Impact of Food Additive Titanium Dioxide on Gut Microbiota Composition, Microbiota-Associated Functions, and Gut Barrier: A Systematic Review of In Vivo Animal Studies

Titanium dioxide nanoparticles via oral exposure leads to adverse disturbance of gut microecology and locomotor activity in adult mice

(2020) Shanshan Zhang et al.   ARCHIVES OF TOXICOLOGY

Acute high‐dose titanium dioxide nanoparticle exposure alters gastrointestinal homeostasis in mice

(2020) Courtney C. Kurtz et al.   JOURNAL OF APPLIED TOXICOLOGY

TiO 2 Nanoparticles and Commensal Bacteria Alter Mucus Layer Thickness and Composition in a Gastrointestinal Tract Model

(2020) Rhodesherdeline Limage et al.   Small

Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health

(2020) Bruno Lamas et al.   Particle and Fibre Toxicology

Foodborne Titanium Dioxide Nanoparticles Induce Stronger Adverse Effects in Obese Mice than Non‐Obese Mice: Gut Microbiota Dysbiosis, Colonic Inflammation, and Proteome Alterations

(2020) Xiaoqiong Cao et al.   Small

Long-term exposure to titanium dioxide nanoparticles promotes diet-induced obesity through exacerbating intestinal mucus layer damage and microbiota dysbiosis

(2020) Xiaoqiang Zhu et al.   Nano Research

Food Additives, Gut Microbiota, and Irritable Bowel Syndrome: A Hidden Track

(2020) Emanuele Rinninella et al.   International Journal of Environmental Research and Public Health

Exposure to Titanium Dioxide Nanoparticles During Pregnancy Changed Maternal Gut Microbiota and Increased Blood Glucose of Rat

(2019) Zhilei Mao et al.   Nanoscale Research Letters

Effect of long-term intake of dietary titanium dioxide nanoparticles on intestine inflammation in mice

(2019) wei mu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Exposure to TiO2 nanoparticles induces shifts in the microbiota composition of Mytilus galloprovincialis hemolymph

(2019) Manon Auguste et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Titanium Dioxide Nanoparticles Elicit Lower Direct Inhibitory Effect on Human Gut Microbiota Than Silver Nanoparticles

(2019) Richard T Agans et al.   TOXICOLOGICAL SCIENCES

The Gut Microbiota in the First Decade of Life

(2019) Muriel Derrien et al.   TRENDS IN MICROBIOLOGY

Intra-amniotic administration (Gallus gallus) of TiO2, SiO2, and ZnO nanoparticles affect brush border membrane functionality and alters gut microflora populations

(2019) Nikolai Kolba et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of TiO2 nanoparticles on intestinal microbial composition of silkworm, Bombyx mori

(2019) Mengxue Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Food Components and Dietary Habits: Keys for a Healthy Gut Microbiota Composition

(2019) Rinninella et al.   Nutrients

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

(2019) Emily R Leeming et al.   Nutrients

Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish

(2018) Lianguo Chen et al.   ENVIRONMENTAL POLLUTION

Titanium dioxide nanoparticle exposure alters metabolic homeostasis in a cell culture model of the intestinal epithelium and Drosophila melanogaster

(2018) Jonathan W. Richter et al.   Nanotoxicology

Food-grade TiO2 is trapped by intestinal mucus in vitro but does not impair mucin O-glycosylation and short-chain fatty acid synthesis in vivo: implications for gut barrier protection

(2018) Pauline Talbot et al.   JOURNAL OF NANOBIOTECHNOLOGY

Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure

(2018) Juan Li et al.   Nanoscale

In vitro intestinal epithelium responses to titanium dioxide nanoparticles

(2018) Paola Pedata et al.   FOOD RESEARCH INTERNATIONAL

Impact of food grade and nano-TiO 2 particles on a human intestinal community

(2017) William Dudefoi et al.   FOOD AND CHEMICAL TOXICOLOGY

Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice

(2017) Fashui Hong et al.   International Journal of Nanomedicine

Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress

(2017) Marie Dorier et al.   Nanotoxicology

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

(2017) Sarah Bettini et al.   Scientific Reports

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome

(2016) Pedro A Ruiz et al.   GUT

Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions

(2016) Héloïse Proquin et al.   MUTAGENESIS

Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the Dutch population

(2016) Cathy Rompelberg et al.   Nanotoxicology

Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations

(2016) Minne B. Heringa et al.   Nanotoxicology

Effects of titanium dioxide nanoparticles on intestinal commensal bacteria

(2016) Li-Ying Liu et al.   Nuclear Science and Techniques

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

(2015) Malin E.V. Johansson et al.   Cell Host & Microbe

Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota

(2015) Alicia A. Taylor et al.   ENVIRONMENTAL ENGINEERING SCIENCE

Impact of anatase and rutile titanium dioxide nanoparticles on uptake carriers and efflux pumps in Caco-2 gut epithelial cells

(2015) M. Dorier et al.   Nanoscale

A review on potential neurotoxicity of titanium dioxide nanoparticles

(2015) Bin Song et al.   Nanoscale Research Letters

A review on potential neurotoxicity of titanium dioxide nanoparticles

(2015) Bin Song et al.   Nanoscale Research Letters

SYRCLE’s risk of bias tool for animal studies

(2014) Carlijn R Hooijmans et al.   BMC Medical Research Methodology

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

Characterization of Food-Grade Titanium Dioxide: The Presence of Nanosized Particles

(2014) Yu Yang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Using physiologically based pharmacokinetic (PBPK) modeling for dietary risk assessment of titanium dioxide (TiO2) nanoparticles

(2014) Gerald Bachler et al.   Nanotoxicology

Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia

(2014) Emilie Brun et al.   Particle and Fibre Toxicology

Engineered Nanomaterials in Food: Implications for Food Safety and Consumer Health

(2014) Alina Martirosyan et al.   International Journal of Environmental Research and Public Health

Correction: Bacteria Regulate Intestinal Epithelial Cell Differentiation Factors Both In Vitro and In Vivo

(2013) Svetlana Becker et al.   PLoS One

Titanium Dioxide Nanoparticles in Food and Personal Care Products

(2012) Alex Weir et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Characterization and Preliminary Toxicity Assay of Nano-Titanium Dioxide Additive in Sugar-Coated Chewing Gum

(2012) Xin-Xin Chen et al.   Small

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice

(2009) Yanmei Duan et al.   BIOMATERIALS

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE