balik-Meisner et al.   MAMMALIAN GENOME

Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats

(2018) Alicia Meconi et al.   PLoS One

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

TRANSCELLULAR SPREADING OF TAU IN TAUOPATHIES

(2018) Koen Demaegd et al.   CHEMBIOCHEM

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells

(2018) Edward Pokrishevsky et al.   Scientific Reports

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

A Novel Model of Traumatic Brain Injury in Adult Zebrafish Demonstrates Response to Injury and Treatment Comparable with Mammalian Models

(2017) Victoria McCutcheon et al.   JOURNAL OF NEUROTRAUMA

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

(2017) Ghazaleh Eskandari-Sedighi et al.   Molecular Neurodegeneration

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

(2017) Eleanor K. Pickett et al.   SYNAPSE

A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

(2017) Miranda E. Orr et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

4-dimensional functional profiling in the convulsant-treated larval zebrafish brain

(2017) Matthew J. Winter et al.   Scientific Reports

Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

(2017) Marcela Cruz-Haces et al.   Translational Neurodegeneration

What is the evidence that tau pathology spreads through prion-like propagation?

(2017) Amrit Mudher et al.   Acta Neuropathologica Communications

Chronic Traumatic Encephalopathy: The Neuropathological Legacy of Traumatic Brain Injury

(2016) Jennifer Hay et al.   Annual Review of Pathology-Mechanisms of Disease

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections

(2016) Xin You Tai et al.   BRAIN

Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy

(2016) Vikram Puvenna et al.   BRAIN RESEARCH

The International Incidence of Traumatic Brain Injury: A Systematic Review and Meta-Analysis

(2016) Rita Nguyen et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy?

(2016) Patricia M. Washington et al.   EXPERIMENTAL NEUROLOGY

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers

(2016) Joseph O. Ojo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Transition from Initial Hypoactivity to Hyperactivity in Cortical Layer V Pyramidal Neurons after Traumatic Brain InjuryIn Vivo

(2016) Xingjie Ping et al.   JOURNAL OF NEUROTRAUMA

Dynamin Functions and Ligands: Classical Mechanisms Behind

(2016) Mahaveer Singh et al.   MOLECULAR PHARMACOLOGY

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells

(2016) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Model of Excitotoxic Brain Injury in Larval Zebrafish: Potential Application for High-Throughput Drug Evaluation to Treat Traumatic Brain Injury

(2016) Victoria McCutcheon et al.   Zebrafish

Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus

(2016) David Hanwell et al.   Zebrafish

4-Аminopyridine sequesters intracellular Ca2+ which triggers exocytosis in excitable and non-excitable cells

(2016) Ludmila A. Kasatkina   Scientific Reports

Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections

(2015) Michiyo Iba et al.   ACTA NEUROPATHOLOGICA

The Neuropathology of Chronic Traumatic Encephalopathy

(2015) Ann C. McKee et al.   BRAIN PATHOLOGY

Neuronal Aggregates: Formation, Clearance, and Spreading

(2015) Junghyun Lim et al.   DEVELOPMENTAL CELL

Traumatic Brain Injury and Psychogenic Seizures in Veterans

(2015) Martin Salinsky et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Epidemiology of mild traumatic brain injury and neurodegenerative disease

(2015) Raquel C. Gardner et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

(2015) Eve Peeraer et al.   NEUROBIOLOGY OF DISEASE

Labeling of active neural circuits in vivo with designed calcium integrators

(2015) B. F. Fosque et al.   SCIENCE

Traumatic brain injury and epilepsy: Underlying mechanisms leading to seizure

(2015) Brandon P. Lucke-Wold et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Seizures and Epilepsy: An Overview for Neuroscientists

(2015) C. E. Stafstrom et al.   Cold Spring Harbor Perspectives in Medicine

Seizures and Traumatic Brain Injury

(2014) Jeffrey Englander et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

gdf6a Is Required for Cone Photoreceptor Subtype Differentiation and for the Actions of tbx2b in Determining Rod Versus Cone Photoreceptor Fate

(2014) Michèle G. DuVal et al.   PLoS One

Tolerance to seizure induced by kainic acid is produced in a specific period of zebrafish development

(2014) Fabiano Peres Menezes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

(2014) Richelle Mychasiuk et al.   Jove-Journal of Visualized Experiments

Blast TBI Models, Neuropathology, and Implications for Seizure Risk

(2014) S. Krisztian Kovacs et al.   Frontiers in Neurology

Pyrimidyn Compounds: Dual-Action Small Molecule Pyrimidine-Based Dynamin Inhibitors

(2013) Andrew B. McGeachie et al.   ACS Chemical Biology

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

(2013) Victoria E. Johnson et al.   BRAIN

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis

(2013) Adam McCluskey et al.   TRAFFIC

Distinct models of induced hyperactivity in zebrafish larvae

(2012) Lee David Ellis et al.   BRAIN RESEARCH

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of variable blast pressures on blood flow and oxygen saturation in rat brain as evidenced using MRI

(2012) Cynthia Bir et al.   MAGNETIC RESONANCE IMAGING

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice

(2012) Xiao-Xin Yan et al.   PLoS One

Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study

(2011) Maria Thom et al.   BRAIN

Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans

(2011) Victoria E. Johnson et al.   BRAIN PATHOLOGY

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Primary Blast-Induced Traumatic Brain Injury: Insights from Shock-Wave Research

(2011) Atsuhiro Nakagawa et al.   JOURNAL OF NEUROTRAUMA

Reduced neuronal proliferation by proconvulsant drugs in the developing zebrafish brain

(2010) Yeon-Hwa Kim et al.   NEUROTOXICOLOGY AND TERATOLOGY

Zebrafish Brain Ventricle Injection

(2009) Jennifer H. Gutzman et al.   Jove-Journal of Visualized Experiments

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell