Review
Biochemistry & Molecular Biology
Anastasia A. Vasilieva, Elena E. Timechko, Kristina D. Lysova, Anastasia I. Paramonova, Alexey M. Yakimov, Elena A. Kantimirova, Diana V. Dmitrenko
Summary: Structural or post-traumatic epilepsy often develops after brain tissue damage caused by traumatic brain injury, stroke, infections of the brain, etc. MicroRNAs, such as miR-21, miR-181a, and miR-155, show potential as biomarkers for predicting epileptogenesis. However, more in-depth and prolonged studies are needed to understand the process of epileptogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jie Wang, Xiaoyang Chai, Fang Zhang, Yuchen Li, Huijun Shen, Keyi Lu
Summary: The reduced level of neuronal autophagy during the latency period may be a possible mechanism for the increased susceptibility to post-traumatic epilepsy (PTE) after mild traumatic brain injury (mTBI). The study used a rat model to simulate mTBI and observed the extent of injury and the incidence of epilepsy. The results showed that the incidence of PTE was higher after mTBI, and the level of autophagy was reduced during the latency period. Administration of the autophagy agonist rapamycin significantly reduced the incidence of PTE.
NEUROCHEMICAL RESEARCH
(2023)
Article
Clinical Neurology
Yilun Chen, Songlu Li, Wendong Ge, Jin Jing, Hsin Yi Chen, Daniel Doherty, Alison Herman, Safa Kaleem, Kan Ding, Gamaleldin Osman, Christa B. Swisher, Christine Smith, Carolina B. Maciel, Ayham Alkhachroum, Jong Woo Lee, Monica B. Dhakar, Emily J. Gilmore, Adithya Sivaraju, Lawrence J. Hirsch, Sacit B. Omay, Hal Blumenfeld, Kevin N. Sheth, Aaron F. Struck, Brian L. Edlow, M. Brandon Westover, Jennifer A. Kim
Summary: This study evaluated the contribution of quantitative electroencephalograms in predicting post-traumatic epilepsy (PTE) and found that these features enhance the predictive value of PTE1, especially when combined with TBI mechanism and CT abnormalities. Future research should validate these findings.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
C. Mele, L. Pagano, D. Franciotta, M. Caputo, A. Nardone, G. Aimaretti, P. Marzullo, V. Pingue
Summary: Thyroid hormones may play a role in triggering seizures in patients with traumatic brain injury. Serum fT3 levels are associated with the risk of post-traumatic seizures and functional outcome in TBI patients. Further research is needed to explore the underlying mechanisms of these associations.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Clinical Neurology
Eppu Manninen, Karthik Chary, Niina Lapinlampi, Pedro Andrade, Tomi Paananen, Alejandra Sierra, Jussi Tohka, Olli Grohn, Asla Pitkanen
Summary: This study aimed to identify MRI biomarkers for post-traumatic epilepsy in Sprague-Dawley rats with traumatic brain injury. The researchers found that a combination of T-2 relaxation time and diffusion tensor data could distinguish rats with and without epilepsy, and even a single time-point measurement could significantly enrich the epilepsy rate within the study population.
Review
Clinical Neurology
Lei Sun, Wei Shan, Huajun Yang, Ru Liu, Jianping Wu, Qun Wang
Summary: Post-traumatic epilepsy is a serious consequence of traumatic brain injury, and inflammation plays a significant role in epileptogenesis. Understanding the contribution of neuroinflammation to the development of PTE is crucial, requiring further research.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Irma Wati Ngadimon, Angel Aledo-Serrano, Alina Arulsamy, Devi Mohan, Ching Soong Khoo, Wing Loong Cheong, Mohd. Farooq Shaikh
Summary: This systematic review examines the relationship between PTE and cognitive impairment in TBI patients and suggests a possible link between the two. However, due to variations in sample sizes, follow-up periods, and assessment tools, the interpretation and significance of this relationship are limited.
FRONTIERS IN NEUROLOGY
(2022)
Review
Endocrinology & Metabolism
Prince Kumar
Summary: Traumatic brain injury (TBI) and post-traumatic epilepsy (PTE) share similar molecular mechanisms, and dysregulation of microRNAs (miRNAs) in both conditions has been reported. This systematic review analyzed research articles and database studies to identify commonly dysregulated miRNAs in TBI and epilepsy. The study found 85 and 222 dysregulated miRNAs in TBI and epilepsy respectively, with 10 miRNAs commonly dysregulated. These findings may help identify potential biomarkers for PTE.
METABOLIC BRAIN DISEASE
(2023)
Article
Cell Biology
Erwin Kristobal Gudenschwager-Basso, Oleksii Shandra, Troy Volanth, Dipan C. C. Patel, Colin Kelly, Jack L. L. Browning, Xiaoran Wei, Elizabeth A. A. Harris, Dzenis Mahmutovic, Alexandra M. M. Kaloss, Fernanda Guilhaume Correa, Jeremy Decker, Biswajit Maharathi, Stefanie Robel, Harald Sontheimer, Pamela J. J. VandeVord, Michelle L. L. Olsen, Michelle H. H. Theus
Summary: Background: Traumatic brain injury (TBI) is a significant risk factor for post-traumatic epilepsy (PTE), and the dentate gyrus has been implicated in seizure development. Methods: Using murine models, seizure onset and cellular changes in the dentate gyrus and hippocampus were evaluated at 2-4 months after TBI. Isolation of region-specific astrocytes and RNA-Seq were performed for differential gene expression analysis. Results: TBI led to PTE with increased severity and hippocampal damage. Histological assessments revealed aberrant cell migration and reduced astroglial branching in PTE+ mice. Cst3 was identified as a PTE+-specific gene in astrocytes. Conclusions: Cellular remodeling and molecular changes in the dentate gyrus may contribute to epileptogenesis following TBI.
Article
Critical Care Medicine
Mary Jo Pugh, Eamonn Kennedy, James J. Gugger, Jamie Mayo, David Tate, Alicia Swan, Jacob Kean, Hamada Altalib, Shaila Gowda, Alan Towne, Sidney Hinds, Anne Van Cott, Maria R. Lopez, Carlos A. Jaramillo, Blessen C. Eapen, Randall R. McCafferty, Martin Salinsky, Joyce Cramer, Katherine K. McMillan, Andrea Kalvesmaki, Ramon Diaz-Arrastia
Summary: Understanding the risk of epilepsy among those who experience mild traumatic brain injury (mTBI) is crucial for intervention and prevention, yet these cases are often undocumented in health records and pose challenges in population-based assessments. The MINUTE study revealed high rates of undocumented lifetime TBIs among veterans with epilepsy, highlighting the impact of epilepsy combined with TBI on physical functioning and health-related quality of life.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Behavioral Sciences
Jesus-Servando Medel-Matus, Carra A. Simpson, Aaron I. Ahdoot, Don Shin, Raman Sankar, Jonathan P. Jacobs, Andrey M. Mazarati
Summary: It has been established that traumatic brain injury affects the composition of gut microbiota, and epilepsy, as a common sequela of TBI, has been associated with dysbiosis. This study investigated the impact of fecal microbiota transfer (FMT) from rats with different prospective histories of post-traumatic epilepsy (PTE) on the trajectory of PTE in recipients. The findings showed that FMT from donors with impending PTE exerted mild-to-moderate pro-epileptic effects in recipients.
EPILEPSY & BEHAVIOR
(2022)
Review
Clinical Neurology
Jinn-Rung Kuo, Bei-Yi Su
Summary: The research on the prognosis of neuropsychological function in patients with post-traumatic seizures (PTE) is limited. This study systematically reviewed the literature on PTE and neuropsychological impairments, and found that PTE patients may have impairments in neuropsychological function. More attention should be given to older patients and those with higher brain injury and seizure severity.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Tingting Yu, Xiao Liu, Lei Sun, Ruijuan Lv, Jianping Wu, Qun Wang
Summary: This study aims to use clinical data to predict the functional outcomes of patients with PTE after moderate-to-severe TBI, in order to develop accurate rehabilitation programs and improve their quality of life.
FRONTIERS IN NEUROLOGY
(2022)
Article
Critical Care Medicine
Sung-Joon Cho, Eugene Park, Andrew Baker, Aylin Y. Reid
Summary: This study used a zebrafish model to investigate the cognitive impairments of post-traumatic epilepsy (PTE) and analyzed the pharmacological effects of the most commonly used anti-seizure medications. The findings indicated that zebrafish with PTE exhibited learning and memory impairments, decision-making difficulties, and reduced social preference.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Matthew Pease, Jonathan Elmer, Ameneh Zare Shahabadi, Arka N. Mallela, Juan F. Ruiz-Rodriguez, Daniel Sexton, Niravkumar Barot, Jorge A. Gonzalez-Martinez, Lori Shutter, David O. Okonkwo, James F. Castellano
Summary: By analyzing early electroencephalographic (EEG) features, it is possible to identify patients at high risk for posttraumatic epilepsy (PTE) in severe traumatic brain injury (TBI) cases. Quantitative EEG (qEEG) analysis showed that PTE patients had higher spectral power and power variance in the delta frequencies, as well as higher peak envelope. These findings have significant implications for early clinical management and patient selection in clinical trials.
Article
Integrative & Complementary Medicine
Zhao Ji-meng, Lu Jin-hua, Yin Xiao-jun, Chen Xing-kui, Chen Yue-hua, Tang Wei-jun, Jin Xiao-ming, Wu Lu-yi, Bao Chun-hui, Wu Huan-gan, Shi Yin
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2015)
Article
Gastroenterology & Hepatology
Chun Hui Bao, Peng Liu, Hui Rong Liu, Lu Yi Wu, Yin Shi, Wei Feng Chen, Wei Qin, Yuan Lu, Jian Ye Zhang, Xiao Ming Jin, Xiao Mei Wang, Ji Meng Zhao, Xiao Ming Liu, Jie Tian, Huan Gan Wu
JOURNAL OF CROHNS & COLITIS
(2015)
Article
Neurosciences
Lingxiao Deng, Yiwen Ruan, Chen Chen, Christian Corbin Frye, Wenhui Xiong, Xiaoming Jin, Kathryn Jones, Dale Sengelaub, Xiao-Ming Xu
EXPERIMENTAL NEUROLOGY
(2016)
Article
Neurosciences
Keming Ren, Lijuan Chen, Guoxia Sheng, Jiangping Wang, Xiaoming Jin, Kewen Jiang
NEUROSCIENCE LETTERS
(2016)
Article
Anesthesiology
Chun-Hui Bao, Peng Liu, Hui-Rong Liu, Lu-Yi Wu, Xiao-Ming Jin, Si-Yao Wang, Yin Shi, Jian-Ye Zhang, Xiao-Qing Zeng, Li-Li Ma, Wei Qin, Ji-Meng Zhao, Vince D. Calhoun, Jie Tian, Huan-Gan Wu
Article
Multidisciplinary Sciences
Xingjie Ping, Xiaoming Jin
Article
Cell & Tissue Engineering
Lan Fang, Jun Zhang, Hui Zhang, Xiaoqin Yang, Xueling Jin, Ling Zhang, David G. Skalnik, Ying Jin, Yong Zhang, Xingxu Huang, Jiwen Li, Jiemin Wong
Article
Medicine, General & Internal
Lifang Chen, Jianqiao Fang, Xiaoming Jin, Crystal Lynn Keeler, Hong Gao, Zhen Fang, Qin Chen
Article
Multidisciplinary Sciences
Wei Wu, Wenhui Xiong, Ping Zhang, Lifang Chen, Jianqiao Fang, Christopher Shields, Xiao-Ming Xu, Xiaoming Jin
Article
Biochemistry & Molecular Biology
Daniel E. Knutson, Jodi L. Smith, Xingjie Ping, Xiaoming Jin, Lalit K. Golani, Guanguan Li, V. V. N. Phani Babu Tiruveedhula, Farjana Rashid, Md Yeunus Mian, Rajwana Jahan, Dishary Sharmin, Rok Cerne, James M. Cook, Jeffrey M. Witkin
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Xingjie Ping, Zhi Chai, Weiping Wang, Cungen Ma, Fletcher F. A. White, Xiaoming Jin
Summary: Blocking RAGE and TLR4 signaling pathways significantly increased seizure threshold, reduced spontaneous seizure events, increased neuronal and inhibitory interneuron densities in the lesioned cortex, and decreased astrocyte and microglia densities in the treatment groups, suggesting a potential strategy for preventing posttraumatic epilepsy.
Article
Biochemistry & Molecular Biology
Xingjie Ping, Junkai Xie, Chongli Yuan, Xiaoming Jin
Summary: Clinical and animal studies have shown that acupuncture may be beneficial in controlling neuropathic pain, but the underlying molecular mechanisms are poorly understood. In a mouse model of tibial nerve injury, electroacupuncture (EA) was found to reduce mechanical allodynia and affect the methylation and hydroxy-methylation levels in different cortical regions involved in pain processing. RNA sequencing identified differentially expressed genes related to energy metabolism, inflammation, synapse function, and neural plasticity and repair in these regions, and EA was found to regulate the expression of these genes. These findings suggest that the analgesic effect of EA may involve epigenetic regulation of gene expression in the cortex.
Article
Endocrinology & Metabolism
Tao Pan, Qi Xiao, Hui-Jie Fan, Lei Xu, Shao-Chen Qin, Li-Xia Yang, Xiao-ming Jin, Bao-Guo Xiao, Bo Zhang, Cun-Gen Ma, Zhi Chai
Summary: This study demonstrates the therapeutic effects of Wuzi Yanzong Pill (WYP) on Parkinson's disease, by inhibiting neuroinflammation and protecting dopaminergic neurons. The study also suggests that WYP may exert its anti-inflammatory effects through modulation of the NLRP3 inflammasome and TLR4/MyD88/NF-kappa B pathway.
METABOLIC BRAIN DISEASE
(2023)
Article
Clinical Neurology
Yadav Adhikari, Xiaoming Jin