Article
Clinical Neurology
Masen L. Boucher, Grace Conley, Jordan Nowlin, Jianhua Qiu, Keisuke Kawata, Jeffrey J. Bazarian, William P. Meehan, Rebekah Mannix
Summary: Recently, there has been increasing attention in the scientific community to the phenomenon of sub-concussive impacts, which are hits to the head that don't cause symptoms of a concussion. This study used a mouse model to investigate the effects of low-level repetitive head impacts. The results showed that even without noticeable behavioral changes, the impacts caused pathology in the brain, as well as downregulation of inflammatory pathways.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Saef Izzy, Alexander Brown-Whalen, Taha Yahya, Aliyah Sarro-Schwartz, Gina Jin, Joon Yong Chung, Sevda Lule, Liza M. Morsett, Ali Alquraini, Limin Wu, Suzanne E. Hickman, Michael J. Whalen, Joseph El Khoury
Summary: The study found that repetitive closed head injury (rCHI) did not accelerate tau pathology and did not worsen behavioral outcomes in adolescent mice. However, rCHI induced microgliosis in the cortex and hippocampus and astrocytosis in the corpus callosum of P301S mice by 40 days post-injury. There were no significant microgliosis or astrocytosis observed in age-matched WT mice or sham-injured P301S mice after rCHI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Claire Kostelnik, Irwin Lucki, Kwang H. Choi, Caroline A. Browne
Summary: This review outlines the increased risk of PTSD following mTBI in military populations and emphasizes the importance of establishing translationally relevant animal models. It also evaluates the translational relevance of fear conditioning paradigms and addresses the lack of research on fear memory enhancement over time post mTBI. Additionally, potential neurobiological substrates implicated in altered fear memory post mTBI are discussed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Veterinary Sciences
Samantha J. Murray, Nadia L. Mitchell
Summary: The use of sheep as models for human neurological disorders has significantly increased in the past two decades. Sheep have several advantages over small animal models when it comes to studying the brain, including a size and structure more comparable to the human brain. They also have longer life spans and are docile animals, making them useful for various in vivo studies. Sheep can easily be subjected to regular blood and cerebrospinal fluid sampling, aiding in biomarker discovery and treatment efficacy monitoring. They naturally develop several neurological diseases, and can also be genetically engineered or experimentally manipulated to replicate diseases or injuries. Many sheep models are currently being used for pre-clinical therapeutic trials, particularly gene therapy, with promising results moving into clinical trials.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Emergency Medicine
Sean C. Rose, Deborah A. Levine, Junxin Shi, Krista Wheeler, Taylour Aungst, Rachel M. Stanley, Miriam H. Beauchamp
Summary: This study examined the incidence and healthcare utilization of mild traumatic brain injury (mTBI) in young children presenting to U.S. emergency departments. The findings showed that early childhood mTBI is prevalent and results in a significant financial burden. There is wide variation in diagnostic coding and treatment strategies among emergency departments, highlighting the need for further research.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Daniel H. Daneshvar, Evan S. Nair, Zachary H. Baucom, Abigail Rasch, Bobak Abdolmohammadi, Madeline Uretsky, Nicole Saltiel, Arsal Shah, Johnny Jarnagin, Christine M. Baugh, Brett M. Martin, Joseph N. Palmisano, Jonathan D. Cherry, Victor E. Alvarez, Bertrand R. Huber, Jennifer Weuve, Christopher J. Nowinski, Robert C. Cantu, Ross D. Zafonte, Brigid Dwyer, John F. Crary, Lee E. Goldstein, Neil W. Kowall, Douglas I. Katz, Robert A. Stern, Yorghos Tripodis, Thor D. Stein, Michael D. McClean, Michael L. Alosco, Ann C. McKee, Jesse Mez
Summary: Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI). The relationship between the components of RHI exposure and CTE pathology remains unclear. Using American football helmet sensor data, this study finds that duration of play, cumulative head impacts, and linear and rotational accelerations are significantly associated with CTE pathology.
NATURE COMMUNICATIONS
(2023)
Article
Behavioral Sciences
Fanny Degeilh, Tilmann von Soest, Lia Ferschmann, Joanne C. Beer, Malo Gaubert, Inga K. Koerte, Christian K. Tamnes
Summary: Childhood mTBI is associated with an increased risk of developing social problems, possibly due to changes in the structural development of the social brain. This study used data from the ABCD Study to examine the development of social problems and cortical thickness in social brain regions following childhood mTBI. The findings showed different developmental trajectories in social problems between children with and without mTBI, with the mTBI group showing higher levels of social problems. Both groups showed similar decreases in social brain cortical thickness.
Review
Biochemistry & Molecular Biology
Alesa H. Netzley, Galit Pelled
Summary: In recent years, pigs have gained attention as an important model animal for studying human neuroanatomy, physiology, and behavior. Their high intelligence and ability to perform various behaviors make them valuable in understanding neurological conditions. Pigs have particularly emerged as a relevant species for studying traumatic brain injury. The use of pigs in cognitive and behavioral research, as well as physiological assessment, is discussed in this review.
Article
Neurosciences
Rita Campos-Pires, Bee Eng Ong, Mariia Koziakova, Eszter Ujvari, Isobel Fuller, Charlotte Boyles, Valerie Sun, Andy Ko, Daniel Pap, Matthew Lee, Lauren Gomes, Kate Gallagher, Peter F. Mahoney, Robert Dickinson
Summary: This study investigates the effects of repeated mild blast traumatic brain injury (mbTBI) on rats and identifies specific brain regions that are particularly sensitive to repeated blast exposure. The findings suggest that repeated exposure to blast can lead to functional impairments and neuronal loss in certain brain regions. The reasons for this sensitivity may include exposure to stronger shockwaves or proximity to tissue density transitions. This study provides insights into the mechanisms of injury sensitization and potential new treatments.
Review
Sport Sciences
Elena M. Bonke, Julia Southard, Thomas A. Buckley, Claus Reinsberger, Inga K. Koerte, David R. Howell
Summary: This systematic review investigated the association between repetitive head impacts and postural control. The findings were heterogeneous, with a tendency towards no significant effects of repetitive head impacts on clinical postural control measures. Future studies on different athlete populations are needed to further explore the effects of repetitive head impacts.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Review
Biochemistry & Molecular Biology
Yair Shemesh, Alon Chen
Summary: Mental disorders have a significant impact on individuals and society, but current therapies are often ineffective or poorly tolerated. Most novel therapeutic candidates fail in clinical testing, leading to a lack of investment in the field. This raises questions about the use of animal models and their relevance to human mental illnesses. This article argues for the importance of using rodents as animal models and suggests a paradigm shift in behavioral testing methods to better mimic naturalistic environments and behaviors.
MOLECULAR PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Leila L. Etemad, John K. Yue, Jason Barber, Lindsay D. Nelson, Yelena G. Bodien, Gabriela G. Satris, Patrick J. Belton, Debbie Y. Madhok, J. Russell Huie, Sabah Hamidi, Joye X. Tracey, Bukre C. Coskun, Justin C. Wong, Esther L. Yuh, Pratik Mukherjee, Amy J. Markowitz, Michael C. Huang, Phiroz E. Tarapore, Claudia S. Robertson, Ramon Diaz-Arrastia, Murray B. Stein, Adam R. Ferguson, Ava M. Puccio, David O. Okonkwo, Joseph T. Giacino, Michael A. Mccrea, Geoffrey T. Manley, Nancy R. Temkin, Anthony M. Digiorgio
Summary: This study investigated the association between subsequent traumatic brain injuries (TBIs) and multidimensional outcomes at 1 year and 3 to 7 years. The results showed that postindex TBIs were associated with worse functional recovery, health-related quality of life, and various psychological symptoms. These associations remained significant at the 3 to 7-year follow-up. Individuals who experienced multiple postindex TBIs had poorer outcomes in all domains.
Article
Orthopedics
Robert C. Lynall, Christopher D'Lauro, Zachary Y. Kerr, Kristen Knight, Emily Kroshus, Daniel D. Leeds, Johna K. Register-Mihalik, Michael McCrea, Steven P. Broglio, Thomas McAllister, Julianne D. Schmidt
Summary: The study aimed to investigate the association between previous concussion diagnosis status and outcomes on standard baseline concussion assessments. The results showed that individuals with a history of undiagnosed concussions performed worse on baseline clinical indicators.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Orthopedics
Julianne D. Schmidt, Steven P. R. Broglio, Kristen G. Knight, Daniel Leeds, Robert T. Lynall, Christopher P. D'Lauro, Johna Register-Mihalik, Emily Kroshus, Michael McCrea, Tom McAllister, Zachary Kerr
Summary: About half of concussions go undisclosed and delayed medical care is common. Delayed reporting of concussion symptoms leads to higher symptom burdens and longer recovery time.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Review
Neurosciences
Emily L. Dennis, David Baron, Brenda Bartnik-Olson, Karen Caeyenberghs, Carrie Esopenko, Frank G. Hillary, Kimbra Kenney, Inga K. Koerte, Alexander P. Lin, Andrew R. Mayer, Stefania Mondello, Alexander Olsen, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) is a leading cause of global disability, but predicting patient outcomes is challenging due to the heterogeneous nature of TBI in terms of injury severity and other factors. Neuroimaging research has been limited by small sample sizes, and the development of reliable biomarkers for mild TBI or repeated subconcussive impacts has been slow.
HUMAN BRAIN MAPPING
(2022)
Article
Pathology
Denise I. Briggs, Mariana Angoa-Perez, Donald M. Kuhn
AMERICAN JOURNAL OF PATHOLOGY
(2016)
Article
Multidisciplinary Sciences
Bitna Yi, Alam Jahangir, Andrew K. Evans, Denise Briggs, Kristine Ravina, Jacqueline Ernest, Amir B. Farimani, Wenchao Sun, Jayakumar Rajadas, Michael Green, Evan N. Feinberg, Vijay S. Pande, Mehrdad Shamloo
Article
Biochemistry & Molecular Biology
Mariana Angoa-Perez, Michael J. Kane, Denise I. Briggs, Nieves Herrera-Mundo, Catherine E. Sykes, Dina M. Francescutti, Donald M. Kuhn
ACS CHEMICAL NEUROSCIENCE
(2014)
Article
Biochemistry & Molecular Biology
Mariana Angoa-Perez, Michael J. Kane, Denise I. Briggs, Catherine E. Sykes, Mrudang M. Shah, Dina M. Francescutti, David R. Rosenberg, David M. Thomas, Donald M. Kuhn
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Mariana Angoa-Perez, Michael J. Kane, Denise I. Briggs, Dina M. Francescutti, Catherine E. Sykes, Mrudang M. Shah, David M. Thomas, Donald M. Kuhn
JOURNAL OF NEUROCHEMISTRY
(2013)
Review
Biochemistry & Molecular Biology
Mariana Angoa-Perez, Michael J. Kane, Denise I. Briggs, Nieves Herrera-Mundo, David C. Viano, Donald M. Kuhn
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Biochemical Research Methods
Michael J. Kane, Mariana Angoa-Perez, Denise I. Briggs, David C. Viano, Christian W. Kreipke, Donald M. Kuhn
JOURNAL OF NEUROSCIENCE METHODS
(2012)
Article
Neurosciences
Michael J. Kane, Mariana Angoa-Perez, Dina M. Francescutti, Catherine E. Sykes, Denise I. Briggs, Lai Yee Leung, Pamela J. VandeVord, Donald M. Kuhn
NEUROSCIENCE LETTERS
(2012)
Article
Multidisciplinary Sciences
Michael J. Kane, Mariana Angoa-Perez, Denise I. Briggs, Catherine E. Sykes, Dina M. Francescutti, David R. Rosenberg, Donald M. Kuhn
Article
Biochemistry & Molecular Biology
Kristine Ravina, Denise I. Briggs, Sezen Kislal, Zuha Warraich, Tiffany Nguyen, Rachel K. Lam, Thomas I. Zarembinski, Mehrdad Shamloo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Neurosciences
Denise Isabelle Briggs, Erwin Defensor, Pooneh Memar Ardestani, Bitna Yi, Michelle Halpain, Guy Seabrook, Mehrdad Shamloo